Histological and Functional study of white male mice testes and kidney treated with Tecrium Polium aqueous extract


The oral administration of the aqueous extract of Teucrium polium to amature male mice in daily oral doses of 50 mg/kg body weight (group II) and 100mg/kg body weight (group III) for eight consecutive weeks were resulted insignificant increase (P<0.05) in the testicular weight in the treated groups incomparison with control. The aqueous extract affected the spermatogenesis whichdemonstrated by an increase in leydig cell, spermatogonia, spermatocytes andspermatozoa. The hormonal profile was influenced by the aqueous extract. Thetestosterone level was significantly increased (P<0.05) in the treated groups, butno significant differences (P>0.05) in urea and uric acid levels between controland the treated groups were shown. The kidneys of the group III were affected andshowed degenerative changes and necrosis in nucleolus of cell of tubules and thereis destruction in glumerular by increscent of mesenchymal cells.