Desmopressin Acetate Effects on Human Vigilance Task and Psychomotor Performances in Normal Healthy Volunteers: Randomized Single Blind Clinical Trail

Abstract

AbstractBackground: Desmopressin is a synthetic form of human vasopressin hormone act chiefly on V2 receptor that found in vascular and brain tissues ;and it's primarily used for treatment of nocturnal enuresis .Also previous studies in animals suggested that central vasopressinergic system proceed on cognitive function .Aim of study: This study aimed to estimate the central effects of desmopressin on human vigilance task and psychomotor performances in normal healthy volunteers.Subjects and method : This study done in the course of measurement of recognition reaction time (RRT); movement reaction time (MRT),total reaction time(TRT) and flickering-fusion frequency threshold which reflects the vigilance task and psychomotor performances by specific Leeds Battery Instrument before and after single trans-nasal desmopressin acetate in 20 healthy volunteers(17 males+3 females).Results: This study showed that desmopressin produced significant effects on all vigilance- psychomotor performance parameters (P<0.05) with the exception of on critical flickering which produced insignificant effects ( P >0.05).Conclusion: Desmopressin acetate significantly improves human vigilance- psychomotor performances and improves cognitive function so we recommend using this drug for nootropic effects and stimulation of mental function.