Effect of Cottonseed Extracts on Haematological Parameters of Albino Male Mice

Abstract

The objectives of the present study are to determine the effect of differentconcentrations of aqueous and oil extracts of cottonseed on haematologicalparameters. Groups of male mice were orally administered aqueous extract[20mg/kg/l day (G2) and 40 mg/kg/day (G3)] and other groups were administeredoil extract [20% (G5) and 40% (G6)] for six weeks.The results showed that there was a significant (P<0.05) reduction in Hbvalues for mice treated with 20% and 40% oil extract as compared to the control.Also, significant (P<0.05) reduction in the percentage of PCV were noticed forboth concentrations of extracts as compared to the control groups. While nonsignificant (P>0.05) differences were shown in RBC and WBC count amongG5and G6 as compared to G4. Significant (P<0.05) increment in the plateletcount was shown in G2, G3, G5 and G6 as compared to the control. Differentialleukocyte analysis showed that a significant (P<0.05) reduction was observed inthe percentage of lymphocyte and significantly (P<0.05) increase neutrophils inG2 and G3 as compared with G1 and in G6 as compared to G4. While,monocytes (%) were significantly (P<0.05) decrease in G5 and G6 as comparedto G4. However, 40mg/kg/day aqueous extract dose demonstrated a significant(P<0.05) increment in the percentage of eosinophil and basophile cells ascompared to G1.