Effects of Phenolic Compound on the Viability of Leishmania tropica promastigotes: A comparative in vitro study

Abstract

This in vitro study aimed to evaluate the effectiveness of Caffeic acid against the viability of Leishmania tropica promastigotes in vitro. The result showed that Caffeic acid had a fatal effect on the viability of Leishmania tropica promastigotes with the use of different concentrations leading to a gradual decreasing of living promastigotes number with the increase of Caffeic acid concentration. The mean parasiticidal effect of Caffeic acid was (24×104, 30×104, 38×104, 44×104, 53×104) promastigote /ml at concentrations (10, 15, 20, 25, 30) mg/ml respectively after three days of incubation. It can be concluded that Caffeic acid posses a cidal effect on the Leishmania tropica promastigotes in vitro." P < 0.01 ".