Synthesis and Characterization of Some New Spiroazetidine-2- one Derivatives

Abstract

Abstract The present work include the synthesis and characterization of spiro azetidin-2-one which achieved and expected to have some biological activity . the first step include the treatment of primary aromatic amine with primary aromatic aldehydes in boiling ethanol to give schiff bases which reacted in the second step with carboxylic acid ( 1,3-dithia-2-carboxylicacid )in the presence of triethylamine with phosphorusoxychloride in dry dichloromethane under nitrogen atmosphere at 0°C. To give spiroazetidin-2- one.The new synthesized compound were identified by melting points and UV,FT. IR, Mass, 1H NMR and 13C NMR spectrum