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Article
Platelet indices and their relations to platelet count in hypo-productive and hyper-destructive Thrombocytopenia

Authors: Khaleed Jumaa Khaleel --- Abeer Anwer Ahmed
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2014 Volume: 7 Issue: 2 Pages: 1952-1958
Publisher: Kerbala University جامعة كربلاء

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Abstract

ackground: Thrombocytopenia is low platelets count which is either due to defective platelet production (hypo-productive thrombocytopenia) or due to increased platelet breakdown (hyper-destructive thrombocytopenia). Measurement of platelet counts alone do not explain the underlying patho-mechanism of thrombocytopenia.. Recent advances in automated blood cell analyzers facilitate the measurement of several blood cell parameters automatically such as, platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) and these parameters could provide some important clinical information.Aim of the study: to investigate whether platelet indices( MPV,PDW,PCT) could serve as diagnostic tools in the differential diagnosis of thrombocytopenia and, if there is any correlation between platelet count and platelets indices .Subjects and Methods: A total of 77 Iraqi patients (28 males and 49 females) with thrombocytopenia were subjected to the following tests:1. Complete blood count using Mindway haematologic autoanalyser.2. Peripheral blood film .3. Bone marrow aspirate with bone marrow trephine biopsy when indicated.A group of 50 healthy person (age & sex matched) were included as a controlResults: hyper-destructive thrombocytopenia (immune thrombocytopenia) representing 12.9% of total patients, while hypo-productive thrombocytopenia due to various causes representing 87.1% of total patients. The MPV, PDW are significantly higher in immune thrombocytopenia group as compared with thrombocytopenia of hypo-productive patho-mechanism and there were no correlations between platelets count and both MPV and PDW in hyper-destructive and hypo-productive thrombocytopenia but there was a direct correlation between platelet count and PCT .Conclusion: Platelet indices provide plenty of clinical information about the causes and patho-mechanism of thrombocytopenia and could be helpful tests to distinguish hyper-destructive thrombocytopenia from hypo-productive thrombocytopenia easily, so more interest for the use of these indices in differential diagnosis of thrombocytopenia is required.


Article
SIGNIFICANCE OF PLATELET INDICES IN PATIENTS WITH ACUTE ISCHEMIC STROKE

Authors: Waseem F Al-Tameemi وسيم فاضل محمد التميمي --- Ameer MM Ameen امير محمد امين
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2012 Volume: 10 Issue: 4 Pages: 383-389
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background :Platelets play an important role in the development of intravascular thrombosis. Platelet size has been considered to reflect platelet activity. Platelet indices had been studied as an independent predictor of acute ischemic stroke (IS).Objectives:Assessing the relation of acute IS with different platelet indices.Methods:Fifty patients were enrolled: 25 of them had first acute IS (mean age 64 years, 12 (48%) were males) [group 1], while the rest 25 patients were those with more than one IS (mean age 68 years, 16 (64%) were males) [group 2] in comparison with the control group (20) subjects (mean age 57 years, 10 (50%) males). Work up included history and clinical examination in addition to brain CT scan and platelet indices which are: mean platelet count (MPC), mean platelet volume (MPV), platelet large cell ratio (P-LCR), and platelet distribution width (PDW) within first 24 hours of patient presentation.Results:The mean platelet count (MPC) was found to show significant difference between group 2 versus group 1 and control (P=0.012, P=0.023 respectively), while no statistically significant differences were reported with the other indices (MPV, PDW or P-LCR). Linear negative correlation was demonstrated between MPC and MPV, PDW and P-LCR in group 1, such correlation wasn't found in group 2.Conclusion:Mean platelet count (MPC) differs significantly in cases of multiple stokes in comparison with those having first stroke or the control group; therefore, the significance of this finding needs further studies.Keywords:Platelet indices, platelet count, mean platelet volume, platelet distribution width, platelet-large cell ratio, ischemic stroke.


Article
Platelets Count, Indices And Fibrinogen Level In Patients With Preeclampsia Compared To Normal Pregnant Women
عدد الصفيحات الدموية , عوامل الصفيحات الدموية,ومستوىالفايبرينوجين في النساء ذوات ضغط الدم المرتفع أثناء الحمل(ما قبل الارجاج)مقارنة بذوات الحمل الطبيعي

Authors: Sawsan Talib Salman سوسن طالب سلمان --- Asil Hashim Ali أسيل هاشم علي --- Inaam Faisal انعام فيصل
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2017 Volume: 16 Issue: 1 Pages: 58-62
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Preeclampsia (PE) is a pregnancy specific syndrome that affects 6–8% of pregnancies worldwide. The specific pathogenesis of preeclampsia remains incompletely elucidated. Many tests have attempted to establish the diagnosis of preeclampsia as early as possible, often even before the patients develop arterial hypertension.Objective: This study aims to identify whether the platelet indices and fibrinogen level are significantly affected by preeclampsia compared to normal pregnancy Patients and methods :This retrospective case-control study was done in AL- Batool Teaching Hospital-Department of Obstetrics and Gynecology, from the 1st of September 2014 to 30th of September 2015 , 75 woman who fulfill the inclusion criteria were included in the study , they were divided into two groups 25 pregnant woman with preeclampsia & 50 normal pregnant woman as control group(were all normotensive pregnant woman with single intrauterine gestation and the obstetric history is uneventful ) . Results: Systolic, diastolic & MAP were highly different between the control & the patient groups. Regarding fibrinogen level it was lower in the patients with preeclampsia. Platelet count was also reduced in preeclamptic patients. While all platelet indices were higher in the patient group compared to the control group.Conclusion: Platelet indices and fibrinogen level can be used in predicting preeclampsia.

خلفية الموضوع: إن ارتفاع ضغط الدم الشرياني أثناء الحمل (ما قبل الارجاج) هي إحدى الحالات التي تصيب ما بين 6_8% من النساء الحوامل في العالم 0 إن السبب الرئيسي للمرض غير معرف تماما0هناك عده فحوصات مختبريه أجريت في محاوله لتشخيص المرض مبكرا قدر الامكان0حتى قبل إن يرتفع ضغط الدم عند المريضه0أهداف الدراسة:الغرض من الدراسة هو لمعرفه هل إن عوامل الصفيحات الدموية ومستوى الفايبرينوجين يتأثران بشكل واضح بارتفاع ضغط الدم(ما قبل الارجاج)مقارنه بالحمل الطبيعيطريقه الدراسة: دراسة رجعيه أجريت في قسم النسائية والتوليد في مستشفى البتول التعليمي-ديالى-العراق0للفتره من الأول من ايلول2014 إلى الثلاثون من أيلول 2015. تضمنت الدراسة 75 مريضه لها نفس الصفات الديموغرافيه وقد تم تقسيم المريضات إلى مجموعتين:الاولى50 أمراه حامل مصابه بارتفاع ضغط الدم أثناء الحمل والمجموعة الثانيه25 مريضه لا تعاني من المرض إن مده الحمل قدر اعتمادا على الفحص بالأمواج فوق الصوتية(السونار)خلال الأسابيع الأولى للحمل0النتائج:لوحظ إن مستوى الفايبرينوجين كان اقل لدى المريضات اللواتي يعانين من ارتفاع الضغط أثناء الحمل وكذلك عدد الصفيحات الدمويه0بينما عوامل الصفيحات الدموية كانت أعلى لدى المريضات اللواتي لديهن ارتفاع ضغط الدم أثناء الحمل0الاستنتاج:مستوىالفايبرينوجين وعوامل الصفيحات الدموية لها قيمه تنبؤيه في حالات ارتفاع الضغط أثناء الحمل0

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