Oxidant and Antioxidant Activities of Copper and Selenium in Leukaemic Patients

Abstract

Two trace elements (copper and selenium) were evaluated in the present study during four types of leukaemia :(acute lymphocytic and myelocytic leukaemia (ALL,and AML))and( chronic lymphocytic and myelocytic leukaemia(CLL and CML)) which compared with normal values of healthy subjects . The study also attempted to shed a light on possible relation between the mentioned elements and lipid peroxidation marker (malondialdehyde (MDA)). An elevation in serum copper was observed during all studied types of leukaemia , with positive correlation between copper and MDA levels . Also correlation between serum copper and albumin levels could be obtained .Selenium level was found to be decreased during all types of leukaemia with negative correlation between its levels and serum MDA .