LEPTIN EFFECTS ON , THYROID HORMONES AND SOME BIOCHEMICAL PARAMETERS OF FEMALE RABBITS (LEPUS CUNICULUS) SERUM.

Abstract

Thirty local female rabbits were divided randomly and equally into three groups. The 1stgroup used as control which injected with phosphate buffer salin. The 2nd group was injecteddaily with leptin (5μg/animal) S/c. The 3rd group was injected subcutaneously daily with(10μg/animal) S/c. All groups were treated for 60 days, and blood samples were collected every15 days, serum was tested for T3, T4 hormones, total Cholesterol (TC), HDL (height densitylipo-protein) , LDL (low density lipo- protein), TG (triglycerides) and Body weight was takenevery 15 days during the experiment .The result show significant (P≤0.05) decreased in body weight after administration ofleptin in two doses. Significant increased in Thyroid hormone after leptin administration. Whilelipid profile (TC, TG, LDL, HDL,VLDL) show significant decreased with leptin treatment(5 and10μg/animal) S/c.