Table of content

Al-Kindy College Medical Journal

مجلة كلية الطب الكندي

ISSN: 18109543
Publisher: Baghdad University
Faculty: Al-Kindy Medicine
Language: English

This journal is Open Access

About

Al-Kindy College Medical Journal ((Al-Kindy Col.Med.J)), a periodic peer reviewed scientific journal published biannually by Al-Kindy College of Medicine –University of Baghdad. specialised
in research of medical and related subject ISNN 1810-9543
The articles and research studies published in the journal are carefully selected and reviewed by a high standard advisory board from doctors who are most seniors and experts in their medical fields according to the subjects submitted to the journal.
Al-Kindy Col.Med.J is well recognized by Baghdad ,Mustansiriya and Nahrain universities for promotion of their teaching staff.
Three hundred articles ,research papers, case reports and studies have been published ourn medical journal since 2003 till now and the journal has been distributed to all medical collages of Iraq and most counties in the Middle East.

Loading...
Contact info

Mobile: +964 7803546157
web site: www.kmc.edu.iq
E-mail: journal@kmc.uobaghdad.edu.iq
info@kmc.uobaghdad.edu.iq

Table of content: 2011 volume:7 issue:1

Article
Cesarean Section Rates At Al-Batool Maternity Teaching Hospital

Loading...
Loading...
Abstract

Objectives: To report the Cesarean section rate in Al- Batool Maternity Teaching Hospital and to identify how many of them were done for maternal and fetal condition. Design: A statistical cross sectional study. Setting: The study was conducted at Al-Batool Maternity Teaching Hospital (13000 deliveries per year). Participants: The patients group consists of 4556 patients admitted for delivery (vaginal and abdominal) during a period of four months commencing from January 2003. Main outcome measures: calculation of all live births, calculation of cesarean section rate, percentage of the primary cesarean sections and the repeat cesarean sections and listing the indications of the operation according to maternal and fetal condition with their percentage. Results: Total births during the period of this study were 4556 births, 3732 vaginal deliveries and 824 cesarean sections. Cesarean section rate was found to be 17.94% of total live births, the most frequent indication for cesarean section was malpresentation (24.3%). Primary cesarean sections contribute to 75% of cases. Conclusions: A primary cesarean section is one of the most important causes of high cesarean section rate. Decreasing the incidence of primary operations will help in reducing cesarean section rate.


Article
Metabolic syndrome in women with polycystic ovary syndrome

Loading...
Loading...
Abstract

Objectives: To report the Cesarean section rate in Al- Batool Maternity Teaching Hospital and to identify how many of them were done for maternal and fetal condition. Design: A statistical cross sectional study. Setting: The study was conducted at Al-Batool Maternity Teaching Hospital (13000 deliveries per year). Participants: The patients group consists of 4556 patients admitted for delivery (vaginal and abdominal) during a period of four months commencing from January 2003. Main outcome measures: calculation of all live births, calculation of cesarean section rate, percentage of the primary cesarean sections and the repeat cesarean sections and listing the indications of the operation according to maternal and fetal condition with their percentage. Results: Total births during the period of this study were 4556 births, 3732 vaginal deliveries and 824 cesarean sections. Cesarean section rate was found to be 17.94% of total live births, the most frequent indication for cesarean section was malpresentation (24.3%). Primary cesarean sections contribute to 75% of cases. Conclusions: A primary cesarean section is one of the most important causes of high cesarean section rate. Decreasing the incidence of primary operations will help in reducing cesarean section rate.


Article
The Role of Aspirin as Otoprotective Agent in Patients Receiving Amikacin Therapy

Authors: Estabraq M. Mahdi Msc
Pages: 11-13
Loading...
Loading...
Abstract

Objective: To investigate and prove that aspirin protects, or at least attenuates amikacin ototoxicity in humans. Method: This study was conducted in 60 patients that completed all requirements .The patients were divided into two groups: • Control group: receive placebo treatment. • Drug–treated group: They receive aspirin coated tablets (1.5gm/ day), 500mg 8 hourly. Both groups had similar aspects regarding the gender, age and weight. The duration of therapy was 7 days and dosage of amikacin was 1gm/day (500mg 12 hourly). Results: Comparison of Audiometry test in Ear/Nose/Throat (E.N.T.) Department (Pure Tone Audiometry) at 1000 Hertz (Hz), 2000 Hz, 4000 Hz, and 8000 Hz showed significant differences between mean Audiometry at 250Hz was significantly different only at 8th and 15th day while at the frequency of 500Hz the difference was significant at the 15thday only. Conclusion: In present study, we had shown that aspirin can protect the patients who are receiving amikacin therapy from it' s ototoxicity.

Keywords

Aspirin --- amikacin --- Pure Tone


Article
Local Expression of MMP-7 in Oral Cancer

Authors: Manal A. Habib منال حبيب
Pages: 14-17
Loading...
Loading...
Abstract

Background: Squamous cell carcinoma of the oral cavity (OSCC) is a highly invasive neoplasm. Many MMPs play role in human cancer invasion and metastases. Aim: Estimating The MMp-7 expression level in HPV-16 positive and HPV-16 negative OSCC paraffin embedded sections. Method: Biopsies from thirty three patients with oral squamous cell carcinoma (OSCC) were obtained and investigated for the presence of HPV-16 RNA with the application of ISH and the MMP-7 expression level using IHC . Results: Expression level of MMP-7 found to be high in OSCC sections 29 (87.8%) cases with no significant difference in its expression level between HPV-16 positive and HPV-16 negative OSCC cases p= 1.00. Conclusion: MMp-7 found to be expressed in high level in OSCC with no significant relevance to HPV- 16.


Article
THE EFFECT of PINEALOCTOMY on the DEVELOPING SUPERIOR Cervical GANGLION of the RAT

Loading...
Loading...
Abstract

Back ground: In the present study Pinealoctomy was used to study the sympathetic innervations of the pineal gland by the superior cervical ganglion (SCG) of the albino rat. Objective: Following Pinealoctomy, it is expected to observe the Chromatolysis reaction in some neurons of the SCG if they were to innervate the pineal gland (i.e. retrograde Chromatolysis changes). Methods: Fifty albino rats were used in this study, Pinealoctomy was done, then after a different time interval ganglionectomy was done, in order to study the Chromatolysis in their cell body. Result: The present study has demonstrated that the most obvious Chromatolysis reaction in the neurons which innervate the pineal gland appeared one day following Pinealoctomy in the young and adult rats. In the SCG of animal, one week following Pinealoctomy, the number of the Chromatolysis neurons was much less than these seen in the previously mentioned one day animals. In (2 – 6) weeks following Pinealoctomy, the number of the Chromatolysis neurons kept a constant decline. Conclusion: The work presented in this study showed that the method of tracing the innervations of the pineal gland by removing the target tissue (the pineal gland in this study) appeared to be justified and conclusive. It has also shown that younger animals, subjected to Pinealoctomy, would react more vigorously with respect to Chromatolysis than adult animals. The present study has also demonstrate that the distribution of these Chromatolysis neurons and for all age groups all over the ganglion being inspected. However they were more abundant in the rostral 2/3 of these ganglions.


Article
Antenatal diagnosis of myometrial invasion in anterior placenta previa by transabdominal color Doppler ultra sound

Loading...
Loading...
Abstract

Background: The incidence of maternal mortality in placenta previa accrete is 7%,and its preoperative diagnosis is of a great value. Objective: to evaluate the efficacy of transabdominal color Doppler ultrasound in diagnosing placenta previa accreta and inccreta. Color Doppler imaging criteria used in: includes diffuse parenchymal placental lacunar flow, focal intra parenchymal placental lacunar flow and bladder uterine serosa interphase hyper-vascularity. Design: Prospective study on patients from January2007 to January 2008. Patients and method: 48patients with one caesarean section or more and with persistent anterior placenta previa diagnosed by transabdominal ultrasound were examined by color Doppler at 32 or more weeks of gestation to determine the possibility of myometrial invasion depending on the above color Doppler criteria. Results: Out of 48 patients eleven exhibited characteristic Doppler imaging pattern highly specific for placenta accreta and inccreta according to preceding criteria , one patient had false positive color Doppler imaging result, 5 patients underwent caesarian hysterectomy , the remaining five were treated conservatively by uterine artery ligation and other conservative measures because of bleeding from the lower uterine segment. Conclusion Color Doppler sonography is highly sensitive and specific in the antenatal diagnosis of placenta previa accreta .If a strong suspicion is found before delivery ,appropriate location and timing for delivery should be considered ,to allow access to adequate surgical personel and equipment ,preoperative blood preparation to reduce morbidity and mortality. Journal title Ultrasound in obstetric and gynecology ISSUN 0960- 7692 Source 2000 Vol 15 In 1 PP. 28-35 (22rel)


Article
Effect of war on treatment of pulmonary tuberculosis, and evaluation of Directly-observed therapy in Baghdad

Loading...
Loading...
Abstract

Background: Directly observed therapy-short course (DOTS) had been adopted by World Health Organization (WHO) as hopeful strategy for treatment of tuberculosis (TB) since early nineties. Iraqi health authorities started DOTS implementation since 2001 in Baghdad. Coverage expanded gradually till 100% in 2004. War and unstable security condition hit Iraq since March 2003. Objective: The objective of this study was To evaluate the DOTS implementation program in Baghdad in different periods including 2 unstable periods for proper assessment of war and instability on treatment of TB. Patients and methods: This study had been conducted in Baghdad during four different periods (before and during 2003 war, after war; without and with DOTS). Direct interview with patients, and follow up of their treatment were done. Results: The results reveled that78% of patients were in active age groups, 62% of them were males. Surprisingly, direct observation was not achieved in those who were treated under DOTS in the whole periods. Patients treated under DOTS in the 1st and 4th periods showed much better sputum conversion rate after 2 month treatment (88.7 %in 1st and86.5% in 4th periods` patients) than those treated under DOTS during war (45.9% or Non-DOTS 75.6%). A better cure rate also found in patients of both periods (64.9% in 1st and 63% in 4th period) than patients in other periods ( 11% in 2nd% and 43.6% in the 3rd one) . Conclusions: DOTS strategy played important role in improving registration and curing of TB cases in Baghdad. War and unstable security conditions got a destructive effect on treatment of TB patients regardless the followed strategy. Involvement of private medical sector and other governmental and nongovernmental organization can improve TB treatment outcome.

Keywords

DOTs --- TP --- Baghdad


Article
Asymptomatic Bacteriuria in Pregnant and Diabetic Women

Loading...
Loading...
Abstract

Background: Asymptomatic bacteriuria (ASB) is defined as isolation of a specified quantitative count of bacteria in an appropriately collected urine specimen from an individual without symptoms or signs of urinary tract infection. Aim of study: To evaluate the frequency of bacteriuria according to age, pregnancy, and type II diabetes mellitus in a sample of Iraqi women. Patients and Methods: A total of 125 female individuals were involved. The study participants were classified into the following groups: non-pregnant women with type II diabetes mellitus, pregnant women with type II diabetes mellitus, pregnant women without type II diabetes mellitus, and apparently healthy non-pregnant women. Urine and blood specimens were tested to record positive urine culture, pyuria, and blood glucose according to standard microbiological and biochemical methods. Results: Frequency of positive urine culture and pyuria in the total pregnant women was 7 (14%) and 15 (30%), respectively, whereas frequency of positive urine culture and pyuria in the total diabetic women was 8 (16%) and 23 (46%), respectively. The bacterial isolation rate in the studied groups was 13 (10%). E-coli recorded the highest isolation rate, 6(5%). There was no significant culture positive of urine specimens in the groups of diabetic non-pregnant, diabetic pregnant, and women with normal pregnancy (P-value< 0.05). Pregnant women with culture positive urine and pyuria were more likely to have perinatal mortality. Sterile pyuria was detected in pregnant women aged 18-45, those in third trimester, and in multiparous pregnant women. There was significant positive urine culture and a highly significant pyuria in diabetic women with BMI > 25. Conclusions: Asymptomatic bacteriuria is an independent risk factor for perinatal mortality. Sterile pyuria is a significant observation in pregnant and diabetic women; therefore it should bring more attention. Recommendations Treatment of asymptomatic bacteriuria is appropriate for pregnant women but it is not recommended for diabetics. The study advised to perform urine culture as a part of the antenatal check-up for pregnant women.


Article
Inhibitory Effect of Aqueous Salvia officinalis’s leaves in the Growth of Candida albicans from Infected Women with Vaginal Candidiasis

Loading...
Loading...
Abstract

Background : Salvia officinalis is a plant belong to Labiatae family .The common name of Salvia is sage which mean save. The leaves of Salvia have special oil which is effective against filamentous fungi and yeasts such as Candida albicans which is the causative agent of vaginal candidiasis in women Methods . Cultures from 50 swabs of Candida albicans isolated from vagina of 70 patient women who complains from vaginal problems, their ages (24-43) years from Central City Hospital during Febreoury 2009 to April 2009 were cultured on Sabouraud Dextrose Agar (SDA) .Nystatin was used as positive reference standard to determine the sensitivity of this fungus . and less this concentration there was no minimum inhibition for the Candida Results : The aqueous extract of Salvia officinalis at various concentrations inhibited the growth of C. Albicans . This inhibitions reached to a maximum of 100% for extract at 25 mg / ml and the minimum inhibition was 170 mm at 15 mg /ml for the extract . While the minimum and maximum inhibition for nystatin was at 50 µg/ml,and less concentration. There was no minimum inhibition for the Candida Conclutions : The findings provide support for the use of this plant in traditional medicine for fungal infections especially against candidiasis .


Article
Fetal macrosomiaMaternal and Perinatal outcome

Loading...
Loading...
Abstract

Background: Fetal macrosomia represent a continuing challenge in obstetrics and increasing in it's occurrence as well as it is associated with maternal and perinatal complications. Objective: To determine the maternal and perinatal outcome related to fetal macrosomia. Design: A prospective case control study. Patients and methods: (10th March-31st May, 2006 A prospective case control study had done over the period from 10th March to 31st May, 2006 in Al-Batool maternity teaching hospital in Mosul city. The study group consisted from 633 singleton alive newborns with gestational age ≥37weeks weighing 4000 grams and heavier and mothers of these newborns compared with control group which consisted from 4155 singleton alive newborn with gestational age ≥37weeks weighing 2500-3999 grams and mothers of these newborns. The obstetrical outcome variables which compared between the two groups include mode of delivery, indication of caesarean section and maternal and perinatal complications. Results: Macrosomic newborns (≥4000grams) delivered in this study account for (12.45%) of total deliveries. Newborns with a birth weight of ≥4500grams constitute 2.65% from all deliveries. Male Newborns (65.24%) was higher and statistically differed among the study group (p value=0.001). Instrumental vaginal delivery (P value=0.010,Odd ratio: 2.12, 95% CI: 1.19-3.76) and cesarean section delivery (P value=0.000,Odd ratio:1.63, 95% CI: 1.34-1.98), mainly the emergency cesarean section (18.79%), were significantly different among the study group. Failure of progress of labour and cephalopelvic disproportion were the main indications in study group and showed statistical significant difference between the two groups. Among the study group, there was neither maternal death nor uterine rupture but there was higher occurrence of postpartum hemorrhage, genital tract trauma and shoulder dystocia which were significantly different when it compared with control group. Erb's palsy was the main perinatal complication and was statistically different among macrosomic group (P value=0.000). Conclusion: Fetal macrosomia was associated with higher rate of instrumental vaginal delivery and caesarean section mainly due to failure of progress of labour and cephalopelvic disproportion. There were higher rate of postpartum haemorrhage, genital tract trauma as well as shoulder dystocia with neither maternal death nor uterine rupture in study group. Among macrosomic newborn, Erb's pulsy was the main perinatal complication.


Article
Are Indications For Esophago Gastro Duodenoscopy Properly Followed?

Loading...
Loading...
Abstract

Background: Symptoms related to the upper gastro-intestinal tract are very common. Attribution of these symptoms to upper G. I. T. diseases are usually done on clinical bases, which could be confirmed by Esophago Gastro Duodenoscopy (EGD). The use of such tools might increase the diagnosis accuracy for such complaints. The indications for upper G I endoscopy might decrease the negative results of endoscopies. Objective: To follow strict indications for Esophago Gastro Duodenoscopy in order to decrease the negative endoscopy results. Methods: One thousand eight hundred and ninety cases were subjected to EGD from Feb. 1999 to Feb 2009 at Alkindy Teaching Hospital and Abd-Al-Majeed private hospital in Baghdad, Iraq. A special endoscopy unit form was prepared containing data from patients, clinical complaint, indications for endoscopy request, and the endoscopic diagnosis, biopsies were taken when indicated and subjected to histopathological examination. All these data were studied and analyzed. Results: Out of the total 1890 patients there were 1114 males and 776 females with male to female ratio 3/2, the most common age group ranged from 21 to 50 years with a mean age of 32 years. Upper abdominal pain was the most common indication (30%), upper GI bleeding (27.94%), duodenal ulcer follow up (25.5%). The diagnosis of chronic DU was established in (40.21%) of cases, normal endoscopic results were found in (34.6%), duodenitis and gastritis in (15.2%). Conclusion: The high number of normal gastrointestinal endoscopies necessitates the need to follow strict indications before subjecting the patients for endoscopy.


Article
Prevalence of clinically significant Hepatopulmonary Syndrome among Patients with Chronic Liver Disease and Portal Hypertension

Authors: Sadiq Almohana صادق المحنا
Pages: 61-66
Loading...
Loading...
Abstract

Background : The hepatopulmonary syndrome (HPS) is defined as the triad of liver disease, arterial deoxygenation, and pulmonary vascular dilatation. The reported prevalence of HPS in cirrhotic patients varies between 5% -17.5%. Objective : To estimate the prevalence of hepatopulmonary syndrome among patients with chronic liver disease and portal hypertension and to study the correlation between HPS and the severity of liver disease. Patients and methods : Thirty patients were studied for the presence of HPS using transthoracic contrast echocardiography for detection of pulmonary vasodilatation. Arterial oxygen saturation (SaO2) was determined in erect and supine position using a pulse oximeter , (SaO2 ≤ 92 % in supine position and/or a decrease of ≥ 4% after change from supine to upright position) to detect hypoxia and ortheodeoxia. Result : Eleven of thirty patients (36.6%) with chronic liver disease and portal hypertension were found to have contrast echocardiographic evidence of intrapulmonary right-to-left shunting. Arterial oxygen desaturation was present in 3 patients (27.3%) of those with intra-pulmonary right-to-left shunting ,they were considered as clinically significant HPS ,the remaining 8 patients were considered as subclinical HPS. Dyspnoea was more often present in patients with clinically significant HPS (100%) compared with subclinical HPS (25%), and patients without HPS (9%). HPS correlated significantly with severity of liver disease according to the Child-Pugh score. Conclusion: hepatopulmonary syndrome is not uncommon , the prevalence of clinically significant hepatopulmonary syndrome (in this study) was 10% of patients with chronic liver disease and it correlated with disease severity according to the Child-Pugh score.


Article
Early Outcome of Bifurcational Coronary

Authors: Ahmed Y. Bedair احمد بدير
Pages: 67-70
Loading...
Loading...
Abstract

Background : The hepatopulmonary syndrome (HPS) is defined as the triad of liver disease, arterial deoxygenation, and pulmonary vascular dilatation. The reported prevalence of HPS in cirrhotic patients varies between 5% -17.5%. Objective : To estimate the prevalence of hepatopulmonary syndrome among patients with chronic liver disease and portal hypertension and to study the correlation between HPS and the severity of liver disease. Patients and methods : Thirty patients were studied for the presence of HPS using transthoracic contrast echocardiography for detection of pulmonary vasodilatation. Arterial oxygen saturation (SaO2) was determined in erect and supine position using a pulse oximeter , (SaO2 ≤ 92 % in supine position and/or a decrease of ≥ 4% after change from supine to upright position) to detect hypoxia and ortheodeoxia. Result : Eleven of thirty patients (36.6%) with chronic liver disease and portal hypertension were found to have contrast echocardiographic evidence of intrapulmonary right-to-left shunting. Arterial oxygen desaturation was present in 3 patients (27.3%) of those with intra-pulmonary right-to-left shunting ,they were considered as clinically significant HPS ,the remaining 8 patients were considered as subclinical HPS. Dyspnoea was more often present in patients with clinically significant HPS (100%) compared with subclinical HPS (25%), and patients without HPS (9%). HPS correlated significantly with severity of liver disease according to the Child-Pugh score. Conclusion: hepatopulmonary syndrome is not uncommon , the prevalence of clinically significant hepatopulmonary syndrome (in this study) was 10% of patients with chronic liver disease and it correlated with disease severity according to the Child-Pugh score.


Article
Serum Lipoprotein (A) in Patients with Fibromyalgia Syndrome

Loading...
Loading...
Abstract

Background: Fibromyalgia syndrome (FMS) is the most common rheumatic cause of diffuse pain and multiple regional musculoskeletal pain and disability. Objective: is to assess the contribution of serum lipoprotein (A) in the pathogenesis of FMS patients. Methods: One hundred twenty two FMS patients were compared with 60 healthy control individuals who were age and sex matched. All FMS features and criteria are applied for patients and controls; patients with secondary FMS were excluded. Serum Lipoprotein (A): [Lp(A)], body mass index (BMI), & s.lipid profile were determined for both groups. Results: There was a statistical significant difference between patients &controls in serum lipoprotein (A) (P=0.013). Also there was a statistical significant correlations between serum Lp(A) & FMS patients' age( r= 0.310, P=0.034 ); but not with: duration(r= -0.222, P=0.133) , BMI(r= 0.128,P=0.390) & s.lipid profile ( p> 0.05) of FMS patients. Conclusion: s.lipoprotein (A) may play an important role in pathogenesis of FMS patients.


Article
Tympanogenic Labyrinthitis (Cochlear Deafness) due to chronic suppurative otitis media (CSOM)

Loading...
Loading...
Abstract

Background: It has been accepted that in patients with CSOM, conductive deafness results from mechanical break-down of sound conduction ,whilist the cochlea remains unaffected. Objectives: Our study aims to prove a sensorineural component in hearing loss in patients suffering from CSOM , which necissates early detection as it increases in severity with time. Methods: A prospective study was done on 64 patients, all were diagnosed as having unilateral CSOM, their ages ranged from 18-40 years to exclude presbyacusis as a cause of sensorineural deafness. These patients were divided into 4 groups according to the duration of discharge and further divided into 3 groups according to the pathology (simple perforation, granulation tissue or cholesteatoma). Results: 62 patients showed some degree of sensorineural deafness in the affected ear accounting for 96.8% of the total number of patients, While only 2 patients escaped the phenomenon. Worsening of bone conduction thresholds was noticed with increased duration of the disease. The highest loss was in patients with severe pathology (cholesteatoma) and least in those with simple perforation. Conclusion: This study indicates that the degree of sensorineural hearing loss in patients with CSOM relates with the duration and complications of the disease which is contrary to the traditionally accepted belief of the physicians that cochlea remains unaffected in CSOM. Key words: Cochlea, sensorineural deafness, CSOM


Article
The Expression of Epstein-Barr virus in Breast cancer in relation to age

Loading...
Loading...
Abstract

Background: Breast cancer is the most common malignancy affecting females worldwide. The association of Epstein-Barr virus (EBV) with this cancer is a long-standing interest to this field. Aim: to investigate the presence of EBV in breast tumor tissue in relation to age. Patients and Methods: Paraffin-embedded tissue blocks from 45 female patients with breast tumors (ranged in age from 28 to 85 years) were retrieved. The cases were grouped into two categories: group (A): included 30 cases with breast carcinoma and group (B): included 15 cases with benign breast diseases as a control group .The expression of EBV protein was examined immunohistochemically. Results: Twelve (40%) of the 30 breast cancer cases (group A) were reported as positive for EBV expression and significantly higher in patients less than 40 years age (P= 0.026). Conclusion: the results of the current study might refer to the significance of EBV expression in breast tissue of young patients with breast cancer.


Article
Results of Kidney Biopsies among Adult Iraqi Patients in a Single Center

Loading...
Loading...
Abstract

Background: Patients requiring renal biopsies have various glomerular diseases according to their demographic characteristics. Objective: To study types of glomerular disease among adult Iraqi patients in a single center in Baghdad/Iraq Material and Methods: A total of 120 native kidney biopsies were studied. All biopsies were adequate and were processed for Light Microscopy. The age range of the study patients was 17-67 years, with a mean of 38.5 years. The mean follow up period was 28 weeks (4-52 weeks) Indication for biopsy included: Nephrotic syndrome (N=72; 60%), Asymptomatic proteinuria (N=21; 17.5%), acute nephritic presentation (N=17; 14.16%), asymptomatic haematuria (N=10; 8.33%). Results: Primary glomerulonephritis (GN) was seen in 102 of 120 patients (85%), focal segmental glomerulosclerosis, and membranous nephropathy were the most common histological diagnosis (33.3% and 21.5% respectively). Conclusion: The study further emphasize the need for national GN registry and long term follow up, to recognize the common pattern of GN, their natural history, the appropriate line of management, and to try to halt their progression to end stage renal disease (ESRD). Key Words: Iraq, Glomerulonephritis, Renal Biopsy.


Article
THE PREVALENCE AND CLINICAL SIGNIFICANCE OF PERINUCLEAR ANTINEUTROPHIL CYTOPLASMIC ANTIBODY IN PATIENTS WITH INDETERMINATE COLITIS

Loading...
Loading...
Abstract

Background: Indeterminate colitis (IC), a term originated by pathologists to characterize confounding histopathlogic appearance of resected mucosa, has become catch phrase for cases in which diagnostic criteria at all levels elude classification as Crohn's disease (CD) or ulcerative colitis (UC). OBJECTIVES: evaluate the prevalence of pANCA expression in the sera and its isotypes. Patients and methods: PATIENTS GROUP consisted of 60 patients (40 males and 20 females) with indeterminate colitis and their age range was (19-84 years). CONTROL GROUP consisted of 30 (15 males and 15 females) healthy volunteers and their age range was (20- 66 years). Antineutrophil cytoplasmic ( pANCA and cANCA) testing was performed by an IIF technique on ethanol fixed human EOH granulocytes as substrate (EUROIMMUNE- Germany). Sigmoidoscope and colonoscope examination were done for the patients group and biopsies were taken from the patients for histopathological examination. Results: Serological results of ANCA showed a significant increased frequency of pANCA (63.3%) in indeterminate colitis patients as compared to controls (p=0.000). The highest percentage of this pANCA titer was 1:10 (p=0.000) then 1:100 (p=0.008) and most of them was IgG (53.3%) (p=0.000). Sensitivity of pANCA was 60%, specificity of pANCA was 40%, positive predictive value of pANCA was 61.1% and negative predictive value of pANCA was 66.6%. cANCA did not demonstrated in both groups. Conclusions : pANCA was more prevalent in indeterminate colitis and could be used as a predictive serological marker for the outcome of disease.


Article
Large Epigastric Hernia: an Unusual Presentation

Loading...
Loading...
Abstract

We presented here a 65years old lady with an unusual presentation of a large epigastric hernia of twenty years duration .The swelling was occupying all the right hypochondrial region .The diagnosis was made on r^E^a-operative identification of the defect in the linea alba which was sutured after removal of the hernial sac and its contents .The postoperative course was uneventful and the patient remained with no complications or recurrence for more than two years follow up.

Table of content: volume:7 issue:1