Synthesis and Biological study of N-Cysteine Derivatives Via a Schiff Base

Abstract

Abstract This work includes the synthesis of some derivatives of cysteine and the biological activity was investigated. The aromatic Schiff base which prepared from aniline and benzaldehyde was reacted with α-chloroacetic acid and with different acid halide in dry benzene to give benzyl chloride (Compounds : 2, 3, 4, 6) which were reacted with L&D-Cysteine to give N-α-N¯-cystylbenzyl-N-alkanilide. The last synthesized compounds were identified by melting points, UV-Visible, IR and 1H-NMR spectrum. Thy were also tested against E.coli, Staphyllococus aureus, Klebsilla spp., Streptococcus pyogen, Listeria Moncytogen, Sallmonela typhi., Pseudoms aerugenosa and Brucella.