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The effect of some antifungal agents and chlorhexidine on Candida albicans adherence on acrylic resin denture base surface (In vitro study)

Authors: Nagham H Kassab --- Ghada Y Abdul–Rahman --- Tariq Y Kassab–Bashi
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2004 Volume: 4 Issue: 1 Pages: 65-72
Publisher: Mosul University جامعة الموصل


The adherence of Candida albicans on acrylic resin denture base surface is considered as the first step in the pathogenicity of candida–associated denture stomatitis which is the most prevalent form of oral candidiasis in denture wearers. This study was an in vitro study aimed to evaluate the anifungal effect of fluconazole, nystatin and chlorhexidine and their antiadherent effect on Candida albicans cells that attached on the fitting surface of denture base. It was determined, using broth microdilution method at two concentrations for each drug, and the results were determined using spectrophotometer. All drugs had a highly significant antifungal effect on Candida albicans isolate at their two concentrations. The effect of saliva on the adherence of Candida albicans on the fitting surface of denture base was also considered. This study concluded the importance of saliva in increasing the microbial adherence; i.e., the mean number of adherent cells on acrylic resin samples in the absence of saliva was 7.4 + 1.9 cell/mm2 and with the presence of saliva the number was 29.1 + 2.7 cells/mm2. The number of remaining adherent cells was counted using fluortescent microscope. The mean number of remaining cells which adhered on acrylic resin samples after the immersion in first concentration fluconazole, nystatin and chlor-hexidine for one hour respectively were 4, 5 and 2.6 cells/mm2 and for the second concentration/1 hour the numbers were 3.2, 4.1 and 1.7 cells/mm2 compared to the normal number of adherent cell 29.1 + 2.7 at p<0.01.

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