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Article
Helicobacter Pylori Infection in Diabetic Patients

Author: Sabeha M. Al-Bayati
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2010 Volume: 9 Issue: 1 Pages: 31-34
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background H Pylori infection could be regarded as the commonest infection worldwide, it had been suggested that H pylori infection is more frequent among diabetics. Objective This study had been designed to define any significant association between diabetes and H pylori infection, to evaluate different demographic features of patients with diabetes mellitus who have H pylori infection, assess any relation between H pylori infection and the metabolic control of diabetes mellitus and to estimate the frequency of different oesophagogastroduodenoscopy findings among diabetic population with H pylori infection. Methods This study enrolled 50 patients with diabetes mellitus and another 50 non-diabetic patients (as a control group). The patients attended Gastrointestinal unit at Al-Yarmouk Teaching Hospital Baghdad/Iraq during the period between the 1st of March2004, to the 31st of November 2004. Full history was taken and clinical examination, investigation to assess the glycemic control and esophagogastroduodenoscopy (OGD)had been done to all of them. H pylori status had been detected by positive Rapid Urease test and histopathology and/or ELIZA test for anti-H pylori IgG. Results This study revealed that 26diabetic patients (52%) were H pylori positive, while 14 non-diabetic patients (28%) were H pylori positive which is statistically significant (X2=6.0,P=0.01). patients aging 60 year old or more (24 patients, 48% of the sample) 18 of them had positive H pylori status, 20 patients out of the 26patients with positive H pylori status (76.9%) had poor glycemic control, 84.6% of those with positive H pylori status (22 out of 26 patients) had glycated hemoglobin level of 8% and greater, 61.8% of those with positive H pylori status (16 patients) were diabetic for more than 10 years. 61.5% of those with positive H pylori status had one or more of the chronic diabetic complications, 12 patients had OGD finding consistent with duodenitis, all of them were H pylori positive, OGD examination revealed 20 cases without active disease, 18 of them had negative H pylori status. Conclusions This study indicates that Helicobacter pylori infection is more common in diabetic patients. Frequency of H pylori infection is higher among elderly diabetics, those with long standing, poorly controlled and with diabetic complications.


Article
The Detection of Neutrophiles in Gastric Mucosa of Patients Suspected to be Infected with Helicobacter Pylori Using Leukostix

Authors: Nassir Enssief Mohsun --- Raji H AL-Hadithi --- Suhaila Saadallah
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 4 Pages: 480-483
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Helicobacter pylori has been detected in many populations and associated with inflammation of gastro duodenal mucosa. Colonization of the stomach by Helicobacter pylori occurs in more than half of human population worldwide. It is the principle cause of chronic active gastritis, peptic ulcer and gastric cancer.OBJCTIVE:To detect neutrophiles in homogenates biopsied gastric mucosa semiquantitatively using rapid leukocyte strip test (leukostix).METHODS:A total of 115 patients (74 males, 41 females) referred to The Gastrointestinal Tract Center and Gastroscopy Department of Baghdad Medical City and subjected to gastroscopy were included in this study during the period from November 2004 to May 2005.RESULTS:The sensitivity and specificity of leukostix at the initial examination were 95.8%, 88.23% respectively.CONCLUSION:The leukostix test, using biopsied samples of gastric mucosa was excellent for quantitative determination of neutrophils in patients infected with H pylori


Article
Systemic Humoral Anti Helicobacter pylori Immune Response in Dyspeptic Patients

Author: Batool M. Mahdi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 2 Pages: 153-158
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Helicobacter pylori (HP) cause a continuous gastric inflammation in virtually all infected persons. It induces a vigorous systemic and mucosal humoral and cellular immune response. In spite of these responses, the vast majority of infected hosts are unable to clear the infection and it persists for decades.OBJECTIVE:Determination the humoral immune response to HP infection in dyspeptic patients.PATIENTS AND METHODS:The immunological serological tests were evaluated in 80 dyspeptic patients divided into two groups: (HP +) and (HP-). Levels of specific HP IgG antibodies were determined through a specific immunological non invasive Enzyme Linked Immuno Sorbent Assay (ELISA) test from Biohit PIC, Helsinki, Finland. Immunoglobulin levels and complement were done (IgG, IgA, IgM, C3 and C4) using single radial immune diffusion (BioMaghreb-Tunis).RESULT:About 62.5 % of dyspeptic patients had HP + infection. There was no significant differences between two groups in the levels of (IgG, IgA, IgM, C3 and C4) and most of them were within normal values.CONCLUSION:Humoral immune response had an important role in the control and limits the inflammation of gastric mucosa.


Article
The Detection of Neutrophiles in Gastric Mucosa of Patients Suspected to be Infected with Helicobacter Pylori Using Leukostix Nassir Enssief Mohsun*,

Authors: Suhaila Saadallah *** --- Raji H AL-Hadithi**,
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 4 Pages: 480-483
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Helicobacter pylori has been detected in many populations and associated with inflammation ofgastro duodenal mucosa. Colonization of the stomach by Helicobacter pylori occurs in more thanhalf of human population worldwide. It is the principle cause of chronic active gastritis, peptic ulcerand gastric cancer.OBJCTIVE:To detect neutrophiles in homogenates biopsied gastric mucosa semiquantitatively using rapidleukocyte strip test (leukostix).METHODS:A total of 115 patients (74 males, 41 females) referred to The Gastrointestinal Tract Center andGastroscopy Department of Baghdad Medical City and subjected to gastroscopy were included in thisstudy during the period from November 2004 to May 2005.RESULTS:The sensitivity and specificity of leukostix at the initial examination were 95.8%, 88.23%respectively.CONCLUSION:The leukostix test, using biopsied samples of gastric mucosa was excellent for quantitativedetermination of neutrophils in patients infected with H pylori.


Article
5- EVALUATION OF ENDOSCOPY BASED METHODS (HISTOPATHOLOGY, CYTOLOGY AND UREASE TEST) FOR THE DETECTION OF HELICOBACTER PYLORI

Authors: Sawsan S Al-Haroon --- Sarkis K Strak --- Rafid Adil Abood
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2009 Volume: 15 Issue: 1 Pages: 21-24
Publisher: Basrah University جامعة البصرة

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Abstract

This study aimed to assess the accuracy of histopathology, brush cytology, andurease test in the diagnosis of Helicobacter pylori and to evaluate the effect of testduration on the sensitivity and specificity of positive urease test for the detection of H.pylori.Fifty patients [25 patients with gastritis group A and 25 patients with duodenal ulcergroup B] selected from those attending endoscopy unit for dyspeptic symptoms, wereenrolled in the study. Four endoscopic biopsies were taken from each patient. Onebiopsy from each of antrum and body were obtained for urease test (Urease test wasread at 30 min, 1, 4 and 24 hour after biopsy insertion into the reagent), and onebiopsy from each of antrum and body were used for histopathological examination.Antral brush cytology was taken also from each patient. The patients were consideredH. pylori positive when minimum concordances of 2 out of 3 tests (Histopathology,brush cytology, and urease test) were positive.Fourteen patients were positive for H. pylori in group A, in comparison to seventeenpatients in group B. The sensitivities of the histopathological examination, brushcytology, and urease test at 24 hours in group (A) were 58%, 79%, and 93%respectively. Corresponding figures for the specificity were 100%, 91%, and 46%respectively. While in group (B) the sensitivities were 82%, 82%, and 100% and thespecificities were 100%, 100%, and 88% respectively.It is concluded that among the invasive methods, the association of the urease testwith brush cytology constituted the best choice for confirming the diagnosis of H.pylori, due to the high sensitivity of the urease test and high specificity of brushcytology.


Article
HELICOBACTER PYLORI INFECTION AMONG PATIENTS WITH DIABETES MELLITUS

Authors: Ali K Jumaa --- Sarkis K Strak
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2015 Volume: 21 Issue: 1 Pages: 12-17
Publisher: Basrah University جامعة البصرة

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Abstract

Helicobacter pylori (H. pylori) is a gram-negative bacterium that specifically colonizes the gastric epithelium causing many complications. The link between H. pylori infection and diabetes mellitus (DM) remains controversial. This study was conducted to determine the frequency of H. pylori infection among a group of subjects with DM and to compare it with that of an age and sex-matched group of non-diabetic subjects. This case control study was conducted in Al-Sadr Teaching Hospital, Basrah, Southern Iraq from January 2013 to September 2014 on 200 subjects aged ≥ 40 years, 100 diabetic and 100 non-diabetic subjects. All subjects were required to submit fresh stool samples which were tested for evidence of H.pylori infection by stool antigen positivity. Helicobacter pylori infection was detected in 43% of diabetic group and 25% of controls, which was found to be statistically significant ( p value=0.007). In conclusion, the present study suggests that diabetic subjects are at more risk for H. pylori infection in comparison to non - diabetic subjects. This association is found to be higher in those with long duration of DM and those with poor glycemic control.


Article
Association of Helicobacter Pylori Infection and Gastric Cancer

Author: Shurooq A. Lafta, Abdul Hussein M. ALFaisal
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2017 Volume: 16 Issue: 1 Pages: 1-9
Publisher: Baghdad University جامعة بغداد

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Abstract

Helicobacter pylori (H. pylori) is the most important etiologic factor for gastric cancer. It is one of the most common human pathogens, which colonizes in the mucus layer of the gastric epithelium in more than 50% of the population. The study include 78 samples of gastric cancer in addition to 42 blood samples. The results from 78 gastric cancer samples showed that gastric cancer can occur red at any age, but it increases in older ages and the incidence of H. pylori infected positive gastric cancer (HIP-GC) is higher than of H. pylori infected negative gastric cancer (HIN-GC). Male is the predominant in both groups and female affected by H. pylori more than male and the intestinal type was the predominant type.


Article
Evaluation of Anti-Helicobacter pylori IgG in Sera of Pregnant Women

Author: Samir Abdul Amir Abid Ali Alash
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2014 Volume: 17 Issue: 3 Pages: 108-110
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Helicobacter pylori is a bacterial infection of the stomach, which plays a major role in abdominal symptoms and gastroduodenal pathology. The pregnant women had a significantly higher relative risk of acquiring H.pylori infection during pregnancy as a result of physiological alterations. To investigate the relationship of H.pylori with dyspeptic symptoms in early and late pregnancy, thirty sera samples were obtained from pregnant women and thirty sera samples were obtained from apparently healthy women as control. All studied groups were evaluated anti-Helicobacter pylori IgG antibody by ELISA. Ten of pregnant women samples (33.3%) were seropositive of anti-H. pylori IgG antibody in pregnant women compared with control. This lead to suggest that H. pylori positive may be related to nausea and vomiting in pregnant women.

تعد بكتريا H.pylori احد انواع اصابات المعدة والتي تلعب دورا رئيسيا في اعراض البطن والامراض المعدية. تكتسب النساء الحوامل خطر الاصابة بهذه البكتريا كنتيجة الى التغيرات الفسيولوجية الحاصلة لديهم. لأجل التحري في مدى علاقة H.pylori مع اعراض عسر الهضم لدى النساء الحوامل في المراحل المبكرة والمتاخرة من الحمل، جمعت 30 عينة مصل دم من نساء حوامل و 30 عينة مصل دم من نساء غير حوامل سليمات ظاهرياً كمجموعة سيطرة، خضعت مجاميع الدراسة الى تقييم أضداد بكتيريا H. pylori من النوع IgG بأستخدام إختبار ELISA حيث أظهرت الدراسة أن 10 عينات من النساء الحوامل (33.3%) كانت مصولهن أيجابية لبكتيريا H. pylori. يمكن الأستنتاج من وجود أضداد بكتيريا H. pylori من النوع IgG في مصول النساء الحوامل ان له علاقة بأصابتهن بالغثيان والقيء.


Article
Evidence of Infection with Helicobacter Pylori in Patients With Acute Myocardial Infarction
الدليل على الإصابة بالهليكوباكتر بايلوري عند مرضى إحتشاء العضلة القلبية الحاد

Author: Dr. Ala Hussain Abbase Haider د علاء حسين عباس حيدر
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2009 Volume: 12 Issue: 1 Pages: 9-17
Publisher: University of Kufa جامعة الكوفة

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Abstract

Background: the role of infection with Helicobacter pylori (H. pylori) as a risk factor for acute myocardial infarction is controversial.Aim of the study: to assess the association between H. pylori infection and acute myocardial infarction. Patients and Methods: the IgG seropositivity to H. pylori was assessed in 40 patients with acute myocardial infarction and 39 controls. Results: in the total study the association was statistically insignificant (80% vs 69.2%, p value:0.2, OR 0.56, 95%CI(0.2-1.5)), but in those below the age of 50 years was significant (100% vs 66.7%, p value: 0.04, OR 2.3, 95%CI(1.4-4.02)). No association was found between H. pylori seropositivity and worsening of the classic coronary risk factors. Conclusion: this study suggests that H. pylori infection is a risk factor for coronary artery disease in patients below 50 years.

تمهيد: إن دور الإصابة بالهليكوباكتر بايلوري كعامل خطورة للإصابة بإحتشاء العضلة القلبية الحاد هو محل خلاف0 الأهـداف: تقييم العلاقة بين الإصابة بالهليكوباكتر بايلوري وبين احتشاء العضلة القلبية الحاد0 الطرق: في هذه الدراسة ذات مجموعة الضبط حُددت الموجبية المصلية للغلوبيولين المناعي جي المضاد للهليكوباكتر بايلوري عند 40 مريضاً مصاباً باحتشاء العضلة القلبية الحاد وعند 39 شخصاً من مجموعة الضبط0 النتائج: لم تكن النتائج معتبرة إحصائياً في عموم الدراسة (80% مقابل 69٫2% وكانت قيمة p 0٫2 وOR 0٫56 و95% CI (0٫2-1٫5))، ولكنها كانت معتبرة عند الأشخاص دون سن الـ 50 سنة (100% مقابل 66٫7% وقيمة p :0٫04 وOR 2٫3 و95% CI (1٫4-4٫02)). ولم تظهر هناك علاقة بين الموجبية المصلية للهليكوباكتر بايلوري وبين احتداد عوامل الخطورة الكلاسيكية لأمراض الشرايين التاجية0الإستنتاجات: إنّ هذه الدراسة تبيّن أنّ الإصابة بالهليكوباكتر بايلوري هو عامل خطورة لأمراض الشرايين التاجية في المجموعة العمرية التي هي دون الـ 50 سنة.


Article
Failure to detect Helicobacter pylori in tap water sources in Al- Najaf and Babylon provinces by using PCR based on ureB gene.
فشل في تشخيص الملوية البوابية من مصادر مياه الاسالة في محافظتي النجف وبابل باستخدام تفاعل البلمرة المتسلسلة واعتمادا على اليوريا بي جين

Authors: O.M.Hadi عدي متعب هادي --- R. H. Fadel رضية حسين فاضل --- H. K. Hussein همام قاسم حسين
Journal: Al-Qadisiyah Journal of Veterinary Medicine Sciences مجلة القادسية لعلوم الطب البيطري ISSN: 18185746 23134429 Year: 2013 Volume: 12 Issue: 1 Pages: 162-171
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

(500) sample collected from the study area, divided into (250) from the province of Najaf and (250) from the province of Babylon, and distributed by two models for each sample. I use the first model to estimate the level of free chloride , pH, dissolved substances college and temperature, while the use the other form of the same sample to check for the presence of bacteria in tap water in a PCR study showed a large disparity in the levels of pH, free chlorine, dissolved substances college and the temperature you two provinces were the highest percentages for the Abbasia in Najaf Ashraf and the least in the Alhaidariya in the same province study also demonstrated the existence of significant correlation between the level of free chloride each of the temperature, dissolved substances College and the pH while the highest in the region of Mahaweel in the province of Babylon, and the least in Jordan in the same area of the province and which should be mentioned to him the failure mode (PCR) in detecting the presence of Helicobacter pylori bacteria in tap water in the both provinces .H.pylori :- Helicobacter pylori .T D S :- Total dissolved solids .PCR :- Polymerase chain reaction

جمعت 500 عينة من منطقة الدراسة, مقسمة الى (250 ) عينة من محافظة النجف و ( 250) عينة من محافظة بابل ووزعت بواقع نموذجين لكل عينة . أستعمل النموذج الاول لتقدير مستوى الكلورالحر ,الاس الهيدروجيني , المواد الصلبة الذائبة ودرجة الحرارة في حين تم أستعمل النموذج الاخر لنفس العينة للتحري عن وجود جرثومة H.plori في ماء الحنفية بطريقة PCR أظهرت الدراسة وجود تباين كبير في مستويات الاس الهيدروجيني, الكلور الحر , المواد الصلبةالذائبة ودرجة الحرارة في محافضتي النجف الاشرف وبابل كما وتبين ان استعمال PCR للكشف عن الجرثومة لم يعطي اي نتيجة ايجابية وكانت اعلى النسب لمنطقة العباسية في النجف اشرف واقلها في منطقة الحيدرية في نفس المحافظة كما بينت الدراسة وجود ارتباط معنوي بين مستوى الكلور الحرمع كل من درجة الحرارة , المواد الذائبة الكلية و الاس الهيدروجيني بينما كانت اعلى النسب في منطقة المحاويل في محافظة بابل واقلها في منطقة الهاشمية في نفس المحافظة ومما تجدر الاشارة اليه انة لم يتم الكشف عن الجرثومة في ماء الحنفية لكلا المحافظتين .

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