The effect of fluoride on osteoblast cell population after in vivo administration

Abstract

Background: The osteoblast is characterized by its ability to synthesize a welldefined mineralized collagenous matrix, regulate the remodeling process bysynthesizing local hormone, specific molecules and alkaline phosphataseenzyme .The aim of this study was to evaluate the effect of Sodium Fluorideadministration in vivo on osteoblast cell.Materials and methods: Fourteen pregnant Sprague- Dawley rats were used, 8 ofthem received 100ppm Fluoride, others did not received and considered ascontrols. Bone biopsies from neonatal rat were studied histologically andhistochemically.Results: Active proliferation of osteoblast and their progenitor cells with activelocalization of alkaline phosphatase in neonatal jaw bone treated with SodiumFluoride.Conclusion: under the condition of the present study, the Sodium Fluoride can beused successfully to enhance bone formation.