Table of content

Tikret Journal of Pharmaceutical Sciences

مجلة تكريت للعلوم الصيدلانية

ISSN: 18172716
Publisher: Tikrit University
Faculty: Pharmacy
Language: English

This journal is Open Access

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Table of content: 2006 volume:2 issue:1

Article
Evaluation of The Effects ofAmlodipine Therapy on Blood Pressure and KidneyFunction among Hypertensive Patients in Mosul City.

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Abstract

The present snrdy was mnducted to evaluate fte effect of amlodipine on blmd p€ssurc and kidney function in
patients in Mosul clb,. Thirty patients participated in ftis S.rdy ( 14 female ard 16 nrale )
Arnlodipine was administercd for a period of 8 weeks in doses of 5 to l0 mg once daily. Antlripentensive efficacy was
assesd by measurement of blood pressure by standand mercury sphygmomanometer before and afur rcdnent . Blood
sampleswercobtained fiomeachpatientbeforeardafurteatnentand tlreobtainedserawereanalpodforruralpaarnetas
vririch they all measr"ned in serum by using mlorimetic and en4anaic mehod. Credinine cleararce was calculded bywing
the Cockoft and Gault ecluation.
The resulb of the study showd that anlodipine drerqpy lead tl a sigrificant reduction in blood pressue tllrugfrout the
study and about 5fflo ofthe patien8 exhibit BP reduction tc notmal values afur drerapy. CreAinine clearance was significarfly
increased afur the end of the sudy . All other renal parameten including urea , credinine, sodilnn and potassium
concentdions showed a sigrificant reductions. It was concluded that therapy with arnlodipine car be useful ard effedive
flrcmpyinhpefiensivepaientswith deterioratdkidneysfi.lictionin oncedailydosage.

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Article
Study of the antibacterial activity of Malva Neglegta
دراسة الفعالية المضادة للبكتريا لخلاصة نبات الخباز

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Abstract

Different extract of Malva neglecta were investigated for their antibacterial
against Streptococcus pneumonia, Staphylococcus. aureus. Haemophilus. Influenza.
Moraxella,. catatahhs. Almost all extract produced significants antibacterial activity
against all microorganisim the in comparisom with Gentamicin
sulphate.Petrolium.ether was more effective than the other extract
. The flavonoids was separated on silica gel thin layer chromatography and
responsible for this activity the study determined that t antibacterial action is related
to flavonoid.

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Article
Evaluation of serum lipid in diabetic patients on differenttypes of treatment
تقييم نسبة الدهون الدم لمرضى داء السكري المعالجين بمختلف انواع العلاجات

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Abstract

Diabetes mellitus is chronic metabolic disorder which causes many complications. These are subdivided into
microvascular complication affecting retina, kidney and peripheral nerves and macrovascular complications
(atherosclerosis) affecting the major arterial systems including coronary arteries. Abnormal lipid metabolism is
common in DM and it play an important role in the macrovascular complications. In this case control study
150 diabetic patients on different regimens of treatment were investigated for hyperlipidemia and compared to
each other and to 50 apparently healthy control.
Comparison of each group of diabetic patients with the control group was as follow; regarding total cholesterol
there was no significant difference, higlyceride was significantly higher in group 2 (mixed insulin and oral
hypoglycemic therapy), and group 3 (oral hypoglycemic drugs therapy) (P<0.001) in comparison with control
group, while in group I (only insulin therapy) it was lower than the control group, but the difference was
siatistically not significant, HDL was significantly lower in all groups in comparison with control group and the
least value of HDL was found in group 3 (P<0.001). Regarding LDL there was no significant difference in
comparison with the control group, while VLDL was higher in group 2 and 3 than the control group and the
difference was significant (P<0.001). Comparison of the measured parameters among three groups of diabetic
patients was as follow; regarding total cholesterol and LDL there was no significant difference among these three
groups. Triglycerides and VLDL were significantly lower in group 1 (P<0.001), while HDL was significantly
lower in group 3 (P< 0.001). Cholesterol, triglycerides and VLDL were significantly higher in females in group 2
(P<0.05). Regarding HDL and LDL no significant difference was found between males and females. In group I
triglyceride was higher in those with 5 - l0 years treatment, while in group 2 & 3 there was no significant
difference in measured parameters regarding the duration of treatment.

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Article
STUDY OF THERAPEUTIC EFFECT OF BLACK SEED OILON HYPERLIPOPROTENIMA
دراسة تأثير زيت الحبة السوداء على فرط الدهون

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Abstract

Hyperlipoproteiteinemia is well established as a major risk factor for cardiovascular
diseases . Lowering of serum liquids were found to be associated with the reduction in
cardiovascular diseases .The aim of this study is to determine the effect of Nigella sativa
oil on the serum lipids , Fasting blood glucose and uric acid in Hyperlipoproteinemia
patients. Blood samples were taken from (30) patients suffer from Hyperlipoproteinemia
and volunteered to take Nigella sativa oil .The blood samples from these groups were
analyzed for measuring serum total choesterol triglycerides , phospholipids ,low density
lipoprotein,fasting blood glucose and uric acid before and after taking Nigella sativa oil
.The results revealed that Nigella sativa oil was shown to decrease significantly the levels
of total cholesterol , triglycerides, phospholipids , LDL cholesterol and uric acid while
there were no effects on VLDL -cholesterol and fasting blood glucose , it was also shown
significant increase in the levels of HDL- cholesterol

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Article
The effect of date palm pollen & zinc sulphate in thetreatment of human male infertility.
تأثير حبوب طلع النخيل وسلفات الزنك في عقم الذكور

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Abstract

This study was performed to determine the possible synergistic effects between zinc
sulphate & pollen of Date palm in the treatment of men infertility. Pollen powder was
packed as 500 mg iq capsules,. while zinc sulphate capsule was prepared by packing
100 mg of zinc sulphate with 400 mg glucose in gelatinous capsule. A combined
therapy used for treatment of 25 infertile men as one capsule for each patient twice
daily for 3 months. The treatment was significantly increased serum LH, FSH, &
testosterone levels. It was also, increased significantly sperm count & motility. Sexual
desire was also significantly increased. Wives of treated men got pregnancy during
the treatment period. Combined therapy of Date palm pollen & zinc sulphate cause no
biochemical & hematological toxicities.

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Article
Correlation between diabetes mellitus and hyperlipidemia inpatients with ischemic heart disease
العلاقة بين مرض السكري وفرط الدهون لدى مرضى احتشاء عضلة القلب

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Abstract

Diabetic is commonly associated with abnormalities in plasma lipids and lipoproteins levels
'In particulars, diabetes mellitus, usually presents with concomitant elevations ln the plasma
triglycerides levels and reductions in plasma HDl-cholesterol concentration. These
abnormalities certainly play a role in the increased risk for cardiovascular disease, particularly
ischemic heart disease (IHD). Blood samples were taken from (150) healthy control zubjects (86
male and 64 females), (150) patients suffer from previous signs of IHb (84 males and 66
females) were involved in this study. The blood samples from ihese groups were analy zed, for
measuring serum total cholesterol, triglycerides, phospholipids, low-density lipoprotein, very
low density lipoprotein, high- density lipoprotein and fastingblood glucose .All controt suUiects
have a normal fasting blood glucose, normal resting electrocardiograph, blood pressure and
serum lipids. Diabetics have been shown to have high levels of serum lipids than non diabetics
and it also important role in the occunence of IHD particularly in hyperlipidemic patients.

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Article
The Antibacterial Activity of Aqueous Extracts of Coriander &Mustard.on Some Bacterial Isolates
التأثير البكتيري المضاد للمستخلصات المائية للكزبرة والخردل على بعض العزلات البكتيرية

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Abstract

This study was designed to investigate the activity of herbal decoctions on different bacterial
isolates. The antibacterial activity of herbal extracts was evaluated against Staphylococcus aurelts,
Streptococcus pneumoniae, E. coli, Klebsiella pneumoniae and Pseudomonas aeruginosa.
Decoctions of Coriandet (Corianeilum Sativum) & Mustard (Brassica Nigra) were prepared
according to traditional herbal recipes. Simple disk - diffusion method was employed over all the
decoctions exhibited a positive effect on the bacteria by decreasing and inhibiting the bacterial
growth.

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Article
combined cutaneous and Visceral Forms of Leishmaniasisl
اجتماع ليشمانيا الجلد وليشمانيا الاحشاء معا

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Abstract

This is a three years old child from Himreen rural areas the patient had fever,
pallor, & hepatosplenomegaly and two ulcers on the face. The patient responded to
Pentostam. While we used in Iraq to see leishmaniasis as either pure cutaneous or
pure visceral forms of leishmaniasis, this is a case with combined cutaneous &
visceral forms of leishmaniasis in a patient with normal immune system. Which may
explained by the leishmaniae species that primarily cause cutaneous disease & rurely
cause visceral disease,or by primarily viscerotropic leishmahia that primarily cause
visceral disease which may also cause skin lesions or by mixed infections by two
different species of leishmaniae, one of them is dermatotropic, & the other one is
viscerotropic.

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Article
Distribution Of Dental Caries Among Primary School ChildrenIn Al-Mukalla Area - Yemen
توزيع حالات تسوس الاسنان ضمن طلاب المدارس الابتدائية في منطقة المكلا- اليمن

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Abstract

This cross-sectional study is canied out to identify the distribution of dental caries among
400 primary school children of 12 years age in Al-Mukalla area in Yemen.It was found
that 198 (495%) out of 400 school children have dental caries; of those affected children
5L5% were males, and 48.5% were females. Dental caries was found to occur more in
permanent teeth (76.6%) and distributed mostly in the lower jaw (54%). It is more
distributed in urban areas where the affected seen to represent 53o/o, whereas in the rural
areas it was 38%. In comparison, the distribution of dental caries (among the affected) in
private schools (57o/o) is more than that in governmental schools (47%), and the children
living in areas receive their water supply from Al-Ghail, Source 1, are affected (53.6%)
more than those living in areas supplied from Al-Taweela, Source 2, (42.7%). Finally
dental caries causes missing of the teeth in 8% of children

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Article
Prevalance of self - medication( self - Drug use)in Hadhramout Governorate

Authors: Ahmed Ali Bahaj احمد علي
Pages: 64-70
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Abstract

Self-medication is worldwide method of prevention and treatment of many health problems and
self -use of drugs is commonly practiced. To evaluate the prevalence of this problem in our
community in Hadhramout this study was conducted.Data were collected from randomly
selected dispensaries and drug stores in the four largest cities in Hadhramout, Mukalla,Al-shiher
,,Al-ghail &Sayoon during the period October - December 1999 .1100 out of 4040 (27% ) were
self-drug users .(39%) were 21-30years age ,(22%) over 40 years and (I4%) bellow
l0years.(67%") of self- drug user were of primary school level of education and bellow, (17%o)of
secondary school and (16%o) of university level. The most common methods of drug requisition
were to desuibe the complaints to the dispenser (35.8%o), (21.4%o) showed sample of drug or
empty container and some brought an old prescription (11.5%o). some other methods of
requisition were also seen. Analgesics-antipyretics were the most drugs requested (35.7%o),
antibiotics (25.9%o), drugs for respiratory system (10.4%o), ant parasitic (5.2%") and antacids
(5%Q. Tonics and drugs for DM, HTN were also requested by this methods. The most common
cause of self- medication were previous experience (48.3%o), advises from relatives andfriends
(10.3%o) and thinking of simplicity of the diseases that no need to consult a doctor (10.3%o).
(60%0) of the patients lrnow some adverse reaction of the drugs, (25%o) knew and (15%r) didn't
know about .Of all the patients (42.8%0) practicing self-medication occasionally, (31%o) very
rarely and (26.2%o) mostfor the timeslt is concluded that self-drug use is commonly practiced in
our community as affirdable and easy way of treatment by dffirent age groups and at all levels
of education. There is misuse and iirational over use of not only the OTC drugs but almost every
Qpe of drugs. Suitable health education programs, Proper regulations and close observation is
recommended.

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Article
Prevalence of and risk factors of anemia among pregnantwomenMukalla - Hadhramout - Yemen

Authors: Ahmed Ali Bahaj --- Ahlam Saleh Bin briek
Pages: 71-77
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Abstract

Anemia is among the public health problem especially in developing countries. Yemen is
not an exceptional.Methodologlt'this study is cross sectional study, which is conducted
during the first 6 month of the year 2004 and involved 300 pregnant women attending 4
main MCH centers in Al-salam, October and Fowa regions. The data were collected used
a questionnaire. The blood samples were extracted by finger prick.Resufts.' Showed that
anemia is a common feature among blood pregnant women (819/0) in comparison to
(I9%) that are not anemic.Conclusion and recommendations.' Prevalence of anemia
among studied pregnant women were frequent in all age groups and anemia is less in the
first trimester (5.3%).Increasing level of awareness in women and their families about the
risk of anemid in pregnancy and to create the need for iron supplement.

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Table of content: volume:2 issue:1