تأثير مضاد الأندروجين الفلوتامايد على نسيج ووظيفة الكبد في ذكور الجرذان البيض

Abstract

This study conducted to evaluate the effects of antiandrogen flutamide drug in physiological and histological liver in white male rats that treated with flutamide ,this study included 20 male rate divided into 5 groups ,3 treatment groups treated with flutamide 8,12,25 mg/kg/day, and control group divided into two groups ,negative(corn oil) and positive (distal water) control , all animals treated for 28 days, the result showed a significant effects (p<0.05) on liver weight ,histology and enzymes of liver ,since liver weight increased significantly in treated group 12 mg/kg/day in a comparism with negative control only , but all groups did not effect significantly in liver weight compared with negative and positive group.The GOT enzyme showed significantly increased at concentrations 8,12 mg/kg/day when compared with negative control , while this enzyme decreased at concentration 25mg/kg/day compared with negative control , in addition to decrease of GOT of concentration 25 mg /kg/ day when compared with the treatment 8,12 mg/kg/day . while significantly decreased of GPT enzyme level of group treatment of 8 mg/kg/day when compared with positive control and insignificantly decrease of 12,25 mg/kg/day concentration compared with positive control and don’t arrived to significantly with negative control .Histological study of liver tissue showed structural defects of liver tissue represented by presence of inflammatory cells , vacuoles inside of liver cells , increase of abnormal number, of kuppfer cell , stock infiltration of liver cell and necrosis of liver cells.