Evaluation Of The Psychopharmacological Effects Of Loratadine With Concomitant Adminstration Of Erythromycin

Abstract

AbstractIn this study, the effect of a single oral dose (10 mg) of a 2nd generation antihistaminic agent – loratadine - administered alone or with a metabolic inhibitor – erythromycin - on psychomotor performance was investigated on 6 healthy volunteers.Recording of movement reaction time and assessment of subjective feeling of sedation was done before medication and hourly afterward for 3 hours.The results were analyzed statically by using “student’s t test” which showed that loratadine erythromycin combination induced a statically significant impairment of psychomotor performance demonstrated by prolongation of finger tip reaction time.