Systemic effect of tranexamic acid on Prothrombin and clotting times in rabbits after IV injection of heparin (Experimental study)

Abstract

Aim: To evaluate the effect of a single dose of tranexamic acid (cyclokapron) in reducing thepostoperative bleeding following minor oral surgery on ten rabbits on anticoagulant therapy (heparin).Materials and Methods: Samples of blood were collected pre and post heparin and tranexamic acidinjection for measuring the Prothrombin and clotting time. Results: There was no significant differencebetween the Prothrombin time and clotting time normal and Prothrombin time and clotting time aftertranexamic acid injection. Conclusion: A single dose of tranexamic acid given postoperatively waseffective in reducing the postoperative bleeding following minor oral surgery in experimental rabbit onheparin anticoagulant therapy without changing the regular heparin regimen doses. The same regimenmay be applied on hospitalized patient on heparin anticoagulant therapy