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Article
Effect of the Biological Drug Etanercept on Tumor necrosis factor-α Levels in Psoriatic Patients

Authors: Basman Medhat Fadheel --- Ban Noori Al-Qadhi --- Rasha Hussain Kuba
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2018 Volume: 59 Issue: 2C Pages: 998-1005
Publisher: Baghdad University جامعة بغداد

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Abstract

Psoriasis is a common, chronic, immune mediated disorder.The disease is arising as a result of dysregulated interactions of the innate and adaptive immune system in the context of skin epithelium and connective tissue. The biological drug Etanercept(ETN) approved for use in treated psoriasis. ETN is tumor necrosis factor- α (TNF-α) inhibitor. In this study, 48 psoriatic patients were taken before and after treatment who attended to the Dermatology and Venereology Department in Baghdad Teaching Hospital during the period from December 2016 to September 2017and 50 samples were used as healthy control group. The results showed that most psoriatic patients 52.08 % were within the second and third decades 20-35 year, and the majority of psoriatic patients were males 62.5% and the ratio of male to female is 1.67:1. Moreover, the results demonstrated that the males were more expected psoriasis compare with females. Blood samples were collected and TNF- α was estimated in sera of all subjects by using Enzyme Linked Immunosorbent Assay (ELISA). The TNF- α mean levels in psoriatic patients before treatment was 189.5±26.0 ng/ml, and after treatment was 223.6±41.1 ng/ml compar with the healthy control group 93.5±2.4 ng/ml. The results showed significant differences between the studied groups


Article
The Role of IL-1 and Tumor Necrosis Factor-α in Pathogenesis of Rheumatoid Arthritis

Authors: Eman Sh.Al-Obeidy --- Shatha F. Abdullah
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 2 Pages: 161-165
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Rheumatoid Arthritis (RA) is a common chronic inflammatory and destructive arthropathy that cannot be cured.Interlukin-1 (IL-1), IL-6 and tumor necrosis factor (TNF- α) are the key cytokines that drive inflammation in the disease.OBJECTIVE:The study was established to shed light on the possible role of IL-1 and TNF- α in pathogenesis of RA.PATIENTS AND METHODS:Rheumatoid Factors (RF),TNF-α and IL-1 were detected by Enzyme-Linked Immunosorbent Assay (ELISA) .C-reactive protein(CRP) on the other hand has been detected by using latex agglutination kit in the serum of 50 Iraqi patients with RA in comparison with 50 healthy individuals.RESULTS:Significant high levels of IL-1and TNF- α were observed in RA patients sera with P-value ( 0.04 and 0.001) respectively compared to healthy control group, in addition a positive linear association was found between the concentration of IL-1and TNF- α and CRP with P-value ( 0.05 and 0.001) respectively.CONCLUSION:IL-1and TNF- α play a role in pathogenesis of RA


Article
Cytokine Profile in Patients with Rheumatoid Arthritis

Author: Falah S. Manhal* PhD د. فلاح سالم منهل
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 4 Pages: 433-436
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:Background: Cytokines produced by inflammatory cells play a pivotal role in synovial inflammation and joint destruction in rheumatoid arthritis.Patients and Methods: The cytokine serum levels were measured by EASIA (Enzyme amplified sensitivity immunoassay) in sera from 50 RA patients, and 40 healthy donors. Cytokine levels were compared in different RA subpopulations (positive or negative rheumatoid factor (RF), long term or recent onset disease, high or low disease activity). In addition, the possible association with other demographic and clinical parameters (gender, age, etc) was also analyzed. Results: It was demonstrated that IL-2, IL-6 and IFN-δ levels were elevated in serum samples of RA patients as compared with apparently healthy controls. Maximum elevation of TNF-α was recorded in a few number of patient's sera. There were non significant differences between control and RA patient groups in serum TNF-α level. Conclusions: Assessing the serum IL-2, IL-6, IFN-δ and TNF-α levels may be helpful in the confirmation of the RA activity. Due to the chronic course of this disease, other inflammatory markers must be identified in order to provide early therapeutic strategies to these patients.Key words: Rheumatoid Arthritis, Interleukine-2, Interleukine-6, Tumor Necrosis Factor- α, Interferon- δ.


Article
Effect of non surgical periodontal treatment on TNF-α levels in serum of patients with chronic periodontitis
تأثير علاج اللثة غير الجراحي على مستويات TNF-α في مصل المرضى الذين يعانون من التهاب اللثة المزمن

Authors: Haween T. Nanakaly --- Sazan Sartip Abdulhameed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2016 Volume: 20 Issue: 1 Pages: 1167-1174
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Chronic periodontitis is a multifactorial inflammatory disease characterized by destruction of tooth supporting tissues. Tumor necrosis factor-α, a key inflammatory cytokine, plays an important role in periodontal destruction. This study aimed to analyze the effect of non-surgical periodontal treatment on tumor necrosis factor-α levels in serum of patient with chronic periodontitis (with and without using chlorhexidine 0.2% mouthwash).Methods: A total of 44 patients with moderate to severe localized chronic periodontitis were divided into: Group I (n=22) without using of chlorhexidine mouthwash and Group II (n=22) with 0.2% chlorhexidine mouthwash. Serum samples collected from each subjectsat baseline and four weeks after scaling and root planning treatment were quantified fortumor necrosis factor-α levels using ELISA technique.Results: The mean concentration of TNF-α were significantly reduced one month after treatment in sera of patients with chronic periodontitis for group I when compared to its mean concentration before treatment (P <0.05), while in group II a highly significant reduction after one month treatment (P <0.001) was observed.Conclusion: The effect of non-surgical periodontal therapy with chlorohexidine mouth wash showed more reduction in the levels of serum tumor necrosis factor-α.


Article
Study of Serum Level of Interleukin 2, Interleukin 10 and Tumor necrosis factor-α in sample of Iraqi psoriasis patients

Author: ss. Prof. Dr. Talib Abdulla Hussein Azhar Jassim Mohsen Hind yousif khalaf
Journal: journal of the college of basic education مجلة كلية التربية الاساسية ISSN: 18157467 Year: 2016 Volume: 21 Issue: 91/علمي Pages: 1-12
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract :The aim of this study was to determine the Th1 and Th2 serum cytokines, in patients with psoriasis and to compare their cytokine levels with those of normal control subjects. where study included 55 Iraqi patients with psoriasis:30 (15 females ,15 males) were untreated with any drugs. The other patient group consist of 25 (9 female and 16 male) treated with a biological treatment (infliximab) ,and 30 healthy control group were withdrawn (5) ml of venous blood for both patients and members of the control ,to conduct Immunological tests to determine the quantitative for each of level of IL-2,IL-10 and TNF-α in a manner (ELISA). The results showed significant increase in the level of probability (P <0.05) in the rate of level of IL-10 and TNF-α in patients compared to the control (healthy) .As well as the result also show no significant increases of IL-2.From this we can deduce that pro inflammatory and anti-inflammatory cytokines have an important role in the pathogenesis of psoriasis, the increase of IL-10 and TNF-α indicated the balance between the proinflammatory and the anti-inflammatory cytokine .

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