research centers

Search results: Found 1

Listing 1 - 1 of 1
Sort by

Evaluation of the effect of local exogenous application of osteopontin on wound healing in rats

Authors: Zahraa Raheem Al-Zamely زهراء رحيم الزاملي --- Enas Fadhil Kadhim ايناس فاضل كاظم
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2018 Volume: 30 Issue: 2 Pages: 23-28
Publisher: Baghdad University جامعة بغداد


Background: Wound healing is a complex dynamical interaction between various cell types, the extracellular matrix, cytokines, and growth factors. osteoponetin is a substance that acts as an anti-inflammatory.Aims of study: The study was designed to identify the role of local exogenous applications of osteopontin on wound healing (in cheek skin).Materials and methods: Thirty adult male albino rats weighting an average of (250-300gm) used in this study, incisional wounds were made in the skin of the cheek of rat and they were divided into the following groups:A-Control group: 15 rats treated with 1μ l of normal salineB-Experimental groups: 15 rats treated with topical application of 1μl osteopontin.The scarification of animals were done for the healing intervals (1, 5 and 10 days) Histological analysis and assessment of number of inflammatory cell, Thickness and contraction of incision were performed for both experimental and control groups for all healing periods.Results: Histological analysis revealed that osteopontin accelerate wound healing of cheek skin and there was highly significant difference among studied groups in periods 1,5,10 days. Regarding mean values of epithelial thickness, inflammatory cell count and contraction of wound area have reported a highest value different in 1, 5 and 10 days durations.Conclusion: It can be concluded that application of osteopontin shown efficacy in the healing of skin wounds induced in rats

Listing 1 - 1 of 1
Sort by
Narrow your search

Resource type

article (1)


English (1)

From To Submit

2018 (1)