Table of content

Iraqi Journal of Embryos and Infertility Researches

المجلة العراقية لبحوث الأجنة والعقم

ISSN: eISSN: 26166984 / pISSN: 22180265
Publisher: Al-Nahrain University
Faculty: Embryo research and treatment of infertility
Language: English

This journal is Open Access

About

Iraqi journal of embryos and infertility research is apeer-reviewed journal published annually by the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies/Al-Nahrain University,
it publishes manuscripts in the fields of reproductive medicine.

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Contact info

E-mail: haydermossa@gmail.com

E-mail: ijeir.info@ierit.nahrainuniv.edu.iq

Website : http://www.ijeir.nahrainuniv.edu.iq

Table of content: 2011 volume:1 issue:2

Article
Morphological development of the metanephric glomeruli in rat during peri-natal period
النماء الشكليائي لكبيبات الكلية البعدية في الجرذ خلال الفترة المحيطة بالولادة

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Abstract

background "The metanephric glomeruli develop from the metanephric blastema and ureteric bud. The nephron anlage undergoes multiple differentiation stages, fusion and invagination that lead to the formation of nephron. objective To describe the morphological changes and transformations that lead to formation of metanephric permanent glomerulus during peri-natal period. method The study was performed on albino rat as a model for mammalian embryonic development. Embryos of20-22 days of gestation and neonatal litters were investigated for renal development. The specimens were double fixed, plastic embedded and semi-thin sections stained with methylene blue were examined result it was shown that glomerular development oontinues during late pre-natal days and first week post-natally. Maturity was attended by the end of the 7lh post-natal day The developing glomerulus passes through the stages describes as vesicle, comma, S-shaped, double comma, elongation and ovale stage to become finally mature. conclusion The metanephric glomerulus passes through sequential, mufti-stage, pleomorphic development during peri-natal period. These features should be considered during evaluation of kidney during this period.


Article
Effects of metformin on the lipid profllein polycystic ovarian syndrome patients
تاثير عقار المتفورمين على مستوى الدهون عند مرضى متلازمه تكيس المبايض

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Abstract

Polycystic ovary syndrome (PCOS) is (be most common and prevalent endocrinopathy in women , and the most common cause of anovulatory infertility- An altered lipid profile is common in polycystic ovary syndrome (PCOS) and is usually characterized by increased total cholesterol, triglycerides, low-density lipoproteins and very low density lipoprotein levels with low high-density lipoprotein. PCOS is associated wth a higher frequency of card Avascular disease because of dyslipidemia. Which are potent markers for cardiovascular risk factors. Metformin, is a widely used antihypenglycemic agent It decreases insulin resistance and reduces hyperglycemia through a reduction of the hepaticglucose production. Objectives Determine Ihe beneficial effect of metformin in PCOS paliente in reducing lipid profile and subsequently reduction incardiovasculardisease. Hctbod Measurements and anaiysis levels of total cholesterol, triglycerides, taw-density lipoproteins, very low density lipoprotein and high-density lipoprotein were samples collected at the Institute of embryo research and infertility treatment. Al-Nahnain Univereity, PCOS patients were recruited at the consultant clinic Patients: forty three women with PCOS were studied. Anthropometric data, Jipki profile, were evaluated, before oral metformffi (50Qmg'twioedaify}treatinent and aflerthree months of use. Patients with PCOS after oral metformin treatment, revealed a sign ificant lowering serum concentrations of totat cholesterol, triglyceride, taw-density lipoproteins and very low density Apoprotein and elevated high- density lipoprotein compared to before treatment. cdqcbttkms dyslipidemia is common finding in PCOS women, in this study we found that the use of oral metformin tablets 500mg/ twioe daily fcrthree months will correct lipid profile level (cholesterol triglyceride, LDL, VLDL and HDL) which is considered as caidiovascular risk factors and this lead to reduce risk of cardiovascular diseases.


Article
Correlation of serum and seminal plasma human growth hormone concentration with semen parameters of normozoospermic and infertile men
علاقة تركيز هرمون النمو البشري في المصل والبلازما المنوية مع معايير المني للرجال سوي النطف والمصابين بالعقم

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Abstract

Background Background: Human growth hormone (HGH) is undisputedly a potent hormone with a wide variety of biological effects. The anabolic actions of human growth hormone have made it attractive as a potential agent forcatabdicproblems in a wide range of clinical conditions, Qbjective I n the present study, we investigated the possible relationship between levels of H G H in serum (S. HGH) and seminal plasma (Sp. HGH) and semen parameters in normozoospermic (NZS) men and infertile patients. materials and methods: In total, 66 infertile patients with azoospermia (AZS; no. 52), asthenozoospermia [AsZS; no, 6) and oligoasthenoteratozoosperrriia (OATZS; no. 8), and normozoospermicmen (NZS; no. 12)were included in this study.. From each subject semen and blood samples were taken to assess seminal plasma and sperm para meters and levels of S. HG H and Sp. HG H; respectively. results The highest 5. HGH was evaluated in AZS patients when compared to NZS and other infertile groups. Significant elevation {P<0.05) in the level of S. HGH was assessed for AZS patents as compared to NZS men. in contrast the level of Sp. HGH in NZS men was significantly elevated (P<0 Q5)when compared to AZS patients only. Positive and significant correlations were noticed between levels of Sp. HGH and semen liquefaction time in NZS, AZS and OATZS groups, in NZS men, positive and significant correlation were observed between Sp. HGH and semen volume and negative and significant correlations were detected between Sp. HGH and percentages of sperm motility, progressive motility, immobility and agglutination. conclusion Our study represents the first study in Iraq showing that the level of HGH in serum and seminal plasma affect male fertility and sperm parameters in normozoaspermic males and infertile patients. Further biochemical and molecular studies are recommended to investigate the mode of action of HGH and its receptors in relation to fertility.


Article
Environmental lead contamination in relation to semen quality
تاثير التلوث البيئي بالرصاص على العقم الذكري

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Abstract

Semen quality is a measure of the ability of semen to accomplish fertilization. Semen quality involves both sperm quantity and quality.The general population is exposed to metals at low concentrations either voluntarily through supplementation or involuntarily through intake of contaminated food and water or contact with contaminated soil, dust, or air. Some metals, such as lead (Pb), are nonessential xenobiotics that can be measured in most of Ihe general population. objective Our goal in this study is to assess relationships between exposure to lead at environmental levels and human semen-quality parameters. materials and methods: The study populatoins consist of 31 infertile male of general population who are occupational^ unexposed to lead and another 26 heal% fertile male as control group Blood lead and seminal plasma lead measurements performed by Ihe electrothermal-atomic absorption spectrometry (AAS) method. Macroscopic and microscopic examination of semen performed according to WHO recommendations. Seminal plasma separated from ihe spermatozoa by centerfugation and stored at -20°C until required for analyses. Results This study showed significant increase in seminal plasma lead mean value in moderate and severe oligozoospermic infertile males than in fertile male controls(p<0,05) The result also showed no statistically significant difference in blood lead concentration among the infertile group compared to fertile controls. conclusoins The results of this study indicate that even moderate exposure to Pb at environmental level [blood Pb < 400 can significantly reduce reproductive capacity in men


Article
Effect of Glycyrrhiza glabra extract on in vitro sperm activation and embiyonic development following intra-peritoneal insemination in mice: experimental model for mammals
تاثير مستخلص عرق السوس على تنشيط النطف والتطور الجنيني بعد التلقيح عبر الغشاء البريتوني في الفئران:موديل تجريبي للبائن

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Abstract

Glycyrrhizaglabm(Gg) is a herbal medicine used in the treatment of different syndromes. Recently, the effect of this plant on the reproductive system has been studied. However, its role in in vitro still not dear. objective The present study aims to investigate the possibility of using Glycyrrhiza glabra extract for in vitro sperm direct activation, and its effect on in vivo fertilization rate (FR) and early embryonic development (ED) following intra-peritoneal insemination (IPI ).The mice were used as an experimental model for mammals. Materials and methods: Glycyrrhiza glabra extract (2 mg/rnl culture medium) was used fix in vitro direct sperm activation technique. The female mice were divided into two groups: spontaneous^ ovulated (SQM) and superovulated groups (SuOM).Each group was divided into two subgroups, the first: the IPI was accomplished by epididymal sperm activated in vitro by adding 20%Gg to ihe culture medium .The second subgroup: the fP! is accomplished without adding Gg to Ihe culture medium. Revue in vitro activation of epididymal sperms with 20% Gg has shown positive effects on sperm concentration, sperm motility, and grade activity of progressive forward movement. There was a significant (P


Article
Evaluation of effect of aqueous and ethanolic extracts of Tribulus terrestris, Phoenix dactylifera and Nasturtium officinale on reproduction in male mice treated with theobromine
تقييم تاثير المستخلص المائي ومستخلص الايثانول للكطب وطلع النخيل وبذور الرشاد على التكاثر في ذكور الفئران المعاملة مع الثيوبرومين

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Abstract

Tribulus terrestris (TT), phoenix dsctifyfera (Pd> and Nasturtium officinale (No) were believed to have fertility-enhancing effects and given by herbalists in Baghdad to men who need to increase their fertility capacity objective To investigate the possibility that aqueous and ethanolic extracts of the plants mixture can counteract the adverse effect Of theobromine on reproductive system of male mic materials and Methods: One hundred and twenty mature male mice were injected intraperitoneally with 250 mg/kg/day of theobromine for four weeks. linen the males were treated intraperitonially with different dose levels of aqueous and ethanolic extracts of a mixture of the three plants for four weeks to evaluate their effects on body weight reproductive organs weight, sperm parameters, hormones level and reproductive performance. results Both extracts showed a significant enhancement in all parameters studied. Almost all these results I showed a dose dependent pattern with the ethanolic extract being the more effective than aqueous extract in all parameters. conclusion Mixture of the three plants seems to counteract the action of theobromine on (he reproductive system of I male mice through enhancing the concentration and motility of spermatozoa, increasing epididymis and seminal vesicles weight which are an indicator of testosterone production which brought about the stimulation of all male reproductive organs.


Article
Developmental changes in fetal male gonads associated with administration of oral contraceptive pills to their mothers during pregnancy.
التغيرات النمائية في المناسل الذكرية الجنينية المرتبطة بتناول الامهات لحبوب منع الحمل الفموية اثناء فترة الحمل

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Abstract

background The effects of taking oral contraceptive pills that contain steroid hormones (estrogen and progesterone) during pregnancy on some aspects of fetus and newborn have been previously reviewed. ojective The objectives of this study are to detect toe effect of using different doses of progestin and estrogen (contraceptive pills OCPs) by pregnant female mice on the gonadal development of their male fetuses, and on their pregnancy outcome. materials and methods: Ninety female mice were divided equally into three major groups: two experimental (Gland G2) and control group according to the level of the dose. Administration of OCPs (either 0.034 or 0.068 mg/kg b. wL /d dissolved with 0.1ml distilled water) orally once a day, were started at (he first day of gestation and continued tilt day 14 for the experimental groups Gland G2 respectively. When the female in each experimental and control groups reach day 17 of gestation, 15 animals of each group were sacrificed, whereas the other 15 animate were left to be sacrificed at birth time. Weight and numbers Of fetuses were recorded, in addition, histological study for their testes were done. results The statistical analysis showed a highly significant (P< 0-01) decrease in weights and numbers of I fetuses {males and females}, and highly significant decrease (P< 0,01) in the testes diameter of fetuses belonged to mothers treated with normal and double dose of OCPs at day 17 and at birth time . in addition* fetuses belongs to G2 mothers revealed testicular undescending to its normal position and remained adjacent to the kidneys at the upper part of the abdominal cavity in comparison with control group. conclusion Administration of steroid hormones orally to pregnant female mice for 14 days causes a highly significant decrease in Ihe weight and number of fetuses at day 17 and at birth time and cause negative effect on the diameter of the fetal testes ."the OCPs can inhibit at its high dose, (he descending of the testes to its normal location al the pelvic cavity and (hen to (he inguinal canal,


Article
Effect of alcoholic extract of Achillea millefolium consumption by pregnant mice on the uterus and reproductive hormones in the female offsprings
تاثير استهلاك الفئران الحوامل للمستخلص الكحولي لنبات القيصوم على رحم والهرمونات التكاثرية للمواليد الاناث

Authors: نسرين خزعل فليح
Pages: 53-56
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Abstract

background Achillea millefolium, (Asteraceae) is flowering plant which is popularly known as yarrow. It has been used in folk medicine to (neat complaints such as inflammation, pain, wounds, hemorrhages and gastrointestinal disturbances. To study the histological changes in uterus and reproductive hormones in female mice delivered to mothers heated with Achillea extract during pregnancy. Material* and methods; Seventy pregnant female mice at age of six weeks were used as a model for this study. The animals were divided into two groups: control (C) (35), and experimental(G){35) groups, The experimental group was given 1.5 mg/kg alcohol extract of Achillea millefolium dissolved in 1ml distilled water orally for the whole pregnancy, while the (C )was given distilled water only in the same amount and for the same period of time. The number and the body weight of the delivered offspring was recorded, in addition (he endometrial thickness, the number and diameter of the uterine glands was measured in the histological sections at puberty In addition evaluation of FSH, LH and E2 hormones levelswere done. The results of this study showed highly significant [pO,G1} decrease in the litter size of the experimental compared to the control group, as well as significant decrease (p<0.05) in the weight of the offspring, the endometrial thickness, the number and diameter of the uteri ne glands in the (G)compared to the (C). conclusion Consumption of low dose Achillea millefolium causes significant decrease in number and weight of the offspring, in addition to its effect on the uterus of the delivered female offspring.

Table of content: volume:1 issue:2