Estimation of Serum Anti-Cyclic CitrullinatedPeptide, Glutathione, Copper and Zinc in Patients with Multiple Sclerosis


This study aimed to determine the level of anti-cyclic citrullinated peptide(ACCP), glutathione (GSH), copper (Cu) and zinc (Zn) in sera of the patients withMultiple Sclerosis (MS) and healthy subjects to examine their possible role in thisdisease. Thirty patients in MS were included for evaluation of serum anti-cycliccitrullinated peptide (ACCP), glutathione (GSH), copper (Cu) and zinc (Zn) andthey compared with thirty normal healthy subjects. Results revealed that the serumlevels of GSH and Cu were highly significant lower in MS patients than in healthycontrol group p< 0.005. The mean serum levels of Zn for both groups weresignificantly decrease p< 0.04, but the mean serum levels of ACCP in both groupswere no significantly decrease p > 0.201.