Prognostic significance of specific proteins and immunoglobulins in sero positive Rheumatoid Arthritis patients

Abstract

Background: Increased levels of specific proteins and Immunoglobulines have been detected in serum from patient with rheumatoid arthritis (RA).Objective: To clarify the clinical significance of specific serum proteins and Immunoglobulin in RA. Methods: Forty- two patients with sero-positive rheumatoid factor (group 1 and 2 according to disease activity progresses) and twenty age- matched healthy subjects were included in the study. Serum total proteins, Protein electrophoresis and Immunoglobulin level were evaluated. Results: Acute phase reactants in RA patients showed a significant increase in comparison to healthy subjects (P < 0.001). There was a significant difference in the levels of α- globulins, γ-Nglobulins, IgG and IgM in group 1 as compared to group 2.Conclusion: The prognostic value of serum specific proteins and Immunoglobulin in patients with RA is high, and can provide some help in predicting the outcome of joint inflammation.