Treatment of Acne Vulgaris With Nigella Sativa Oil Lotion


ABSTRACT:BACKGROUND:Acne vulgaris is the most common chronic inflammatory disease of the skin. Despite the vast array of treatment modalities available for acne, there is considerable dissatisfaction in acne treatment among patients and doctors. Cost limitation, adverse effect or lack of efficacy limit the use of current therapy. Herbs and their extracts have been used for treatment of skin disease for centuries. One of the most popular herbs in our society is Nigella sativa; this plant had diverse clinically useful activity.OBJECTIVE:To use nigella sativa oil as natural plant remedy in the treatment of acne vulgaris.METHODS:This study was conducted in the Department of Dermatology and Venereology in Baghdad Teaching Hospital, Iraq during the period between October 2005 and April 2006. In this single-blind randomly controlled therapeutic study, ninety three patients were enrolled, their ages ranged from 13-23 years. There were 51` females and 42 males. The patients were divided into 2 groups; group A (47 patient) instructed to use nigella sativa oil lotion twice daily for 2 months, while group (46 patient) used a control solution. Acne vulgaris was graded as mild and moderate acne by counting the number of papules and pustules. Statistical analysis was carried out by computer using t-test, f-test, and chi-square when needed.RESULTS:Eighty-one patients completed the study. In group A (43 patients), we noted a significantly reduced mean lesion count of papules and pustules after 2 months of therapy. The response of patients to treatment was good in 58%, moderate in 35% and no response in 7%. The satisfaction of patients with treatment was full in 67%, partial in 28%, and no satisfaction in 5%. In group B (38 patients), the lesions showed no significant reduction after 2 months and the response of patients to treatment was good in 8%, moderate in 34%, and no response in 58%. The satisfaction of patients with treatment in this group was full in 8%, partial in 24%, and no satisfaction in 68%. The mean difference in outcome after 8 weeks between the 2 study groups was statistically significant.CONCLUSION:The nigella sativa oil lotion has proved its efficacy as a topical therapy for acne vulgaris. This is a new natural plant extract, which lacks any side effects