Table of content

Medical Journal of Babylon

مجلة بابل الطبية

ISSN: 1812156X 23126760
Publisher: Babylon University
Faculty: Medicine
Language: English

This journal is Open Access

About

Medical Journal of Babylon (MJB) is a quarterly medical journal concerned with clinical and basic medical researches. MJB follows the Publication Ethics Statements suggested by Committee on Publication Ethics (COPE) and International Committee of Medical Journal Editors (ICMJE).

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العنوان البريدي: العراق-محافظة بابل- الحلة –ص ب 473 جامعة بابل –كلية الطب – مجلة بابل الطبية
عنوان البريد الالكتروني medjbabylon2004@gmail.com

Table of content: 2005 volume:2 issue:1

Article
Tumor suppressor gene( E-cadherin )and its role in normal and Malignant cells (Part Two)

Authors: Ali Hassan AL-Timimi
Pages: VIII-XII
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Abstract

Progressive accumulation of somatic mutations in a number of different genes characterizes the process of tumorigenesis. Many genes involved in the process of tumorigenesis are components of one of a great many signal transduction pathways through which signals traffic via molecular networks. It is now apparent that epithelial malignancy can in certain aspects be explained by alterations in the adhesive properties of neoplastic cells.

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Article
Surgical Treatment of Penile Fracture

Authors: Emad Hassan Mahmood
Pages: 1-4
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Abstract

This study was done in order to evaluate surgical correction of penile fracture, between 1996-2003, twenty patients [25-54] years old were studied after blunt trauma to erect penis the time between injury and presentation [2-24] hours, mechanism of injury were vaginal intercourse, masturbation and rolling on bed at early morning on erected penis. All patients underwent surgical correction as emergency condition by degloving of skin of the penis with suturing of injured corpus. All injury were unilateral corporeal,no urethral injury follow up of the patients show adequate erection in all cases with no curvature. Early surgical correction of rupture corporeal injury give good result with nearly no complications.

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Article
Cervical Lymphadenopathy in Children . A Pathological Study in Mosul

Authors: Rafah S. Al-Saadoon
Pages: 5-9
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Abstract

Cervical lymph node are the most frequently enlarged and biopsies of all peripheral lymph node affecting all age groups including children. The aim of the study was to find the main cause of cervical lymphodenopathy in children and to compare the result with other studies. This study was conducted in Alzahrawi Teaching Hospital Ands three private laboratories in Mosul over 10 years period 1993-2002 which included two hundred fourteen cases. Clinical data including the age and sex in addition to the histological study of the slides were reviewed . The cervical lymphadenopathy showed distribution of [p46, 72 and 96] within the three childhood quinquennia respectively. The male : female ratio was 1.3:1. The most common histological findings were reactive hyperplasia [51.4] followed by tuberculosis [28.5%] and lymphoma [17.3%] One out of each five excised lymph node show malignant changes.. In developing countries about ½ of the cervical lymph nodes examined show significant and clinically important pathologies, there by justifying an active management of all pediatric patients with persistent CLA.

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Article
Effect of Different Caffeine Concentrations on Sperm Parameters of Asthenospermic Patients

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Abstract

The study is an attempt to improve the sperm parameters of asthenospermic patients by using centrifugation-washing technique, with Earle's balanced salt and glucosaline medium and addition three different concentrations of caffeine (0.043, 0.074 and 0.097 molar separately]. Three incubation periods (30, 45 and 60 minute) were used for all sperm activation specimens. A 0.043 molar of caffeine with Earle's or glucosaline media caused significant increase (P<0.001) in sperm motility percent and grade activity compared to the control group (Earle's or glucosaline alone) in 30 minute of incubation period also a significant differences were noticed between this concentration and other two concentrations (0.074 and 0.097 molar) when added to glucosaline in different incubation period. The results showed insignificant difference in sperm motility index between Earle's medium with caffeine and glucosaline medium with caffeine in different incubation periods and concentrations.

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Article
The Effect of Cinnamomum Verum on Serum Glucose, GOT, GPT and Creatinine in Patients With Type-2 Diabetes Mellitus

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Abstract

The possible effect of Cinnamomum verum on blood glucose was studied in patients with type-2 diabetes. Its effects on hepatic and renal function, and presence of other side effects were evaluated. Fasting blood glucose and serum GOT, GPT and creatinine levels were measured. The results shown that Cinnamomum verum produce significant decrease in serum glucose levels (P<0.05), while there was non significant changes (P>0.05) in serum GOT, GPT and creatinine levels. There was no mentioned side effect except gastric burning in one patient only

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Article
Is It Necessary to Invaginate the Appendix Stump ?

Authors: Ali A. Al-katib
Pages: 23-26
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Abstract

To assess the need for certain operative detail is not necessary especially during appendicectomy i.e.the invagination of the appendicularstump. 230 patients selected from the total of 964 patients underwent appendicectomy in Hilla teaching Hospital (Hilla-Babylon-Iraq) from 1 st of June 2000 to the 1 st of May 2001. they were divided into groups.Group I involve 110 patients in whom the appendix stump ligated invaginated. In group 11,which involve 120 patients in whom the appendix stump ligated but not invaginbated. 716 patients were excluded from the study because they needed antibiotics or the appendix was found perforated or they needed drain or the patient was diabetic or immuno-suppressed. No significant differences in both groups regarding wound infection and other complications or hospital stay. We concluded that certain operative steps are not necessary by which we may reduce operative time and reduce the need for catgut which is important to us in these days.

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Article
Effect of dialysis on bleeding diathesis in uraemic patients

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Abstract

To compare the improvement in platelet count, bleeding time and clotting time immediately after and 24 hours after haemodialysis and peritoneal dialysis . The effect of haemodialysis and peritoneal dialysis was studied in 50 patients with renal failure admitted to Merjan teaching Hospital between June 2004 to October 2004 ,platelet count , bleeding time and clotting time were studied before dialysis , immediately after and 24 hr. after dialysis . A total number of 50 patients were studied , 29 patients treated with peritoneal dialysis and 21 patients treated with haemodialysis . Mean percentage of improvement in platelet count in peritoneal dialysis was 2.1% immediately post dialysis and became 7.4 % 24 hr. post dialysis while the percentage of improvement in platelet count in haemodialysis was 7.1 % immediately post dialysis and became 25.4 % 24 hr. later. Mean percentage of improvement in bleeding time immediately after peritoneal dialysis was 11.5 % and became 20.9% 24 hr. later, while the percentage of improvement in bleeding time immediately after haemodialysis was 13.1 % and became 30.6 % 24 hr. later . Mean percentage of improvement in clotting time immediately after peritoneal dialysis was 9% and became 17% 24hr. later, while the percentage of improvement in clotting time immediately after haemodialysis was 11.6% and 24.3% 24 hr. later . This improvement in platelet count, bleeding time and clotting time immediatly after and 24hr. after both peritoneal dialysis and haemodialysis was statistically significant but the results of haemodialysis were more significant when compared with the results of peritoneal dialysis

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Article
The Hypoglycemic Effect of Some Medicinal Plants in Normal and Experimentally Induced Diabetic Rabbits

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Abstract

Alloxan (180mg/Kg] I.V is an effective diabetogenic agent that induces diabetes mellitus in rabbits. Ninety healthy male rabbits were involved in this study. The plasma glucose levels were measured in normal and in diabetic rabbits after giving alloxan and following the administration of glibenclamide, insulin and the aqueous extract of medicinal plants. Insulin (2IU/Kg] S.C produced a significant reduction in plasma glucose levels in diabetic rabbits (b= -3.87 P< 0.001]. In the mean time, the aqueous extract of Cinnamomum verum, Nigella sativa and Olea europea at a single dose of 0.5g/Kg orally caused a significant lowering of plasma glucose levels in diabetic rabbits with b=(-2.38], (-2.34 ] and (-1.17] respectively (P< 0.05], whereas the aqueous extract of both Capparis spinos and Coriandum sativum at the same dose produced non significant decrease in plasma glucose levels of diabetic rabbits with b= (-0.86] and (-0.98] respectively (P> 0.05]. The aqueous extract of medicinal plants significantly decreased the plasma glucose levels in normal rabbits except with Capparis spinos, whereas glibenclamide insignificantly reduced the plasma glucose levels in diabetic rabbits.

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Article
Management of Swallowed Foreign Body

Authors: Ali A. AL-Katib
Pages: 45-49
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Abstract

Two boys, aged 9 & 2 years who had each swallowed a nail are reported. Both nails were iron and about 5 cm long; one had a pointed end, the other was blunt at both ends. Conservative expectant treatment was successful. The nails passed out in 50h in one case & 120h in the other without causing ill effects. The different types of swallowed foreign bodies in the gastro-intestinal tract, their clinical features, methods of diagnosis and management, with possible complications are described.

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Article
Indirect Assessment of Endothelial Function in Patients with Hypertension and Diabetes Mellitus

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Abstract

Thirty eight participants (27 men, 11 women) with age between 40-60 years were divided into 3 groups. Group I: Includes 13 healthy subjects. Group II: Includes 13 patients with essential hypertension. Group III: Includes 12 patients with type 2 diabetes mellitus. Using high-resolution ultrasound, brachial artery diameters at rest, during reactive hyperaemia (endothelium-dependent dilation] and after sublingual glyceryl trinitrate (GTN) application (endothelium-independent dilation) were measured. The percentage increase of brachial artery diameter after reactive hyperemia (flow-mediated diltation% or FMD%) in control subjects was 8.85 ± 0.25% while it was found to decrease significantly (P<0.0001) in hypertensive and diabetic patients by 60% and 67% respectively. Furthermore, the percentage increase of the brachial artery diameter after glyceryl trinitrate (glyceryl trinitrate-induced dilatation% or GTNID %) in control healthy subjects was 14.41 ± 0.81%. The GTNID% was found to decrease significantly (P < 0.006)by 25% in hypertensive patients. No significant GTNID% change was found in diabetic patients. The antioxidant-oxidant ratio index (RI)of the measured biochemical parameters was significantly lower in hypertensive patients (by 50%)and even more lower in diabetic patients (by 84%) The antioxidant-oxidant RI was found to be significantly and posiviely correlated with FMD% and GTNID% in diabetic patients only.

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Article
Serum Fructosamine and Related Biochemical Parameters in Pregnant Women with Pre-Eclampsia

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The objective of this study is to determine the pattern of change in serum fructosamine and related biochemical parameters in normally pregnant women and to compare them with pregnant women complicated with pre-eclampsia and also to examine the influence of serum albumin or total protein on fructosamine concentrations with the need for correcting their values accordingly. Fasting plasma glucose (FPG) and serum fructosamine (FAm), albumin and total protein were measured in three groups of women who were attending Al-Batool antenatal clinic and Al-Khansa antenatal clinic in Mosul during the period of 7 months from 1 st November 2000 to 31 st May 2001. These included 250 non-pregnant apparently healthy women (group 1), 242 normally pregnant women (group 2) and 53 pregnant women complicated by pre-eclamptic toxaemia (group 3). The distribution of serum FAm in group 1 showed a normal (Gaussian] pattern with reference range calculated as mean ± 2SD of 1.37-2.49 mmol/L. In group 2, a significantly lower FAm values were observed (Z=4.1, p<0.001) with no significant correlation between FAm and albumin or total protein. There was a downward trend in FAm values with the progress of pregnancy as their means were (1.82, 1.80, 1.77 mmol/L) in the early, middle and late stages respectively which were significantly lower than the mean value of 1.93 mmol/L in group 1. Serum albumin and total protein showed also a trend to decrease during the gestational stages with a highly significant difference from group 1 (p<0.001). FPG showed no significant difference in all stages from group 1. Correction of FAm for albumin or total protein is required in group 2 and comparison between corrected fructosamine (FAc) in group 1 and group 2 revealed no significant difference. In group 3, lower FAm values were obtained with mean ± SD of 1.60 ± 0.27 mmol/L, which is significantly (p<0.001) lower than group 1 (Z=6.2) and group 2 (Z=3.4). There was also a tendency for mean FAm to decrease with the increase in the degree of proteinuria. Following correction according to albumin or total protein, the difference was eliminated as compared with group 2, but in comparison with group 1 the difference was eliminated only when correction according to total protein was made. These data highlight the importance of measuring serum fructosamine in women during pregnancy. Its concentration is affected by the changes in serum albumin and total protein during the different stages of gestation. In pregnancy complicated by pre-eclamptic toxaemia, correction of fructosamine according to albumin or total protein, is mandatory as the values differ from those in non-pregnant and normal pregnant women.

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Article
The Pattern of Gastric Mucosal Cells in Peptic Ulcer Patients

Authors: Hassan G. AL –Awady
Pages: 76-79
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This study aimed to investigate the pattern of gastric cells count in peptic ulcer patients. 200 patients with peptic ulcer disease were included in this study, 160 of them have Du and 40 of them have GU. Eighty normal subjects were considered as control group .We had performed gastric antral, and gastric body mucosal biopsy for all these patients with peptic ulcer and including the control group in order to study the histopathological pattern of gastric mucosal cells. The results, of this study showed that the parietal cells count significantly (P< 0.01) higher in duodenal ulcer patients than normal control group and also significantly lower in gastric ulcer patients than control group. There was no significant difference in parietal cells counts in peptic ulcer patients wether infected with H-pylori or non infected with H.pylori . Also the chief cells count was significantly (P<0. 05) higher in duodenal ulcer patients than control and was significantly Lower in gastric ulcer patients than control . H-pylori infection has no effect on chief cells count in Du and Gu patients than control group . mucous cells count was significantly (p0.05) in D- cells and G-cells count between duodenal ulcer patients and control group, but there was a significant decrease in D- cells and G-cells count in gastric ulcer patients than control . H.pylori infection has no effect on D- cells and G- cells count in peptic ulcer patients .

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Article
The value of diagnostic OGD in surgical patients

Authors: Zuhair Ibrahim Hasoon Al-yasi
Pages: 80-83
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Abstract

This study includes the analysis of three thousand diagnostic OGDs done by surgeons at Al-Hilla teaching Hospital for the diagnosis of diseases causing complaints related to upper GIT and for pre-operative checking and preparation of patients prior to surgical interference. This study has shown a great change in the behavior of peptic ulcer disease as compared with its behavior in the period prior to this study where a significant increase in the number of patients with duodenal ulceration. Mean while, a striking increase in the number of females having complicated peptic ulceration. The study has also shown the rarity of multiple duodenal ulceration (kissing ulcers) in females as well as the rarity of gastric and oesophageal cancers. Posterior D.Us are uncommon as compared with anterior ones a fact, which arouses the thinking of some protective mechanism. The concomitant occurrence of gallbladder disease with D.Us is also noticed. GERD and its complications is also strikingly uncommon in this study. The number of negative examinations (normal patients) is high in this collection despite the selection of patients we adopted for OGD examination, a fact that made us think of a better selection scale (predicting scale).

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Article
Lack of Progress in Labour as a Reason for Cesarean

Authors: Bushra J. Alrubaii
Pages: 84-90
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To estimate the prevalence of lack of progress of labor as a reason for Cesarean delivery and to compare it with other studies. We collect data from 1661 women who delivered full term , non breech infants , by unplanned Cesarean between Jan. 2002 – Jan . 2003, in Babylon Maternity and Pediatric Hospital. There were a subset of 9551 births sampled at delivery . We measured the proportion of unplanned Cesarean done for lack of progress in labor, the cervical dilatation at the time of Cesarean ,length of the second stage and slope of the active phase among the women. Lack of progress was a reason for 69% of unplanned vertex Cesareans. At least 15% of the subjects who had Cesareans for lack of progress were in the latent phase of labor .The second stage of labor was not prolonged in 32% of women who women who delivered at 10cm . Lack of progress in labor is a dominant reason for Cesarean delivery. Many Cesareans are done in the latent phase of labor and in the second stage of labor when it is not prolonged.

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Article
Morphological Changes of Proximal Segment of Fallopian Tube after Injury

Authors: Mohammed U. Hamza
Pages: 91-98
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The type of regeneration of the fallopian tube was different in various oviduct segments with regards to their response to tissue injury i.e. the proximal segment (isthmus] regenerated by activation of epithelium which invade the submucosa or muscularis layer leading to the formation of fistula. This type of regeneration of tubal epithelium affect the prognosis of tubal surgery on both proximal and distal segment and its relation to ectopic pregnancy after tubal injury.

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Article
Immunology of Staphylococcal Human Persistent Pyuria

Authors: Baha,H .Al- amedi --- Ibrahim M.S.Shnawa
Pages: 99-104
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Abstract

Fifteen Staphylococcus aureus isolates from human with persistent pyuria were diagnosed .Patient had high total serum protein (7.178 g/dl) , high serum (4.081 g/dl) and mucosal globulins concentration (0.072 g/dl] and lowered serum albumin globulin ratio (56.68%) in comparison to normal subjects. These patients were with significant anti S . aureus specific agglutinins both at serum and mucosal secretions . Their peripheral and mucosal leucocyte migration inhibition (LIF) were significant (peripheral 0.5, mucosal 0.58) .Non significant anti S. aureus agglutinins and LIF were noted in blood and secretion of five immunecompromized, these five cases were showing low grade (specific antibody titre 40, LIF, peripheral 0.8, mucosal 0.75) immune responses due an immunocompromy. The involved immunodominant epitopes in these immune responses may be T dependent types that can activate either or both Th1,Th2 . For humoral arm direct B cell epitope maybe expected also

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Article
Study of Cytokeratins Markers in Breast Carcinomas

Authors: Ali Hassan AL–Timimi
Pages: 105-113
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Abstract

While several prognostic factors have been identified in breast carcinoma, the clinical outcome remains hard to predict for individual patients. Better predictive markers are needed to help guide difficult treatment decisions. In previous studies of breast carcinoma specimens, an association between poor clinical outcome and the expression of cytokeratin markers 17 and/or cytokeratin 5 mRNAs was noted. Here we describe the results of immunohistochemistry studies using monoclonal antibodies against these markers to analyze 55 paraffin-embedded breast tumors. We found that expression of cytokeratin markers 17 and/or cytokeratin 5/6 in tumor cells was associated with a poor clinical outcome. Moreover, multivariate analysis showed that in node-negative breast carcinoma, expression of these cytokeratins markers were a prognostic factors independent of tumor size and tumor grade.

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Article
Effect of Aqueous Extract of Some Medicinal Plants on Plasma Lipid Profile in Diabetes Induced Rabbits

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Alloxan (180mg/kg) i.v is a potent diabetogenic agent that induces diabetes mellitus in rabbits with hypercholesterolemia and hypertriglyceridemia . Fifty-four healthy male rabbits were involved in this study. Both plasma cholesterol and triglyceride levels were measured before and after giving alloxan and following administration of insulin, glibenclamide or aqueous extract of medicinal plants. Insulin (2 IU/kg) S.C produced a significant reduction in both plasma cholesterol (b=-1.05 p<0.005] and triglyceride levels (b=-1.19 P<0.01) whereas glibenclamide (70mg/kg) per Os produced no significant changes in these values. In the mean time the aqueous extract of Nigella sativa (0.5g /kg] produced a significant decrease in both cholesterol and triglyceride levels with (b=-0.65 P<0.05) and (b=-1.28 P<0.05) whereas Capparis spinos caused a significant decrease in plasma cholesterol levels only with (b=-0.83 P<0.01). Finally the extract of Coriandrum sativum ,Oleoe uropea and Cinnamomum verum produced a significant reduction in triglyceride levels with (b=-1.12 P<0.05),(b=-0.97 P<0.05) and (b=-1.01 P<0.01) respectively but with no significant change in cholesterol levels. There is no significant correlation between the hypoglycemic effects of medicinal plants and their hypocholesterlemic & hypotriglyceridemic effect. Also the possibility of using Nigella sativa and Cinnamomum verum for diabetic patients with type- ll but this needs more clinical trials. Keyword cholesterol, triglyceride, medicinal plants

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Article
A survey of Dermatophytoses in Hilla

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From 160 patients with dermatophyte-infections; Tinea pedis & Tinea cruris had showed a high rat of infection. Five species of Trichophyton, in addition to some yeast growth were diagnosed. Negative growth of specimens culturing was represented 23.12 % from all patients no. , in spite of clinical diagnoses of dermatophytoses .Males show higher incidence in the No. of Tinea infection than females.

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Article
Serum Vitamin C Status In children with Type I Diabetes Mellitus

Authors: Ahmed K. Hamza --- Salem Rahma --- Lamia M. AL-Naama
Pages: 123-131
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Serum vitamin C status was studied in 50 children (29males and 21females) with insulin dependent diabetes mellitus admitted to Basrah maternity and children hospital, from the period of June 2001 till May 2002. 54 healthy children (31 males and 23 females) admitted to the same hospital with acute illnesses like chest infection were randomly selected as a controls. Low serum vitamin C level was detected in (44%) of diabetic children compared to (7.41%) of the control group which was highly significant (P<0.001). The two groups differ significantly in the frequency of consuming fruits per week and serum C-reactive protein (P<0.01). In diabetic children with low serum vitamin C level, the frequency of fruit consumption per week was significantly lower than those with normal vitamin C level. In regard to serum C-reactive protein,(70.6%]of positive cases were presented in children with low serum vitamin C level while only(29.4%]of positive cases occurred in those with normal serum vitamin C level. There was no association between serum vitamin C and degree of glycemic control. After adjustments for differences in dietary intake of vitamin C and C-reactive protein, children with diabetes had significantly lower serum vitamin C concentration than did children without diabetes.

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Article
Idiopathic Thrombocytopenic Purpura and Diabetes Mellitus

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A 26 years old man presented at April 2004 with petechiae of both upper and lower limbs associated with polyuria, polydipsia and weight loss. Two days later he consulted a dermatologist who diagnosed him as idiopathic thrombocytopenic purpura (I.T.P.) and treated him with (prednisolone tablet 30 mg/day). On examination the patient looked ill, with multiple petechiae and puppuric spots, no lymphadenopathy or hepatosplenomegaly

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Table of content: volume:2 issue:1