Synthesis and Characterization of (Oxazepine,Diazepine,Tetrazole) for Derivatives of Sulfamethoxazole Drug

Abstract

The present work involved synthesis of serval new substituted (Oxazepine,Diazepine and tetrazole via Schiff bases for selfamethoxazole drug by four steps. The first step involved preparation Schiff bases (A1-A5) by condensation of selfamethoxazole drug with many substituted ketones,then ,the second step include ,preparation new five oxazepines compounds (B1-B5) by reaction of phthalic anhydrid with the prepared Schiff bases in first step . The third step including reacting compounds (B1-B5) which prepared in the second step with primary oramatic amines to give new five Diazepine compounds (C1-C5) . Finally the fourth step, preparation new tetrazole derivatives D1-D5 by reaction of the prepared Schiff bases (in the first step) with sodium azide in THF. The prepared compounds were characterized by physical properties ,(FT-IR,UV. and some of them by 1H-NMR , 13C-NMR spectroscopy) were recorded and the biological activity was evaluated against two kinds of bacteria gram positive and gram negative.