Synthesis, Structural Study, Antimicrobial Activity and Theoretical Treatment of 3d-metal Complexes Involving Schiff Base of Piperonal Derivative

Abstract

Abstract:New VO (II), Cr (II), Co (II), Ni (II), Cu (II) and Zn (II) Schiff base complexesderived from piperonal have been synthesized and characterized by spectroscopic methods,conductivity, metal analyses and magnetic moment measurements.The nature of the complexes formed in ethanolic solution was study following themolar ratio method. From the spectral studies, Octahedral geometry was suggested for allprepared complexes except Vanadium (IV) and zinc (II) complexes have square pyramidaland tetrahedral geometry respectively, Structural geometries of these compounds were alsosuggested in gas phase by using hyper chem-8 program for the molecular mechanics andsemi-empirical calculations.The heat of formation and binding energy for the prepared compounds was calculatedby using PM3 and ZINDO/1 methods. The method of PM3 was used for evaluate thevibration spectra for the imine and starting material as authentic compound.Preliminary in vitro tests for antibacterial and antifungal activity show that most ofthe prepared compounds display good activity to (Staphylococcus aureus), (Escherichia coli)and (Candida albicans)Keywords: Schiff base, Piperonal, hyper chem-8, in vitro, Activity.