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The effect of sulcular injection of meloxicom on biochemical parameter of rabbit

Authors: Hashim D. Musa هاشم موسى --- Lekaa M. Ibrahim لقاء ابراهيم
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 4 Pages: 88-91
Publisher: Baghdad University جامعة بغداد


Background: Meloxicam is an NSAID of the oxicam class that acts by inhibiting prostaglandin synthesis and inducibleCOX-2, thereby exerting anti-inflammatory effect. This study aimed to evaluate the level of alkaline phosphetase andhigh sensitivity C - reactive protein as response to sulcular injection of meloxicom using a rabbit model.Material and method: Forty five male rabbits of the same species were divided into three groups. Group 1 whichincluded 20 rabbits that injected with meloxicon in a dose equal to the human therapeutic dose /kg .Group 2 whichincluded 15 rabbits that injected with normal saline. Group 3 which included 10 rabbits used as control group. Five mlof blood was collected from the rabbits ear vien for biochemical analysis at deferent time interval. Biochemicalanalysis included alkaline phosphetase (ALP) which analyzed by using Biolabo kit and High sensitivity C- reactiveprotein (hs- CRP) was measured using ELISA technique.Results: The result showed that the level of ALP after 1 day of sulcular injection in group 1 was 101.25 then it wasdecrease to 97.50 after 14 days while mean of ALP in group 2 was 70.33 After 1 day of injection and reach to 74.67After 14 days and this almost near to the mean value of control groupStatistic description of hs-CRP for group 1 was decreased. The mean value from 11.617 after 1 day to 3.639 after 14days. For group 2 also there was decreased in the mean from 11.556 after 1 day to 3.536 after 14 days, while for thecontrol group the mean value was 3.170 .Conclusions: The sulcular injection of NSAIDs seems to be of particular interest. This may help to further reduceadverse systemic effects of NSAIDs in treatment of periodontal disease safely.

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