Anti-Tumor And Immuno-modulating Effect of Honey in Normal And Tumor-bearing Mice


In our previous study, it has been reported that honey have anti-proliferative and apoptotic effects against Hep-2 and AMN-3 tumor cell lines in vitro. The present study was designed to investigate that the effect of intraperitoneal administration of honey against tumor growth in murine mammary gland adenocarcinoma-implanted mice, the volume and weight of tumor, mitotic index of bone marrow stem cells as well as serum IL-2 and IFN-Ύ were assessed. The results showed significant tumor growth inhibition in honey-treated mice by reducing tumor volume and tumor weight about 78.5% and 43.6% respectively.Moreover, mitotic index was significantly increased (p<0.01) in honey-treated groups of both normal (10.3 ± 0.85) and tumor-bearing mice (14.4 ± 0.8) in comparison to their controls (10.8 ± 0.8 and 7.4 ± 0.53) respectively. However, the honey treatment caused significant elevation (p<0.01) in the level of IFN-Ύ only but not for IL-2 in the sera of tumor-bearing mice. These results indicated that honey has anti-tumor effect either through its direct activity against tumor mass or indirectly through enhancing the immune system.