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Maternal–Placental Growth Factor and the Identification of Fetuses with Placental Intrauterine Growth Restriction

Authors: Henan Dh Skheel Al Jebory --- Asmaa Zubaid Alazzawy
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2018 Volume: 17 Issue: 1 Pages: 36-41
Publisher: Al-Mustansyriah University الجامعة المستنصرية


Objective: This study was designed to discriminate between fetal growth restriction that is placentally mediated and constitutionally smallfetuses depending on the measurement of placental growth factor (PlGF) in the maternal circulation. Study Design: This was a prospectivecase–control study. Settings: This study was conducted at the Department of Gynecology and Obstetrics at Al‑Yarmouk Teaching Hospital.Patients and Methods: The study included 100 cases (11 placental intrauterine growth restriction [IUGR] and 89 constitutionally small)with singleton pregnancies. Serum PlGF was measured by ELISA technique. Concentration less than the 5th percentile for normal pregnancywas considered a positive PlGF test. Results: A positive PlGF test was found in 10 out of the 11 placental growth restriction cases and in4 out of the 89 constitutionally small fetuses. PlGF can differentiate between IUGR due to placental dysfunction from constitutionally smallfetuses with 90.1% sensitivity and 95.5% specificity. Conclusion: PlGF may serve as a promising tool to identify placental IUGR antenatally


Fetus --- growth --- placenta

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