Table of content

Al-Mustansiriyah Journal for Pharmaceutical Sciences

مجلة المستنصرية للعلوم الصيدلانية

ISSN: 18150993
Publisher: Al-Mustansyriah University
Faculty: Pharmacy
Language: English

This journal is Open Access

About

Al-Mustansiriah Journal of Pharmaceutical Sciences (AJPS) publishes original articles in Pharmaceutical, Medical & related sciences including:
Research articles in Pharmacology, Toxicology, Clinical Pharmacy, Medicinal Chemistry, Pharmaceutics, Clinical Laboratory Sciences, and Pharmacognosy. AJPS published twice yearly.

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Contact info

For more information visit (AJPS) website
http://mjops.com/
E-mail: collegeofpharmacy@uomustansiriyah.edu.iq
P.O. Box: 14070
E-mail: mjops@uomustansiriyah.edu.iq
G-mail: journalcolpharm@gmail.com

Table of content: 2005 volume:2 issue:1

Article
Occurrence of HSV with other microorganisms in female genital infection

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Abstract

Genital herpes is one of the most common sexually transmitted diseases. Ulcerations of primary genital herpes may be susceptible to secondary infection with bacteria, fungus or even viruses. This study was directed to investigate the incidence of HSV and other pathogens in female patients presented with vaginal discharge and/or genital discomfort. Special attention was directed toward the possible occurrence of HSV with other pathogens in the same individual. Two vaginal swabs were collected from 80 female patients, and from 20 healthy women which were represented as age match control group. One swab was tested with commercial enhanced enzyme immunoassay for the direct detection of HSV 1 & 2 antigen. The other swab was used for formal bacteriological and mycological culture, and for microscopy. HSV antigen was detected from the genital area in 21 of 80 patients (26.25%), and in 4 of 20 control group (20%). The diagnosis of candida spp. Trichomonus vaginalis , and Neisseria gonorrhoeae was established in 15%, 8.75%, and 2.5% of the patients respectively. Other microorganisms were also diagnosed in some patients. Of the 21 patients proved to be infected with HSV, combined coexistence with other pathogens was proved to be in 11 patients (52.4%), with a highest percentage (28.6%) was found with candida spp. Followed by combined HSV with different species of bacteria (14.3%), also this coexistence was found in 9.5% (2), and 4.8% (1) of patients infected with T.vaginalis and N.gonorrhoeae respectively. One HSV infected patient (4.8%) was found to be infected with both T.vaginalis and Staph. aureus. While this concomitance infection was found in only one (25%) of the 4 normal females proved to be infected with T. vaginalis beside HSV. From the results of this study we can conclude that herpes genitalis is a common genital tract infection among Iraqi females. Furthermore, genital herpes often occur in association with one or more other pathogens.

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Article
Topical preparations from the Iraqi plant aloe vera and their efficacy in skin infections.

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Abstract

The dermatological preparations consist of simple or compounded bases in which one or more active ingredients are dissolved or suspended .The plant Aloe vera is widely distributed in Iraq, in addition to it's tranditional use in the treatment of occasional constipation , it is also used to assist healing of wounds ,burns and psoriasis. In this study; the amount of aloin (the major component of the plant) in the dried juice of the Iraqi plant Aloe vera is determined and was found to be 15.4% w/w and it is the major compound responsible for the antimicrobial activity of the plant. Different ointment bases were used in this study to prepare topical preparations from the dried juice of the Iraqi plant with different concentrations and were found that 4%w/w sodium carboxy methyl cellulose gel base was the best formula using comparative diffusion study through the skin. The clinical study which is carried out in this research on 61 patients with skin infections (mainly Tinea corporis and Tinea cruris) showed that 4%w/w gel base formula of aloe gave significant improvement in comparison with those treated with nystatin and hydrocortison and proved the antipruritic and antiinflammatory action of the dried juice of the Iraqi plant Aloe vera without any adverse effect. Finally the expiration date of aloin in the selected formula is determined and was found to be ≈ 2 years.

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Article
Effect of new synthesized piperazine derivative containing 1, 2, 4 –triazole ring on the growth of some pathogenic microorganisms

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Abstract

This work describes the antimicrobial activity of newly synthesized 4-methyl (3-mercapto -4- phenyl -4H- 1,2,4-Triazole –5-yl) methyl piperazine. [1]. The newly synthesized piperazine derivative was obtained from basic cyclization of the intermediate product obtained from the reaction between acetic hydrizide –4-methyl piperazine and phenylisothiosyanate(1) .

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Article
Atopy as a risk factor for dermatophytoses

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Abstract

Antagonism between cell-mediated immunity and humoral immunity that develops in atopic patients may be correlated with susceptibility of those patients to dermatophytoses. One hundred and one patients were included in this study from September 2002 to September 2003 to discover the association between atopy and dermatophytoses. The atopic status of patients did not act as a predisposing factor for different types of dermatophytoses, but it increased the susceptibility of such infections to become chronic rather than acute.

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Article
Effect of giardia on some biochemical variables in human blood serum

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Abstract

The alteration in serum glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), alkaline phosphotase (ALP) and total protein during giardiasis were studied. This study has been performed on 53 patients with giardiasis; the control consists of 22 children without giardiasis. The results of each group of patients were compared with the same age of the control, the results indicated that the level of serum GOT, GPT and ALP was significantly higher than that of control for each age , while the level of protein was significantly lower than that for control for each age group. The results indicate that the giardiasis affected the function of liver and the intestine, which lead to some biochemical changes in serum.

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Article
Introduction of polyvinyl pyrrolidone (PVP) In the non surgical periotherapy of Rapidly progressive periodontitis

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Abstract

The non surgical periotherepy are based on the bacteriologic back ground of periodontal diseases. More than 46 different verulant species were composing the bacterial flora. Tetracycline, doxycyline, minocyline were used systemically and / or topically in association with conventional scaling and root planning, as well chlorhexidine and wide variety of antiseptics were used. Rapidly progressive type A and type B being a complex disease showing a specific entity and a complex bacterial flora, a curative non surgical remedy not yet well realized. The polyvinyl pyrrolidone (PVP) a highly effective wide broad spectrum bactericidal, fungicidal and virocidal antiseptic used in low concentration (3%) as an intrapocket irrigation solution accompanied with conventional ultrasound scaling and root planning. Eight patients having rapidly progressive periodontal (3 of type A , 5 of type B) were involved in this study, 12 therapeutic sessions were performed during 6 months. Once a week, in the first month, twice a month in the next 3 months, then once a month in the later 2 months. The result showed a significant improvement of the clinical parameters, gingival bleeding index (GBI), clinical pocket depth (CDD) and clinical tooth mobility (CTM) and with radiologic evidences of bone formation. The result suggests that PVP could be the promising effective, safe, clinically applicable, easy to use, and cheap remedy of complex periodontal diseases.

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Article
Anti-microbial investigation of Suaeda baccata (chenopodiaceae)

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Abstract

This study includes the detection of the anti microbial activity of both the plant extract of Suaeda baccata (Chenopodiaceae) and its constituent the trigonelline alkaloid, against several microorganisms (Staphylococcus aureus to represent one member of Gram positive bacteria, Escherichia coli to represent one member of Gram negative bacteria and Candida albicans to represent one member of fungi) in that trigonelline alkaloid and the plant extract, showed an antibacterial activity against the growth of gram positive bacteria, Staphylococcus aureus, while gram negative bacteria, Escherichia coli and the yeast, Candida albicans were resistant to both.

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Article
Synthesis of nitrocoumarin derivative and separation of its isomers

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Abstract

Coumarins antgonise the effects of vitamine K During the formation of clotting factors II, VII, IX and X in the liver, vitamine K is converted into a biologically inactive metabolite which then reduced back to the active vitamine by the enzyme epoxide reductase. Coumarins which are structurally similar to vitamine K, are believed to act as competitive inhibitors of this enzyme and thus limit the availability of the active form of the vitamine to form clotting factors. Coumarins, e.g. (warfarin) is indicated in deep–vein thrombosis and in pulmonary embolism …etc. The aim of this study is to synthesize and isolate a nitrocoumarin derivative with a possible high intrinsic activity. The nitrocoumarin derivative was synthesized by the reaction of 7–hydroxy, 4–methylcoumarin with mixture of concentrated sulfuric acid and concentrated nitric acid at 0°C. The identity of the prepared compound had been confirmed using UV–Vissibile spectroscopy, I.R spectroscopy, elementary analysis, (sodium fusion test) and HPLC.

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Article
Evaluation of oxidative stress indicators in lymphocytes of patients wih alopecia areata

Authors: al-gaff a.n --- Humadi S. --- Wohaieb S.A. --- Muhi eldeen A.R.
Pages: 63-69
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Abstract

Alopecia areata is a nonscarring hair-loss confition that often has a patchy distribution and can be quite unpredictable

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Article
The topical application of clofibrate in the treatment of acne vulgaris

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Abstract

Acne vulgaris is a common skin disease. The therapeutic approach to this disease includes standard topical and systemic agents to newly introduced alternative medications. This study suggests a new indication for clofibrate (the lipid lowering agent) & that is to be used topically in the treatment of acne vulgaris. The proposed mechanism is by decreasing lipid biosynthesis which takes place in the sebaceous gland. A total of 60 patients with visible papules and pustules of severe acne were enrolled in this study . Their age range between 13 – 31 years (24 males & 36 females). Healthy age matched controls (30 subjects) without any skin diseases were also participated is this study. Clinical investigations involved disappearance of signs and symptoms of the disease while the biochemical investigations involved measuring total cholesterol, HDL, LDL, & TG levels, SGOT, SGPT in the sera of all volunteers done before and 10 days after the topical application of clofibrate (500mg once daily). The effectiveness of the topical application of clofibrate was approved in the treatment of acne vulgaris as a new clinical application of this drug and a novel strategy for the treatment of the disease as there was significant improvement 75% of the patients & moderate improvement for the rest of the patients . In comparison with controls, patients with acne had higher total serum cholesterol and LDL levels with no significant difference in TG, HDL & enzyme levels.

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Article
Changes in serum levels of Total protein , Albumin and Globulin in patients with Behcet's Disease.

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Abstract

ABSTRACT In order to have an idea about some of biochemical changes which might play a role in the pathogenesis of Behcet's disease. Estimation of serum total protein, albumin, globulin and HLA typing were carried out in 70 patients with Behcets disease using colorematric, mathematic & microlymphocytotoxicity tests respectively, compared with 35 patients with recurrent oral ulcers, and 35 healthy control group. Hyperproteinemia, hyperglobulinemia with hypoalbuminemia were observed in those patients in comparison to control groups

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Article
Statistical Treatments and Comparison between Normal Calibration and Ultimate Precision Methods in Spectrophotometric Determination of Aspirin in APC Tablets

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Abstract

In this work a statistical comparison were carried out between two techniques, normal calibration (NC) and ultimate precision (UP) technique, for the spectrophotometric determination of Aspirin (acetyl salicylic acid) in APC tablets, where the second method provide a means of expanding the scale of readout limited instrument and decreasing error significantly. It was found that the relative error was decreased from 6% to 2% on using the UP technique with RSD of 0.86% and 0.54% for NC and UP technique, respectively, Where these data were calculated for synthetic sample with known concentration. The 95 % confidence limit was also calculated for NC and UP methods. An equation was also derived for direct calculation of concentration of unknown from UP technique. Where this equation could be applied for most spectrophotometric determination of sample by UP procedure.

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