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Study of some immunological parameter to vitiligo disease in Al-Hussein hospital in karbalaa province
دراسة لبعض المعايير المناعية لمرضى البهاق في مستشفى الحسين (ع) في محافظة كربلاء المقدسة

Authors: علياء عزيز جبير الموسوي --- هيام عبد الرضا كريم العواد --- علي حمود السعدي --- احسان خضير الطالقاني
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2017 Volume: 15 Issue: 2 Pages: 122-129
Publisher: Kerbala University جامعة كربلاء

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Abstract

This study aimed to shed light on vitiligo and conducting genetic immunological examination and knowledge of the change in the levels of certain cytokines (IL-2 and TNF-α) and certain hormones and certain genes different genetic ways in people with vitiligo, as well as knowledge of the relationship between those standards and the extent of vulnerability of those genes under study, and the current study included 50 people from vitiligo patients, as well as 50 people (apparently healthy) as the control group for the study, as were collected those samples from the Husseini Teaching Hospital in the city of Karbala (unit skin counseling) during the time period from 1/5/2015 until 1/12/2015. Were examined sera of all patients to estimate the standard levels of immune IL-2, TNF-α using ELISA enzyme linked immunosorbent assays (ELISA), the results showed the following:There were influence of gender on the immune parameters under study here statistical analysis dealt with the study of male patients with compared with the male control group as it appeared that TNF-α may be significantly increased in patients compared with a healthy except IL-2, which fell when the male vitiligo patients compared with the control, also conducted a study a comparison between the female vitiligo patients and the female control group as the comparison showed a significant rise in all immunological criteria results at the level of probability (P <0.05) for females vitiligo patients when compared between the same standard rates of female control group.The research study showed the effect of smoking and passive role on the vitiligo patient samples were divided between smokers and non-smokers, as the value of SOD-1 rose and TNF-α are significant in smokers patients compared with the control group, while IL-2 rate saw a significant decrease in the levels compared with a group control. Emerged search results the importance of family history, through the emergence of significant differences between patients who have a family history of the disease and who do not have family history results showed high immunological criteria levels of hormones under study in the sera of people with vitiligo who have the same disease among family members of casualties compared to patients who do not have emergence of this disease. The results also show a decline in immune parameters levels in patients who have a kinship between the parents compared to patients who do not have kinship between parents has been the declining moral at the level of probability (P <0.05), also addressed the impact of social status on immunological parameters in serum as observed high averages of those standards among married than non-married couples has also been a comparison between the patient group and control depending on the social situation was observed that there were differences between those standards among married patients and between couples of control as patients rates rose significantly, as is the case with unmarried of patients compared with non-married couples of the control group. The duration of the disease after divided into categories depending on the months TNF- recorded the highest rate among the group of the month (240-161), and finally dropped the category of (80-1) a month , also recorded increases in results averages IL-2 with the injury categories (300-241) a month, while the rest fell aggregates.

هدفت هذه الدراسة لتسليط الضوء على مرض البهاق واجراء دراسة مناعية وراثية ومعرفة التغير في مستويات بعض المتغيرات المناعية وبعض الهرمونات وبعض الجينات بطرق وراثية مختلفة لدى المصابين بمرض البهاق وكذلك معرفة العلاقة بين تلك المعايير ومدى تاثرها بتلك الجينات قيد الدراسة ، وقد تضمنت الدراسة الحالية 50 شخصا من مرضى البهاق ، فضلا عن 50 شخصا (أصحاء ظاهريا) بوصفهم مجموعة سيطرة للدراسة إذ تم جمع تلك العينات من مستشفى الحسيني التعليمي في محافظة كربلاء (وحدة الاستشارة الجلدية) خلال الفترة الزمنية من 1/5/2015 ولغاية 1/12/2015. تم فحص أمصال جميع المرضى لتقدير مستويات المعايير المناعية IL-2,TNF-α باستخدام تقنية اليزا(فحص للمقايسة المناعية المرتبطة بالانزيم) enzyme linked immunosorbent assays (ELISA) وقد بينت النتائج ان تأثير لنوع الجنس على المعايير المناعية قيد الدراسة وهنا تناولت التحاليل الاحصائية دراسة ذكور المرضى مع مقارنتها مع ذكور مجموعة السيطرة اذ ظهر أن TNF-α قد ارتفع بشكل معنوي لدى المرضى مقارنة مع مجموعة الاصحاء اما IL-2 الذي انخفض عند ذكور مرضى البهاق مقارنة مع السيطرة، كما اجرت الدراسة مقارنة بين اناث مرضى البهاق وبين اناث مجموعة السيطرة اذ اظهرت نتائج المقارنة ارتفاع معنوي في كافة المعايير المناعية عند مستوى احتمالية (P<0.05) لاناث مرضى البهاق عند مقارنة بين معدلات نفس المعايير لاناث مجموعة السيطرة .

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