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Article
Brucellosis as trigger for autoimmune hepatitis in susceptible individual

Author: Eman Sh. Al-Obeidy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 4 Pages: 467-469
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Autoimmune hepatitis (AIH) is a rare chronic liver disease of unknown etiology, characterized by hypergammaglobulinemia, characteristic autoantibodies, and a favorable response to immunosuppressive treatment. Strong circumstantial evidences denoted that there is quite long list of environmental factors such as (food additives and drugs), viruses and toxins which play an important role in precipitating this disease. Brucellosis is endemic in Iraq. It may involve any organ in the body. Liver is frequently involved. Doxycycline used for treatment occasionally may lead to hepatotoxicity. Objective: the aim of the study is To show the relationship between brucellosis , AIH, and hepatotoxicity of doxycycline . Methods: the study was performed on 2 Iraqi patients with brucellosis, attending the teaching hospital for gastroenterology and liver disease in the period between November 2003 and July 2004. Brucella were studied by Rose Bengal test and confirmed by indirect immuno florescence assay (IIF). Results: anti-SLA/LP Abs was detected in 2 patients with brucellosis. Conclusion: brucellosis or doxycycline is a trigger of AIH

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Article
Is Chlamydia Pneumonia An Independent Risk Factor In Ischemic Heart Disease

Authors: Eman Sh. AL-Obeidy --- Eman Sh. AL-Obeidy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 2 Pages: 151-154
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Immune system may interplay between Chlamydia pneumoniae infection and ischemic heart disease (IHD).Major histocompatibility genes regulate innate and adaptive immunity..OBJECTIVE:This study was established to shed light on the possible association between ischemic heart disease (IHD) with Chlamydia pneumoniae infection and HLA antigens.PATIENTS AND METHODS:Microlymphocytotoxicity assay has been applied for HLA-typing of 150 blood samples of 100 IHD patients and 50 healthy normal controls, In addition enzyme linked immunosorbant assay (ELISA) used to detedct C pnuminiae IgA and IgG.RESULTS:An increased frequency of HLA-A*2, B*35 alleland HLA-A*2-B*35 haplotype was observed for patients group versus control group with P-value (0.0001, 0.05, and 0.001) respectively.CONCLUSION:This finding demonstrated that the HLA-B*35 positive haplotypes confer the C.pneumoniae-related risk for IHD. HLA-DR3,DR4 and DR7 might play a role in AIH susceptibility


Article
Association of Fibrinogen as a Myocardial Infraction Risk Factor in Men

Authors: Basil. N. Saeed --- Eman Sh. AL-Obeidy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 4 Pages: 392-394
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Acute myocardial infarction (AMI) is an irreversible myocardial injury and necrosis caused by serious and long term ischemia. Fibrinogen is considered as
one of the probable risk factors of myocardial infarction.
Patients and methods: 1.8-mL venous blood specimen from 40 patients with MI and 50 control subjects was obtained and put it into tubes containing 0.2 mol/L trisodium citrate. Plasma fibrinogen level was determined by the method of Clauss (Diagnostic Stago, France). Results The mean age of patients was (45.2 ± 6) years in patients with premature myocardial infarction and (45.06±5) years in the control group (p =0.07). There were no statistically significant relationships between the two groups in history of premature myocardial infarction in their first-degree relatives (p =&#61472;0.05), cigarette smoking (p =&#61472;0.06), diabetes (p =&#61472;0.08), or hypertension (p =&#61472;0.071). The mean plasma fibrinogen in patients (495 ±10.2mg/dL) was elevated markedly compared with the control group (465±8.4 mg/dl) ( p =&#61472;0.01) . Hyperfibrinogenemia (>450 mg/dL) was detected in 87.5% of patients and 52.0% of controls. Conclusion: This study introduced fibrinogen as a risk factor for premature coronary artery disease in Iraqi men


Article
The Role of IL-1 and Tumor Necrosis Factor-α in Pathogenesis of Rheumatoid Arthritis

Authors: Eman Sh.Al-Obeidy --- Shatha F. Abdullah
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 2 Pages: 161-165
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Rheumatoid Arthritis (RA) is a common chronic inflammatory and destructive arthropathy that cannot be cured.Interlukin-1 (IL-1), IL-6 and tumor necrosis factor (TNF- α) are the key cytokines that drive inflammation in the disease.OBJECTIVE:The study was established to shed light on the possible role of IL-1 and TNF- α in pathogenesis of RA.PATIENTS AND METHODS:Rheumatoid Factors (RF),TNF-α and IL-1 were detected by Enzyme-Linked Immunosorbent Assay (ELISA) .C-reactive protein(CRP) on the other hand has been detected by using latex agglutination kit in the serum of 50 Iraqi patients with RA in comparison with 50 healthy individuals.RESULTS:Significant high levels of IL-1and TNF- α were observed in RA patients sera with P-value ( 0.04 and 0.001) respectively compared to healthy control group, in addition a positive linear association was found between the concentration of IL-1and TNF- α and CRP with P-value ( 0.05 and 0.001) respectively.CONCLUSION:IL-1and TNF- α play a role in pathogenesis of RA


Article
Autoimmune hepatitis:- Another specific immune marker

Author: Eman sh. Al- obeidy, ايمان شاكر العبيدي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 1 Pages: 61-63
Publisher: Baghdad University جامعة بغداد

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Article
frequency and significance of antibodies to asialoglycoprotein receptor in patients with autoimmune hepatitis

Author: Eman Sh. AL-Obeidy ايمان شاكر العبيدي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 1 Pages: 89-92
Publisher: Baghdad University جامعة بغداد

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Article
brucellosis as trigger for autoimmune hepatitis in susceptible individual

Author: Eman Sh. AL-Obeidy ايمان شاكر العبيدي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 3 Pages: 357-358
Publisher: Baghdad University جامعة بغداد

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Article
H. Pylori Infection in Iraqi patients with ischemic heart diseases

Authors: Basil. N. Saeed ايمان العبيدي --- Eman Sh. AL-Obeidy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2011 Volume: 53 Issue: 1 Pages: 29-31
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Cardiovascular diseases are among the most common cause of death in Developed countries. In addition to traditional risk factors for cardiovascular disease, nowadays, accumulating evidence indicates that a variety of infectious agents may contribute to pathogenesis of ischemic heart disease.Patients and methods: 125 patients (25 females and 100 males) attending the department of cardiology, Baghdad, teaching hospital over the period December 2008- June 2009were enrolled. Their age range between (39-75 years) compared with 50 healthy individuation (Age & sex matched).The sera were tested for H. pylori antibodies using enzyme linked immunosorbent assay (ELISA).Results: 80% of patients showed the anti-H. Pylori IgGs (P < 0.05). But there were no significant association between risk factors & H. pylori infection (P > 0.05).Conclusions: These findings raise the possibility that exposure to H. pylori may lead to increased risk of coronary artery disease independent of other risk factors.Keywords: coronary artery disease, Helicobacter pylori, RAO


Article
Evaluation of T- Helper (Th-1) Cytokines during the Treatment Responses of chronic Hepatitis C Virus

Authors: Eman Sh. AL- Obeidy --- Khalid A. Al-Khazraji
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 4 Pages: 464-466
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:It is widely assumed that cellular immune response and cytokine (especially proinflammatory cytokines) production play an important role in the course and treatment effectiveness of chronic hepatitis C infection.
Aim of the study: evaluate the level of Th-1 cytokines during treatment of chronic HCV infection and their dynamic changes in response to treatment.
Patients and methods: The study was performed on sixty patients with chronic HCV infection, the patients were recruited from medical city gastroenterology and hepatology teaching hospital for the period from February 2007 till February 2008 and 50 healthy control group. Diagnosis was made using third generation ELISA-based screening test, RIBA-based test and PCR-based test. On the other hand, Cytokines (serum level) were determined by ELISA method before, during (6, 12, 24 weeks) and after the treatment.
Results: This study showed that after 6 weeks from the initiation of the treatment by pegilated interferon-α in the combination with ribavirin, concentration of serum cytokines IL-1β, TNF- α and INF- γ have significantly changed and at the end of the treatment concentration of all cytokines have decreased and this change was statistically significant for all cytokines.Conclusion: dynamic changes of some cytokines during INF- α and ribavirin treatment may be used as a predictor factor for evaluation of the therapy effectiveness.


Article
HLA prevalence in Iraqi patients with ischemic heart disease

Authors: Eman Sh. AL-Obeidy --- Basil N. AL-Dileamy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 2 Pages: 182-184
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The etiology of ischemic heart disease (IHD) is believed to have an immunological component. Association with human leukocyte antigens (HLAs) has been previously reported, particularly with DR6.Patients and methods: 75 cardiac patients were admitted to the coronary care unit, Baghdad Teaching Hospital over the period October 2008-May 2009 with the clinical diagnosis of acute coronary syndrome and STEMI myocardial infarction their ages range was (25-82) years the number of male was (55) (73.3%) and female was (20) (26.7%). All cases have routine ECG, cardiac marker’s measurements, routine haematological, Biochemical test and 2mls of blood reserved for HLA study.
Results: It was found that HLA-DR1 (8%) (P 0.001) has significant risk factor in the development of ischemic heart disease while HLA B (62%) (P 0.0009) has a protection factor in ischemic heart disease.
Conclusions: Our result suggests that strong relation between the incidence of acute ischemic episode (acute coronary syndrome and STEMS myocardial infarction and HLA-DR1) which mean that there may be predisposing genetic factor for the development ischemic heart disease.

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