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Article
Prevalence of Fibromyalgia in Iraqi Patients with Ischemic Heart Disease

Authors: Ziad S.Al-Rawi* DPM --- Faiq I. Gorial** CABM, FIBMS --- Khudhir M. Al-Bidri* FIBMS (Int. Med), FIBMS
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 2 Pages: 127-129
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Fibromyalgia has been associated with physical and emotional trauma including invasive medical procedures. Both Fibromyalgia and ischemic heart disease have been linked with depression. The aim of the study is to assess the prevalence of fibromyalgia syndrome in patients with ischemic heart disease.Patients and Methods: A cross-sectional comparative study was done in the Iraqi Center for Heart Disease. One hundred patients, angiographically proved to have ischemic heart disease, were subjected to rheumatologic examination by another physician, and compared to hundred healthy individuals as a control group. Diagnosis of fibromyalgia was based on 1990 American College of Rheumatology Classification criteria for the diagnosis of fibromyalgia.Results: Eighteen (18%) patients with ischemic heart disease fulfilled the American College of Rheumatology criteria for fibromyalgia syndrome in comparison to only 6(6%) of the controls, and this difference is statistically significant (P-value = 0.009).There were statistical significant effects of gender, age, and number of coronary vessels on the prevalence of fibromyalgia syndrome. Conclusion: fibromyalgia occurs with high frequency (18%) in patients with ischemic heart disease.


Article
Serum and Erythrocyte Magnesium Levels in Patients with Myocardial Infarction with or without Heart Failure

Authors: Laith S. Abdul-Al Haliim Al-Naqib --- Ahsan K. Abbas --- Basil N. Saeed*
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: 3 Pages: 372-375
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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BACKGROUND :Magnesium (( Mg(1) )) is a mineral that is involved in over 300 reactions in the body. Magnesium is aPotent vasodilation ,and plays an important role in muscle contraction. It has been earlydocumented that Mg deficiency can precipitate ventricular arrhythmias and treatment with Mg hassome anti arrythmic effect. Moreover there is an ample evidence that a significant percentage ofpatients with IHD suffer from Mg. The risk of IHD increaseswith age, smoking, hypercholesterolaemia,diabetes mellitus, hypertension(1). Ischemic heartdisease presented as stable angina , unstableangina , myocardial infarction , ischemic heartfailure and ischemic cardiomyopathy. Thediagnosis of ischemic heart disease depend onclinical history and investigation including: *Ministry of Health AL-Bitar Hospital,Baghdad.Iraq.**Biochemistry Dept. Collage of Medicine University of Baghdad.*** Dept. Baghdad Medicine City. deficiency.OBJECTIVE : The objective of the present study is to measure Mg(2) levels in serum and RBCs of patients withsome forms of IHD. PATIENTS AND METHODS:The study was conducted in Baghdad hospital and Ibn – Al-Bitar Hospital.The 180 patients withIHD were divided into Two groups. Group I, 80 patients with Ischemic Heart Failure (IHF)(EF˂30) aged 65.75±5.97 year (50 males and 30 females), group II, 100 patients withMuocardial Infarction (MI)(EF˂50) aged 50.34±6.36 year (58 males and 42 females). Serum Mg and RBCs Mg weremeasured in all patient groups by Atomic Absorption Spectrophotometer.RESULTS: The(mean ±SD) value of serum and RBCs Mg in patients with both groups Ischemic Heart Disease(IHD) was significantly lower when compared with that of controls (p<0.05).The serum Mg levels (0.81±SD mmol/L) are significantly lower in the IHF group and in MI group (0.96±0.18 mmol/L)when compared with that of controls (1.00±0.17 mmol/L) (p˂ 0.001).CONCLUSION: The data obtained in present study revealed the decrease of Mg level in serum and RBCs in bothpatients groups, which affect the contractility of heart muscle and cardiac performance


Article
Clinical and Angiographic Findings in Diabetic Versus Non-Diabetic Iraqi Patients with Ischemic Heart Disease (A Single Center Experience)

Author: Muataz Fawzi Hussein
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 3 Pages: 339-346
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Diabetes mellitus (DM) is a common, chronic and complex metabolic disorder. Its direct and indirect effects on the vascular system are major causes of morbidity and mortality.OBJECTIVE:To verify the effects of diabetes mellitus on clinical presentation and angiographic findings in diabetic patients with ischemic heart disease as compared to non diabetic patients.PATIENTS AND METHODS:This cross-sectional descriptive study was conducted in the Iraqi Center of Heart Diseases during the period from November 2008 till June 2009. Two-hundred patients with ischemic heart disease (IHD) who were referred to the Iraqi Center for Heart Diseases were randomly included. Clinical history and examination were done; blood tests, electrocardiography and echocardiography were done for all patients. Patients were classified into 2 groups: 68 patients with diabetes mellitus and 132 patients without diabetes mellitus. Coronary angiography was done for all patients and the results were interpreted by two independent interventional cardiologists.RESULTS :There were 145 (72.5 %) males and 55 (27.5 %) females. The mean age of study population was 56.92 ± 3.9 years (56.57 ± 3.2 years for males, 57.91 ± 4.1 years for females).There were no statistically significant differences between diabetic and diabetic patients regarding sex, age, type of clinical presentation, presence of hypertension and family history of coronary heart disease. Diabetic patients were more likely to be smoker (61.7% vs. 48.4%, P = 0.01), to have dyslipidemia (53% vs. 35%, P = 0.03), left ventricular systolic dysfunction (61.7% vs. 48.4%, P = 0.045) left ventricular diastolic dysfunction (92.6% vs. 58.3%, P =0.03), more diseased coronary arteries (38.2% vs. 25.7%, P =0.009), more frequent left main stem involvement (13.2% vs. 3.8%, P =0.008) and more complex coronary lesions (60.2% vs 31.8%, P =0.00002).CONCLUSION:Diabetic mellitus has clear adverse effects on left ventricular systolic and diastolic functions and angiographic findings in patients with ischemic heart disease


Article
HLA prevalence in Iraqi patients with ischemic heart disease

Authors: Eman Sh. AL-Obeidy --- Basil N. AL-Dileamy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 2 Pages: 182-184
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The etiology of ischemic heart disease (IHD) is believed to have an immunological component. Association with human leukocyte antigens (HLAs) has been previously reported, particularly with DR6.Patients and methods: 75 cardiac patients were admitted to the coronary care unit, Baghdad Teaching Hospital over the period October 2008-May 2009 with the clinical diagnosis of acute coronary syndrome and STEMI myocardial infarction their ages range was (25-82) years the number of male was (55) (73.3%) and female was (20) (26.7%). All cases have routine ECG, cardiac marker’s measurements, routine haematological, Biochemical test and 2mls of blood reserved for HLA study.
Results: It was found that HLA-DR1 (8%) (P 0.001) has significant risk factor in the development of ischemic heart disease while HLA B (62%) (P 0.0009) has a protection factor in ischemic heart disease.
Conclusions: Our result suggests that strong relation between the incidence of acute ischemic episode (acute coronary syndrome and STEMS myocardial infarction and HLA-DR1) which mean that there may be predisposing genetic factor for the development ischemic heart disease.


Article
Evaluation of Amino acid Homocysteine in Hypertensive Patients

Author: Ali Taqi. Al-Baldawi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 2 Pages: 151-154
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT :BACKGROUND :Hypertension is a world wide disease and in 90% of cases the cause is unknown . Its early detectionand treatment can prevent serious complications such as ischemic heart disease (IHD) . Furthermorethe association of lipids with IHD is a well-known fact . However abnormally high levels ofhomocysteine were found to be strongly linked to an increase risk of coronary artery disease .OBJECTIVES:To evaluate the total plasma homocysteine concentration in hypertensive patients.METHODS :Total plasma homocystein concentrations were measured using High Performance LiquidChromatography(HPLC) with Ultraviolet( UV) detector in 60 hypertensive patients (27 male and 33female) aged 35 years and more . Cholesterol , triglyceride , HDL-cholesterol , LDL-cholesterol ,VLDL-cholesterol were determined .The prevalence of high total homocysteine values were determinedby comparison with normal reference population.RESULTS :Total plasma homocysteine levels were significantly higher in patients than in normal population. Totalserum cholesterol and triglyceride concentrations were also significantly higher in patients than innormal population with no association to the level of homocysteine which is regarded as a specialindependent vascular risk factor.CONCLUSION :The study involves the evaluation of homocysteine in hypertensive patients plasma homocysteinelevels were significantly higher in patients than in control groups. There were no significant differencesbetween male and female patients.


Article
Female Pattern Alopecia and Lipoproteins

Authors: Khalifa E. Sharquie --- Adil A. Noaimi --- Husam Ali Salman --- Nibras A. Hindy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 2 Pages: 120-122
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:The meaningful association of androgenetic alopecia and coronary heart disease had been well documented, but few studies had been focused on the importance of lipid parameters in patients with androgenetic alopecia.OBJECTIVE:To investigate the lipid profile and its relation to female pattern alopecia.PATIENTS & METHODS:This is a case controlled study conducted at the Department of Dermatology & Venereology- Baghdad Teaching Hospital, between January 2001 and April 2002. Sixty female patients with androgenetic alopecia were enrolled in this work. From each patient a detailed history and full clinical examination were performed regarding all demographic points relative to the disease, grading of alopecia and measurement of serum lipoproteins was done. Female pattern alopecia was classified according to Sharquei’s classificationSixty age and weight matched females with normal hair status were considered as a control group. Measurement of serum lipoproteins also performed for them.RESULT:Sixty patients, their ages ranged between 20-60 years with mean + SD of 30.3 + 9.4 years. Twenty (33.3%) patients were having grade I, 20 (33.3%) patients grade II and another 20 (33.3%) patients grade III.. The mean levels of total serum cholesterol, triglycerides, low density lipoprotein and very low density lipoprotein in all patients and those with grade II and III separately were significantly higher when compared to the control group. On the other hand, the mean levels of high density lipoprotein in all patients and those with grade I and III separately were lower in comparison to the control.CONCLUSION:The atherogenic index or risk ratio was found to be significantly high in patients with female patteren alopecia and this goes parallel with the severity of baldness.


Article
Is Chlamydia Pneumonia An Independent Risk Factor In Ischemic Heart Disease

Authors: Eman Sh. AL-Obeidy --- Eman Sh. AL-Obeidy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 2 Pages: 151-154
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Immune system may interplay between Chlamydia pneumoniae infection and ischemic heart disease (IHD).Major histocompatibility genes regulate innate and adaptive immunity..OBJECTIVE:This study was established to shed light on the possible association between ischemic heart disease (IHD) with Chlamydia pneumoniae infection and HLA antigens.PATIENTS AND METHODS:Microlymphocytotoxicity assay has been applied for HLA-typing of 150 blood samples of 100 IHD patients and 50 healthy normal controls, In addition enzyme linked immunosorbant assay (ELISA) used to detedct C pnuminiae IgA and IgG.RESULTS:An increased frequency of HLA-A*2, B*35 alleland HLA-A*2-B*35 haplotype was observed for patients group versus control group with P-value (0.0001, 0.05, and 0.001) respectively.CONCLUSION:This finding demonstrated that the HLA-B*35 positive haplotypes confer the C.pneumoniae-related risk for IHD. HLA-DR3,DR4 and DR7 might play a role in AIH susceptibility


Article
Cystatin-C marker in diabetic and non diabetic patients with ischemic heart disease
قياس السستاتين سي لدى المرضى المصابين بقصور الدورة التاجية المصاحب لداء السكري او بدونه

Author: Shaimaa S. Mutlak شيماء سبتي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2012 Volume: 54 Issue: 2 Pages: 176-178
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:recent data indicate the prevalence of cardiovascular disease in patientswith high cystatin-C level;it can be used as a good predictor for assessment of mortality in cardiovascular diseases regardless of the status of renal function.Patients and methods: Onehundred twenty (120) patients with ischemic heart disease admitted to this study at Baghdad teaching hospital for the period from January 2011 to September2011,Those patients categorized into two groups (60) diabetic and (60) non diabetic in comparison to fifty healthy control.Fasting serum cystatin-C was measured in all patients and controls.Results: The level of serum cystatin-C, in diabetic patients with ischemic heart disease was (2.05±0.55 µg/L). Its level in non diabetic patients with ischemic heart disease was (1.19±0.59 µg/L)both were significantly higher(p<0.001)than its level in healthy control(0.38±0.062 µg/L).Conclusion:Cystatin-C is good prognostic biomarker in patients with ischemic heart disease with or without diabetes mellitus.Keyword:cystatin-C, ischemic heart disease, diabetes mellitus.

دلت الاحصاءات الحالية على إنتشار أمراض القلب عند الاشخاص الذي يكون مستوى السستاتين لديهم عالي مما يساعد في إعتباره مؤشرلتقييم نسبة المرض ومعدل الوفيات لدى الاشخاص بصرف النظر عن حالة فعالية الكلى. شملت الدراسة (120) مريضا مصابا بقصور الدورة التاجية من الذين ادخلو الى مستشفى بغداد التعليمي للفترة من كانون الثاني 2011 ولغاية حزيران 2011.قسم المرضى الى مجموعتين 60 مريض مصاب بقصور الدورة التاجية بالاضافة الى داء السكري و60 مريض مصاب فقط بقصور الدورة التاجية بالاضافة الى 50 شخص من الاصحاء (المجموعة الضابطة) .تم قياس مستوى السستاتين سي في مصل كل من المرضى و الاصحاء وأظهرت النتائج ان مستوى السستاتين في مصل المرضى المصابين بقصور الدورة التاجية بالاضافة لداء السكري وكذلك لدى المرضى المصابين بقصور الدورة التاجية فقط كان مرتفعا مقارنة بمجموعة الاصحاء .P<0.001 الاستنتاج: يعتبر السستاتين سي مؤشر انذاري لدى المرضى المصابين بقصور الدورة التاجية مع او بدون داء السكري.


Article
Ischemic Heart Disease Mortality, Morbidity and Risk Factors of Coronary Care Unit Patients

Author: Ali Hussein Salih
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2014 Volume: 7 Issue: 1 Pages: 35-40
Publisher: Diyala University جامعة ديالى

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Background: Ischemic heart disease (IHD) is the commonest type of heart disease .It causes more deaths and disability and incurs greater economic costs than any other illness. Gender, age, hypertension, diabetes mellitus, smoking, hyperlipidemia and family history are obvious risk factors. In acute state it may be complicated by life threatening arrhythmia, heart failure, circulatory failure and cerebrovascular accidents.Aims of study: To evaluate the patients with ischemic heart disease admitted to the coronary care unit of Baquba teaching hospitalPatients and Methods: A total of 160 cases of patients with various symptoms of ischemic heart disease including chest pain, dyspnea, and palpitation are evaluated in the coronary care unit of Baquba teaching hospital by history taking, physical examination, and Electrocardiogram, echocardiogram, and lab tests with continuous follow up until discharge from the coronary care unit.Results: From total number 97(60.62%) patients were males,58 have myocardial infarction and 39 have angina .The rest of the patients were females 63 (39.38%),41 of them have angina and 22 have myocardial infarction. Male was the highest risk factor followed by hypertension, diabetes mellitus, smoking family history and hyperlipidemia .Arrhythmia is the commonest complication while heart failure, cerebrovascular accident and circulatory failure of lesser frequency .


Article
Association of Adiponectin Gene Promoter Polymprphism (rs266729) With Ischemic Heart Diseases

Authors: Maha Radhi Abass --- Majid Kadhum Hussain --- Zuhair Mohammed Ali Jeddoa
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2018 Volume: 11 Issue: 1 Pages: 3889-3893
Publisher: Kerbala University جامعة كربلاء

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background: Ischemic Heart Disease is a group of diseases of the blood vessels supplying the heart muscle. Adiponectin is a protein secreted by adipocyte with insulin-sensitizing, Anti-inflammatory and anti-atherogenic properties. Several studies have shown that polymorphisms within the adiponectin gene can be associated with Ischemic heart disease. Aim: The aim of the present study was to evaluate the impact of (rs266729) SNP in the promoter region of the ADIPOQ gene on the occurrence of Ischemic heart disease (IHD).Methods: The study included 150 patients with IHD randomly selected based on World Health Organization (WHO) guideline and 150 as controls group. DNA was extracted from blood and genotyped by PCR-RFLP by using (Hha1) enzyme. Result: The frequency of G allele of rs266729 (C/G) polymorphism was significantly (p=0.0001) in IHD (19.6%) compared with control (13.3%). The homozygous genotype (GG) significantly (0R=1.71, CI 95%=0.65-4.96, P= 0.0001) increased the risk of Ischemic Heart Disease compared with wild type (CC) after adjustment age, sex, and BMI, furthermore the heterozygous (CG) genotype significantly (0R=1.61, CI 95%=0.96-2.87, P= 0.0001) raised the risk of Ischemic Heart Disease.Conclusion: Adiponectin gene polymorphism rs266729 is involved in the pathogenesis Ischemic heart disease.

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