Cholesterol Homeostasis and Neurological Complication in sera of patients with chronic renal failure

Abstract

Varieties of complications have been recognized in patients with chronic renal failure, such as neurological complications. This articles aims to study a neurological complication in patients with end stage renal disease (ESRD) through determine of the MAO activity, Na+, and K+ and the role for cholesterol in neuron function/degeneration through its correlation to MAO activity. Twenty three patients with ESRD were studied and compared to twenty healthy individuals. Significant increase of MAO activity (p<0.05) and cholesterol (p<0.001) were observed in the sera of patients with ESRD compared to the control group. While a non significant increase of sodium and potassium (p>0.05) were found in the present study in the sera of patients with ESRD compared to the control group. Also a non significant correlation (p>0.05, r=0.21) were found between MAO activity and cholesterol. Keywords:- renal failure, monoamine oxidase, cholesterol, neurologic ,complication.