Table of content

Al-Mustansiriyah Journal for Pharmaceutical Sciences

مجلة المستنصرية للعلوم الصيدلانية

ISSN: 18150993
Publisher: Al-Mustansyriah University
Faculty: Pharmacy
Language: English

This journal is Open Access

About

Al-Mustansiriah Journal of Pharmaceutical Sciences (AJPS) publishes original articles in Pharmaceutical, Medical & related sciences including:
Research articles in Pharmacology, Toxicology, Clinical Pharmacy, Medicinal Chemistry, Pharmaceutics, Clinical Laboratory Sciences, and Pharmacognosy. AJPS published twice yearly.

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For more information visit (AJPS) website
http://mjops.com/
E-mail: collegeofpharmacy@uomustansiriyah.edu.iq
P.O. Box: 14070
E-mail: mjops@uomustansiriyah.edu.iq
G-mail: journalcolpharm@gmail.com

Table of content: 2004 volume:1 issue:1

Article
Biochemical study of the effect of typhoid fever and brucellosis infections on some serum salts concentration
دراسة كيميائية حيوية لتأثير التيفوئيد حمى البروسيلا والتهابات في بعض تركيز الأملاح في مصل الدم

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Abstract

Twenty cases of typhoid and brucellosis patients were studied on clinical, serological and biochemical aspects. The mean clinical findings were, most of the ca'ses had sustained fever 66%, gastroenterial symptoms developed as the disease progressed and intestinal hemorrhage 19% as a complications. In serological findings, the number of patients who had +ve positive widal test were thirteen and those who had positive Rose Bengal test were five and those who had positive Widal and Rose Bengal test were two patients. The study was also conducted on ten apparently healthy individual as a control group. The objective ( 1) To study the possible correlation between brucella infection and salmonella typhi infection by biochemical test of some serum salts, and (2) Because of the limited value of Widal's test in the diagnosis of typhoid fever, serum salts of these patients studied to see if can be used as a recommended test to differentiate between these two diseases.The biochemical findings were reveled a significant increase in the level of serum magnesium (P:S;0.004) and a significant decrease in the level of serum potassium (Ps;0.003) in typhoid fever patients. While. patients with brucellosis show moderate increase in the mean value of serum magnesium and sodium (Ps;O. l and Ps;0.08 respectively) and moderate decrease in the mean value of serum potassium (P:S;0.08). While patients with typhoid and brucellosis (combination) show significant increase in the mean value of serum magnesium and sodium (Ps;0.00 I and Ps;0.001 respectively) while there is increased in the level of serum total calcium (Ps;O. l) in patient with typhoid fever only. While serum ionized calcium show significant increase in the mean value in patients with typhoid fever and brucellosis (Ps;0.06). The changes in these biochemical parameters were well discussed .

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Article
Evaluation of gingival immunoglobuline G . level in gingival blood from health to gingivitis

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Abstract

As the immunoglobulin G. play a central role during the immunologic process of the gingival inflammation ,the evolution of its quantity from health condition to gingivitis and visa-versa , seemed to be essential to have a Clear pict4re about its importance .The immunonephelometer-laser ,able to quantify the amount of immune cJmplex , when a specific antibody anti IgG is used to form a measurable immune complex in vitr . Sampling the gingival blood in health, diseased, then reversed to health conditions gave a suggesti g result that the IgG amount progress in faible significant positive correlation with the degree of gingi al inflammation, the conclusion suggest that the gingival blood could give,a close

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Article
The effect of some excipients on the formulation of norfloxacin 4001ng tablets

Authors: Al-Khalidi S. Siham
Pages: 14-25
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Abstract

Norfloxacin a synthetic, broad-spectrum quinolone carboxylic acid derivative, active against Gram negative & Gram-positive bacteria. Used clinically in the treatment of acute and chronic urinary tract infections, cystitis •urethritis, pyelonephritis, prostatitis& gastroenteritis . This study is concerned with the formulation of 400mg Norfloxacin coated tablets with 710mg weight, 12mm in diameter, less than I Ominutes disintegration time, & less than I % friability. Many trials were made to prepare a satisfactory tablet formula for the drug by using wet-granulation method with various additives. It was found that Polyvinylpyrrolidone as a binder gives the most satisfactory tablets. The effect of disintegrants on drug release was also investigated on the selected formulas. Conventional corn starch, sodium starch glycolate and microcrystalline cellulose were tried as disintegrants. It was found that cross-caramellose (carboxymethylcellulose) was the best disintegrants. A comparative study on the physical properties of the prepared tablets with Noroxacine ( Razi labs,Aleppo.Syria ) , Neolloxacin ( the Alexandria. Egypt ), and Norfloxacin showed that the release of the drug from the selected formula was similar to that obtained from Alexandria. The stability of the prepared tablets was studied at 25°C, 40°C, 50°C, &70°C and the expiration date was calculated and found to be equal to 7 .3 years, 4.7 years, and 2.4 years & four months respectively. Key word: Norfloxacin­Pharmacokinetics.Fluoroquinolone- Norfloxacin formulation. * Ministry of Industry , lbn - Sina Research centre .

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Article
Clinical and biochemical comparative study between alternate and every day clofibrate - lovastatin combination therapy on mixed hyperlipidaemia

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Abstract

Mixed hyperlipidaemia is the most common form of hyperlipidaemias,wherc the patients have an elevation in both triglycerides and cholesterol levels with a high risk of atherosclerosis and chronic hea,t diseases. The therapeutic approach for this disorder described a range from nonpharmacologic lifestyle modifications to newly introduced pharmacologic options.Depending on the basis of recent reports involve fibrate - statin combination and associated with increase the incidence of side effects (myopathy, hepatotoxicity) and therapeutic cost, we suggest and investigate in our study a clinical trial for management of this metabolic disorder by using clofibrate and lovastatin on alternate days instead of the standard daily combination of the same drugs. The study compares the safety, efficacy and cost of both therapeutic regimens for three months follow - up period. A total of 44 patients with a known mixed hyperlipidaemia were enrolled in this study. Of the 40 patients who completed the study, 20 (10 males, 10 females) received alternate - day therapy (group I), their age and weight ranges were (40-65) years and (62-85) Kg, respectively. The remaining 20 (IO males, 10 females) received every day therapy (group II), their age and weight ranges were ( 42-67) years and (65-89) Kg, respectively. Ten healthy age - matched control subjects (5 males , 5 females). The biochemical investigations involve measuring total serum cholesterol, triglyceride, LDL and HDL cholesterol levels as parameters of lipid - lowering agent efficacy; while SGOT,SGPT and CK levels as parameters of safety. All of these parameters were determined at baseline (day 0) and after three months of treatment for both therapeutic groups. The study revealed that there was no significant difference between both treatment groups regarding the percent changes in lipid profiles from baseline values. These profiles had been returned to normal limits in all patients in both groups. The mean of SGOT levels for both treatment groups was significantly higher than that of control, but with group II the extent was more, while for SGPT levels group II only was significantly higher (less safety) than control one. With respect to CK levels and for both treatment groups, only slight elevation (not significant) occurred compared with control, but with group II the extent was more.With group I, the therapeutic cost was reduced by nearly 50% compared with group-II. By this clinical and biochemical trial, we decreased the side effects and cost of fibrate - statin combination while keeping their efficacy in lowering serum lipids.

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Article
Proportion of hepatitis C virus antibodies in icteric patients

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Abstract

A total of 1783 sera from icteric patients (988 male & 795 female), their ages ranged 8-54 years, were tested for the presence of viral hepatitis markers (hepatitis A, B, and C), using the available diagnostic kits (enzyme linked immunosorbant assay). 300 donor sera were also tested as matched control. Among the icteric patients 859 (48,2%) had evidence of acute hepatitis A (HA), 499 (28%) were found to be infected with hepatitis B (HB), and hepatitis C virus (HCV-Ab) was detected in 8.2% of patients that confimed by recombinant immunoblot assay. The results indicated that the maximum HCV seroprevalence was found in patients more than 30 years old, and there was no difference in the chance of infection in both sexes. The main route of HCV transmission was observed in icteric patients who had received blood, and those underwent surgical intervention. These reflect the fact that some of transfused blood may contain HCV that could not be detected by routine serological tests used in Blood Bank. There is a need to identify HCV carriers and the increased awareness of medical and paramedical personnel regarding the risk of transmitting the disease iatrogenically. Furthermore the need to document the risk of nosocomial transmission and highlight the crucial role of molecular sequence based phylogenetic analysis of cloned viral isolates in the investigation of HCV infection.

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Article
Biocemical studies of alkaline phosphatase for cancer patients

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Abstract

The activity of alkaline phosphates (ALP) was determined by the calorimetric method of kin and Armstrong in serum of 3 03 cancer patients and 42 normal healthy controls. The ANOV A test of type, age sex and stage of disease ,the results showed that the ALP activity was higher in cancer patients then normal (p=0.000),this incensement could be used as a tumor marker (significant difference p=o.ooo) detected bone & liver cancer and to detect metastases to the organ. The enzyme activity reached its highest level in the stage group (40-50 years). The results also show that there are no significant differences of ALP activity between males and females while the activity was increased with the development of disease stage. Regan isoenzyme (RI) of ALP was elevated in about I 0%-20% of cancer patients and was higher in pancreas ,cervix ,ovarian than stomach ,lung and breast .

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Article
Recurrent urinary tract infections in men. A role for aberrant bacterial forms

Authors: Al–Araji K. Muhammed
Pages: 48-52
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Abstract

We studied 45 infected a symptomatic men who had experienced recurrent urinary tract infections classified as bacterial relapse. These patients did not have ilial loop bladder, urethral catheters, suprupubic catheters or condom drainage. We had to process more than 1000 urines from patients attending the neurosurgery clinic at Hamad Shihab Hospital from March 2000 to July 2000 to identify the 45 study patients. A positive antibody coated bacteria influences test was detected on the urinary sediment of each of these patients. This selected study group was subjected to excretory urography and a 2–weeks course of antibiotic in accordance with the results of in vitro susceptibility tests. Eight patients experienced a cure. Recurrences developed in 32 patients (24 relapses, 8 reinfections). And in 4 patients a super infection emerged. No pathogenic role could be attributed to aberrant bacterial forms in this patient's population of symptomatic patients with recurrent invasive urinary tract infection.تم دراسة 45 حالة مريض مصابين كحالةة رريةية لالة ين ينةكلن مةن تكةرار ابصةابة بتلتلابةاي الموةار البلليةة كحالةة تكاسةية بابصابة البكتيرية. كل هلبء المريى لةم يةتم سةتمدام الممةرن اب بةلبف لغتأريةي ل يةة مةادد مةرى تةدمل الةى المخا ةة ال سةتمدام تمةريا ابدرار لوم ة اةف حااةةة ماصةة لة لك الغةرض . حية تةم احة 1000 مةل ن لةردرار للةلبء المريةى الة ين كةةا لا يراو لن ن بة الوراحة اف مستنأى حماد نلاب ال سكر بين ار 2000 الى لاية تملز 2000 لبول مطابقةة لتقيةيم ا لدراسةة تم وراء الأح الملوب لغمستيد المغغف لغورخلمة الحامغة ل من مرل لولدها اف ترسب ابدرار . مةن مةرل هة ل المرحغةة تةم متيةار موملرةة مةن المريةى بوةراء احلصةاي نة ارية لغولةاز البةللف للمتاب ةة التأريةي ابدرار لغولةاز البةللف ب ةد الم الوةة بمياداي الحياد لالتف تم متيارها لاق سغلب الدلاء المأيل ب د وةراء احة الحساسةية لغةدلاء رغةى تغةك الوةراخيم المسةببة لتغةك ابلتلاباي لم لا تبين ن تس ة مريى قةد نةألا نةأاءا تامةا مةا البقيةة لهةف 36 ( حالةة مريةية تةم مرحةةة ن 24 مة لم قةد رةاد ابلتلاب للم خا ية ب د تغك الم الوة لخما ية م لم تم صابتلم خا ية لمة لم رب ةة ريةدي ابصةابة للوةلد تغةك الوةراخيم يةمن كريةاي الدم البيياء . بتلود حقيقة مريية ت سب لغورخلمة النا د لالملولدد لدى المريى لكةل لم مريةى رريةيلن مةا رةادد حتةراق لالتلاب الولاز البللف..

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Article
Effects of adding digitoxigenin and gitoxigenin to the nutrient medium on cardiac glycosides production from digitalis purpurea (Var. Excelsior Mixed) by using tissue culture technique

Authors: AL–Khateeb H. Ekbal --- Awad J. Zeinab
Pages: 53-60
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Abstract

The present study was performed using tissue culture technique purpose of knowing the effect of using precursors in the presence of TDZ semi–cytokinin and maltos sugar on the cardiac glycosides constituents shoots of Digitalis purpurea digitoxin, gitoxin and digoxin, in this study , shoot tips were taken from seedlings of Digitalis purpurea ( var . Excelsior Mixed ) with 1 cm lenth , then they were cultured on nutrient medium adding with two kind of precursorres digitoxigenin (Dg) and gitoxigenin (Gg) with the concentrations 0.0, 0.1, 0.5, 1.0 and 2.0 mg/L for each one, as well as adding for all the treatments ,the TDZ with the 0.5 mg/L concentration and the maltose sugar with the 30 gm/L concentration for induction the multiplication shoot tips processe . The results showed that this study and after 45 day of starting the culture, the treatment which contained digitoxigenin precursors in the concentration 0.5 mg/L was the best compared of the other treatment in respect to the characteristics studied.In this treatment, the multiplication shoots have given sum dry with the amount weight of 6.52 gm containing gitoxin, ditoxin, digoxin with the amount of 382.48, 192.18 and 203.58 g/gm dry weight respectively, beoide the inceased amount of dry weight and cardiac glycosides , other characteristics component of the shoots was increased as the containing of total chlorophyll and percent ratio of soluted sugar and starch in the amount 4.81 mg/g fresh weight, 5.59% and 8.56% respectively. Abbreviations :- Dg (Digitoxigenin); Gg (Gitoxigenin); MS (Murashige and Skoog Medium); TDZ (Thidiazuron); Mg (Milligram);g (Microgram); L (Litter); gm (gram). اجريت هذه الدراسة في مجال زراعة الانسجة ، وذلك لغرض معرفة تاثير استخدام اثنين من البوادئ وبوجود مادة شبيه السايتوكاينين TDAوسكر المالتوز على محتوى الافرع المتضاعفة لنبات Digitalis purpurea L من الكلايكوسيدات القلبية Digoxin , Gitoxin , Digitoxin ، حيث تم اضافة البادئين Digitoxigenin ، Gitoxigenin الى الوسط الغذائي MS وبالتراكيز (2.0, 1.0, 0.5, 0.1, 0.0) ملغم/لتر ولكل منهما على حدة ، ايضا اضيف الى الوسط الغذائي ولكافة المعاملات مادة TDZ بالتركيز 0.5 ملغم/لتر وسكر المالتوز بالتركيز 30 غم/لتر ، اظهرت نتائج هذه الدراسة وبعد 45 يوما من بدء الزراعة بان المعاملة المحتوية على البادىء Digitoxigenin وبتركيز 0.5 ملغم /لتر هي الافضل مقارنة ببقية المعاملات من حيث الصفات التي درست ، حيث اعطت الافرع المتضاعفة في هذه المعاملة حاصلا جافا بلغ 6.52 غم محتويا على Digitoxin ، Gitoxin ، Digoxinبمقدار بلغ (203.58, 192.18, 382.48) مايكروغم/غم وزن جاف وعلى التوالي ، كما اعطت هذه المعاملة اعلى القيم بالصفات الاخرى التي درست وهي محتوى الافرع المتضاعفة من الكلورفيل الكلي ،النسبة المئوية للسكريات الذائبة والنشا وبلغت (4.18 ملغم/غم وزن طري ،5.59% ،8.56% ) وعلى التوالي . الرموز المستخدمة:- Dg (Digitoxigenin) ; Gg ; (Gitoxigenin) MS (Murashige and Skook Medium ) ; TDZ (Thidiazuron) ; Milligram) Mg ) ; (Microgram) mg ; (Litter) L ; (gram) gm .

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Article
Binding of 99mTc to human serum albumin

Authors: Abdulrahman K. Loay
Pages: 61-68
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The specificity of 99m Tc-MDP binding to HSA was examined , the results showed that the non specific binding was 21-23% of the total binding . The range of optimum pH for the binding was 7.4-7.6 . The most suitable amounts for HSA to give maximum binding was (70g)per incubation medium , binding seemed to be affected by 99m Tc- MDP concentration and also mono and divalent metal chloride salts. The association constants (ka) and maximum binding capacity (Bmax) of 99m Tc-MDP binding to its binding sites of HSA was determined from scatchard and double reciprocal plots , the results revealed that (ka) and (Bmax) values were temperature dependant.تم اختبار الارتباط الانتقائي لمركب 99m Tc-MDP المرتبط مع ألبومين مصل الدم البشري وأوضحت النتائج بان الارتباط غير الانتقائي كانت بحدود 21-23 % من الارتباط الكلي . إن مستوى الأس الهيدروجيني الامثل لهذا الارتباط هو 7.4- 7.6 . وان التركيز الامثل لألبومين مصل الدم ليعطي أعلى ارتباط هو ( 70 ) مكر وغرام . أوضحت النتائج إن الارتباط الامثل يتأثر بتركيز المعقد 99m Tc-MDP و تركيز كل من أملاح الكلور للفلزات الأحادية والثنائية التكافؤ . إن قيمة ثابت الارتباط والارتباط الأعظم للمعقد 99mTc-MDP المرتبط في مواقع الارتباط الانتقائية لألبومين مصل الدم تم حسابه من علاقات سكاجارد scatchard and double reciprocal وأتضح من النتائج إن هذه القيم تتأثر بتغيرات درجة الحرارة .

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Article
Yersina enterocolitica in adults with gastrointestinal disturbances need for cold enrichment

Authors: Al–Araji K. Muhammed
Pages: 69-71
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In a survey of hospitalized adult, cold environment of feces resulted in an incidence rate of Yersina enterocolitica equal of Salmonella species, Yersina enterocolitica was not recovered by routine procedures.خلال مسح للمرضى الكبار المتواجدين في المستشفى . تم أستخدام بيئة باردة للبراز حيث كانت النتيجة وجود نسبة من جرثومة البارسينيا أنتيروكوليتكا تساوي جرثومةأصناف السالمونيلا حيث تبين ليس من السهل التعرف عليها وتشخيصها عند أستخدام الطرق المختبرية الروتينية الاعتيادية للتشخيص الجرثومي .

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Article
Leptin: A new aspect of a multifunctional protein

Authors: El-Yassin D. Hedef
Pages: 72-85
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The Maintenance of an appropriate body weight is very important for the survival of higher organisms. In order to have a constant weight, there must be an energy balance. Despite short-term mismatches in energy balance, energy intake can generally be matched to energy expenditure with great precision due to the existence of several types of signaling biomolecules such as leptin. Leptin is an adiposity-derived hormone that decreases food intake and body weight via its receptor in the hypothalamus. In rodents, it also modulate glucose metabolism by increasing insulin sensitivity. Leptin interacts with pathways in central nervous system and through direct peripheral mechanisms. Leptin appears to have a range of roles as a growth factor in a range of cell types. Surely, more interactions are yet to be discovered. Although the complexity of leptin axis indicates that it is difficult to derive effective treatments for obesity, leptin was the first of a group of adiposite-secreted hormones to be used clinically to treat hypoleptinemic status. This review sheds a small ray of light on the wide landscape of function, roles, actions and interactions of leptin to improve knowledge and point the way to the underlying physiology which predisposes some individuals to apparently unregulated weight gain

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Table of content: volume:1 issue:1