الكشف عن فعالية المستخلص المائي للتمر في الوقاية من الإشعاع في الفئران البيض

Abstract

The present study was undertaken to evaluate the radio protective activity of the date aqueous extract in mouse somatic and germ cells were analyzed cytogenetically by determining the mitotic index and chromosomal aberrations (chromatid break, chromosome break, ring chromosome and dicentric chromosome) as well as micronuclei formations and sperm head abnormalities.The result revealed that doses (0.1,0.5,1.0 and 4.0) Gray of whole body irradiation induced a significant decrease in cellular proliferation activity in somatic and germ cells andincrease in spontaneous frequencies of chromosomal aberrations, micronuclei formation and sperm head abnormalities. Administration of date aqueous extract at doses of (160,320,640) mg/kg for body weight, had been investigated using the above described parameter. The study showed that treatment mice of date aqueous extract by orally for 1 week before and after irradiation exposure. However, date could give lower protection if it was given after irradiation.In conclusion this study may be a fruitful promise to people under radiotherapy as well as to control incidence of radiation over exposure among radiation workers, and people inhabitant in are with radiation pollution.