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Article
Effect of infection on semen parameters in a sample of Iraqi infertile males.

Authors: Jawad K. Al-Diwan --- Eman Al-Kaseer --- Ali A. Lazem
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 3 Pages: 272-274
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Several studies were carried out on association of infection with male infertility, which revealed great variations in the prevalence of genital infection in different parts of the world. This work was designed to study the effect of infection on semen parameters in a sample of Iraqi infertile males.Methods: A sample of 400 infertile male patients attending the High Institute for Embryo Research and Infertility Treatment for laboratory investigations and treatment were selected. This study was carried out during the period Nov. 2002 to April 2003, inclusive. Seminal fluid analysis was performed on samples obtained by masturbation into a glass container after 48 to 72 hours from of abstinence from sexual intercourse. Analysis (examination of volume, liquifaction, sperm count, motility percent, normal morphology percent and presence of pus cells) was performed within an hour after ejaculation. Results: Clinical infection was detected in 14% of infertile males and 29% had subclinical infection. Liquifcation time and leukocyte had significant variation between infected and non infected patients. Conclusion: Early diagnosis and treatment of genitourinary infection in necessary to reduce complication and infertility in future.

Keywords

Infertility --- semen --- infection --- Iraq


Article
Etiology of infertility in couples attending maternity hospital in Erbil
مسببات العقم عند الأزواج الذين يذهبون إلى مستشفى الولادة في أربيل

Authors: Khanzad Hadi Rashid --- Aza Bahadeen Taha
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2013 Volume: 17 Issue: 1 Pages: 322-330
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Infertility remains a global health challenge with devastating psycho-social consequences in many communities and an underlying long-term risk for separation of the couple, also remains a major clinical and social problem. Infertility is defined as inability of a couple to conceive naturally after one year of intercourse. An understanding of the medical causes of infertility is crucial in order to reduce incidences of infertility and for improving the clinical management of infertility. The aim of the study was to determine the causes of infertility in couples. Methods: A retrospective study was done in IVF Unit at Maternity Teaching Hospital in Erbil. Data of infertile couples were collected from already prepared patient’s files. Results: The frequency of primary and secondary infertility among women was 62.97% and 37.03%, respectively. Among 370 couples, 35.68% had female factor, 29.46% had both male and female factors, and 19.73% had male factor, while 15.14% of the couples had unexplained infertility. Conclusion: Primary infertility was common health problem in couples, also the causes of infertility in women is noticed more than men.

Keywords

Infertility --- Etiology --- Hormones --- Semen


Article
Correlation of serum and seminal plasma human growth hormone concentration with semen parameters of normozoospermic and infertile men
علاقة تركيز هرمون النمو البشري في المصل والبلازما المنوية مع معايير المني للرجال سوي النطف والمصابين بالعقم

Author: محمد باقر محمد رشاد
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2011 Volume: 1 Issue: 2 Pages: 18-24
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

BackgroundBackground: Human growth hormone (HGH) is undisputedly a potent hormone with a wide variety of biological effects. The anabolic actions of human growth hormone have made it attractive as a potential agent forcatabdicproblems in a wide range of clinical conditions,QbjectiveI n the present study, we investigated the possible relationship between levels of H G H in serum (S. HGH) and seminal plasma (Sp. HGH) and semen parameters in normozoospermic (NZS) men and infertile patients.materials and methods:In total, 66 infertile patients with azoospermia (AZS; no. 52), asthenozoospermia [AsZS; no, 6) and oligoasthenoteratozoosperrriia (OATZS; no. 8), and normozoospermicmen (NZS; no. 12)were included in this study.. From each subject semen and blood samples were taken to assess seminal plasma and sperm para meters and levels of S. HG H and Sp. HG H; respectively.resultsThe highest 5. HGH was evaluated in AZS patients when compared to NZS and other infertile groups. Significant elevation {P<0.05) in the level of S. HGH was assessed for AZS patents as compared to NZS men. in contrast the level of Sp. HGH in NZS men was significantly elevated (P<0 Q5)when compared to AZS patients only. Positive and significant correlations were noticed between levels of Sp. HGH and semen liquefaction time in NZS, AZS and OATZS groups, in NZS men, positive and significant correlation were observed between Sp. HGH and semen volume and negative and significant correlations were detected between Sp. HGH and percentages of sperm motility, progressive motility, immobility and agglutination.conclusionOur study represents the first study in Iraq showing that the level of HGH in serum and seminal plasma affect male fertility and sperm parameters in normozoaspermic males and infertile patients. Further biochemical and molecular studies are recommended to investigate the mode of action of HGH and its receptors in relation to fertility.


Article
Effect of adding Cinnamomum camphora on the testosterone hormone and reproductive traits of the Awassi rams

Author: Tamara N. Dawood
Journal: Kufa Journal For Veterinary Medical Sciences مجلة الكوفة للعلوم الطبية البيطرية ISSN: 20779798 Year: 2014 Volume: 5 Issue: 2 Pages: 36-45
Publisher: University of Kufa جامعة الكوفة

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Abstract

This study was aimed to find out the effect of camphor on sexual behavior in male rams. Eight sexually mature Awassi rams were randomly divided into two groups, the experimental group was received Cinnamomum camphora (20 mg/kg/ day) orally with their concentrated diet for four weeks; while the other group (control) were feed on the same diet without adding camphor. Semen was collected from the rams and the results showed that camphor reduced the semen volume, mass activity, testes length and live sperm percentage while there were insignificant differences in the testes circumference, semen concentration, individual motility and testosterone hormone level between the treated and control groups. In addition it was noticed that the abnormal percentage of sperm was significantly higher in camphor group compared with the control group.

Keywords

testosterone --- Awassi rams --- Semen --- camphor


Article
Effects of Metformin on Sperm Parameters in Mice: as a model for human being

Authors: Muhammad –Baqir M-R Fakhrildin --- Mohammad 0. Selman --- Ahmed. Kh. Rashid
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2016 Volume: 6 Issue: 1 Pages: 45-60
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Metformin is anti-hyperglycemic effect due to decrease of hepatic glucose production. Another effect, leading decrease insulin resistance, regarded a safe drug, treatment of choice for overweight.Objective:To investigate the effects of 3 concentration of MF administered orally to male mice on sperm parameters as model for human being.Materials and Methods:In current study, 80 male mice were taken with age ranging between 1.5-2 month and weights ranging between 25-30 grams males classified into four groups of a control group (G1) and treated group (G2, G3 and G4) doses of MF were employed, 0.2, 0.4, 0.6 mg/mice daily to groups, given orally for 6 weeks and then the animals were scarified.ResultsResults have revealed a significant difference (P < 0.05) in sperm concentration for 3 groups compared to G1 group. Progressive motility (%) appeared with significant difference (P< 0.05) for G3 group as compared to other treated and G1 group. Furthermore, the result illustrated a significant decreased (P< 0.05) in the abnormal sperm morphology for G3 group compared with treated and control. However, sperm agglutination (%) confirmed that the G3 group exhibited highly statistical significant decrease (p≤0.001) compared to G1, G2 and G4.ConclusionsFrom results of the present study, it was concluded that the administration of MF doses reduce sperm concentration .while, 0.4mg dose improve certain sperm parameters.


Article
The effect of treatment by L-carnitine for infertile men on semen parameters
تأثير الكارنتين في علاج الرجال العقيمين

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Abstract

L-Carnitine (LC) is highly concentrated in the epididymis and plays a crucial role in sperm metabolism and maturation.They are related to sperm motility and have antioxidant properties. The objective of this review is to summarize the multiple roles played by LC in male reproduction, and to highlight their limitations as well as their benefits in the treatment of male infertility. A variety of studies support the conclusion that LC at total daily amounts of at least 500mg per day can significantly improve both sperm concentration and total sperm counts among men with astheno – or oligoasthenozoospermia. Although many clinical trials have demonstrated the beneficial effects of LC in selected cases of male infertility. Additional, a well – designed study is necessary to further validate the use of carnitines in the treatment of patients with male infertility, specifically in men with poor semen quality .

(الكارنتين) يتركز بشدة في البربخ ويلعب دورا حاسما في استقلاب الحيوانات المنوية والنضج.ترتبط بحركة الحيوانات المنوية ولها خصائص مضادة للأكسدة. الهدف من هذه المراجعة هو تلخيص الأدوار المتعددة التي تلعبها الكارنتين في إعادة إنتاج الذكور، وإبراز دورها وكذلك فوائدها في علاج العقم عند الذكور. تدعم مجموعة متنوعة من الدراسات الاستنتاج القائل بأن الكارنتين الكميات اليومية التي تستخدمها الشخص والتي لا تقل عن 500 ملغ في اليوم يمكن أن يحسن بشكل كبير كل من تركيز الحيوانات المنوية وعدد الحيوانات المنوية الكلي لدى الرجال المصابين بالوهن أو قلة في عدد الحيامن. على الرغم من أن العديد من التجارب السريرية قد أثبتت الآثار المفيدة لي الكارنتين في حالات معينه ومختارة من العقم عند الذكور، إضافية، دراسة مصممة بشكل جيد ضروري لمزيد من التحقق من صحة استخدام الكارنتين في علاج المرضى الذين يعانون من العقم عند الذكور، وخاصة في الرجال الذين يعانون من نوعية السائل المنوي الفقيرة ( قليلة في العدد والنشاط).


Article
EFFECT OF AQUEOUS EXTRACT OF TURMERIC ON PATHOGENIC BACTERIA ISOLATED FROM SEMEN IN A SAMPLE OF IRAQI INFERTILE MEN

Author: Rehab Sh Al-Maliki رحاب شفيق المالكي
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2012 Volume: 10 Issue: 2 Pages: 105-110
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Contamination of semen with sexually and none sexually transmitted bacteria plays an important role in male infertility, contaminating bacteria should be eradicated by antibiotics, but most of bacteria become resistant to available antibiotics. Therefore most researchers search to find other antibacterial agents.Objective: To evaluate the frequency of bacteria in semen of infertile men and investigate the antibacterial activity of aqueous extract of turmeric (AET) on certain isolated bacteria from semen of infertile men compared with that of doxycycline as a standard antibiotic.Methods: Forty two semen samples obtained from infertile men attending The Higher Institute of Infertility Treatment and Assisted Reproductive Technology were evaluated bacteriologically using standard bacterial culture. Then investigated the antibacterial activity of AET on certain isolated bacteria from semen of infertile men compared with doxycycline using disc diffusion method.Results: Out of 42 semen samples of infertile men, 35(83.03%) were infected with different bacterial species (spp.) accompained with highest incidence rate. The overall frequency of N.gonorrhea and S.epidermides was 8(19%) and for remaining bacterial isolated from semen (S.aureus, G.vaginalis and E.coli) were 6(14.28%). Comparable antibacterial activity of ATE and doxycycline was found to be evident against most isolated bacteria (P<0.001) in mean inhibition zones of AET between Gram’s positive and Gram’s negative bacteria (23.35±0.68 and 8.35±1.52, respectively).Conclusion: Most of isolated bacteria from semen of infertile males had high frequency, which were generally accepted as pathogenic bacteria. Antibacterial activity of AET was comparable with doxycycline against most isolated bacteria and it was found more effective on Gram’s positive than Gram’s negative bacteria.Keywords: Turmeric, pathogenic bacteria, semen, infertile men


Article
Oral imipramine and intravenous xylazine for pharmacologically-induced ejaculation in donkeys
إعطاء الامبرامين عن طريق الفم مع الزيلازين عن طريق الوريد لإحداث القذف دوائيا في الحمير

Authors: U.T. Naoman عدي طلعت نعمان --- A.J. Ali علي جدعان علي
Journal: Iraqi Journal of Veterinary Sciences المجلة العراقية للعلوم البيطرية ISSN: 16073894 Year: 2012 Volume: 26 Issue: 2 Pages: 81-83
Publisher: Mosul University جامعة الموصل

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Abstract

The aim of this study is to evaluate using chemical method by oral imipramine and intravenous injection of xylazine for semen collection from donkeys in a field condition. Five mature male donkeys were used in this study weighting 120-150 Kg, aged 2-4 years, kept in the animal house of the Veterinary Collage, University of Mosul. Semen collections were performed by administration of a combination of imipramine hydrochloride 3 mg/kg. BW orally then 2 hours later, intravenous xylazine hydrochloride was injection as 1.1 mg/kg BW then semen was collected in ballistic tube. A total of 29 ejaculates from 30 trials were collected successful with a successful rate up to 96.6%. Semen characteristics of these donkeys were volume 60.1±2.9 ml, individual motility 53.5±2.0%, sperm concentration 60.2±1.7×106/ml sperm abnormalities 9.5±3.3%, live sperm 57.2±4.5% and PH 7.3±1.8. It could be concluded that, chemical method could be used successfully for semen collection from donkeys.

اجريت الدراسة الحالية لغرض تقييم الطريقة الكميائية التي تضمنت اعطاء الامبرامين عن طريق الفم ثم حقن الزايلازين عن طريق الوريد لغرض جمع السائل المنوي في الحمير في ظروف الحقل، استخدم في الدراسة خمسة ذكور حمير بالغة تراوحت اوزانها مابين 120-150 كغم، وكانت اعمارها مابين 2-4 سنوات، وضعت الحيوانات في بيت الحيوان التابع لكلية الطب البيطري، جامعة الموصل. جمع السائل المنوي بعد اعطاء الامبرامين عن طريق الفم بجرعة 3 ملغم/كغم من وزن الجسم ثم حقن الزايلازين عن طريق الوريد بجرعة 1,1 ملغ/ كغم من وزن الجسم، وبعد 2 ساعة، جمع السائل المنوي في انبوب جمع بلاستيكي استخدم لهذا الغرض، جمعت 29 قذفة منوية من مجموع 30 محاولة بنسبة نجاح بلغت 96,6٪، صفات السائل المنوي للحمير التي تضمنتها الدراسة كانت 60,1 ± 2,9 مل للحجم، 53,5 ± 3,3 ٪ معدل الحركة الفردية ، تركيز الحيامن بلغ 60,2 ± 1,7 × 610، تشوهات الحيامن بلغت 9,5 ±3,3٪ ،نسبة الحيامن الميتة 57,2 ±4,5 ٪ ومعدل الدالة الحامضية 7,3 ± 1,8. يستنتج من الدراسة الحالية انه بالامكان استخدام الطريقة الكميائية لغرض جمع السائل المنوي في الحمير.


Article
Effect of Ivermectin on semen parameters and levels of Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) enzymes in seminal plasma of Iraqi Awassi rams
تأثير الايفرمكتين على صفات السائل المنوي ومستوى أنزيمي الالنين ترانسفريز والاسبارتيت امينوترانسفريز في البلازما المنوية للكباش العواسية العراقية

Author: Ali. J. Ali علي جدعان علي
Journal: Al-Qadisiyah Journal of Veterinary Medicine Sciences مجلة القادسية لعلوم الطب البيطري ISSN: 18185746 23134429 Year: 2014 Volume: 13 Issue: 1 Pages: 115-119
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

The objective of this study was to evaluation the effect of Ivermectin on semen quality and estimation of alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in seminal plasma. Six mature Awassi rams aged 2-3 years and weighing 38-42 Kg were used in this study. Semen collection was done weekly for five weeks from the same ram. The first two collection was considers as training for the animal and discarded, the second two collection were considers for control group. After administration of the drug (Ivermectin), semen samples were collected from the Awassi ram 1, 7,14 days. The parameter studies were included semen volume, percentage motility of sperm, sperm concentration, live sperm, and morphology percentage. Samples of seminal plasma were analyzed for the estimation of alanine aminotransferase (ALT), aspartate aminotransferase (AST). Results of this study indicate that Ivermectin leads to significant (P<0.05) decreased in semen parameters after first semen collection. Reaction time significantly higher (P<0.05) in the treated group after 1 days of injection. Alanine aminotransferase ALT, Aspartate aminotransferase AST show no significant differences in activities in seminal plasma during study. In conclusion: it is preferable to use the animals for the purpose of reproduction only after at least 7 days after Ivermectin injection due to it harmful effect on semen quality.

الهدف من هذه الدراسة لغرض معرفة تأثير الايفرمكتين على صفات السائل المنوي ومستوى أنزيميِ ALTوAST في بلازما السائل المنوي وكذلك معرفة مدى تأثير الايفرمكتين على مستوى وقت التفاعل في الكباش. ست أكباش عواسية بالغة (تراوحت أعمارها ما بين 3-2 سنة وأوزانها ما بين 42-38 كغم) استخدمت في هذه الدراسة. جمع السائل المنوي منها كل أسبوع مرة واحدة لمدة 5اسابيع بطريقة المهبل الصناعي بعد ترك أول قذفتين لغرض التدريب . ثم حقنت الكباش بعقار الايفرمكتين تحت الجلد بجرعة 0.2 ملغم/كفم من وزن الجسم جمع السائل المنوي من الحيوانات بطريقة المهبل الصناعي بعد 14,7,1يوم تلت عملية الحقن، قيمت صفات السائل المنوي الحجم ، الحركة الجماعية، الحركة الفردية، نسبة الحيامن الحية، تركيز الحيامن، نسبة الحيامن المشوهة وتم جمع عينات من بلازما السائل المنوي لغرض قياس تركيز مستوى أنزيمي ASTوALT في بلازما السائل المنوي في كل وقت من أوقات جمع السائل المنوي وكذلك قياس مستوى وقت التفاعل أظهرت نتائج الدراسة انخفاضا معنويا (P<0.05) لصفات الحجم وتركيز الحيامن والحركة الجماعية والحركة الفردية ونسبة الحيامن الحية والمشوهة وعدم وجود فرق معني بين مستوى أنزيمي ASTو ALTفي بلازما السائل المنوي ، بينما لوحظ زيادة معنوية في مستوى وقت التفاعل بعد 1 يوم من حقن الايفرمكتين تحت الجلد، بعد 7 أيام من حقن الايفرمكتين لم يلاحظ وجود فروقات معنوية في صفات السائل المنوي ومستوى أنزيميAST و ALT قبل وبعد حقن عقار الايفرمكتين. يمكن الاستنتاج انه من غير المفضل استخدام الحيوانات لغرض التناسل الأبعد 7 أيام على الأقل من استخدام الايفرمكتين تأثيره الضار على صفات السائل المنوي ومستوى أنزيمي ASTو ALTوكذلك على وقت التفاعل.


Article
Possible Role of Biological Agent on Characteristics of Sperm in Patients with Spondiloarthritis

Author: Atta AH. Mousa
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2015 Volume: 8 Issue: 1 Pages: 44-48
Publisher: Diyala University جامعة ديالى

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Abstract

Background: The role of TNF-α and TNF-α antagonists on seminal fluid parameters in men is controversial. TNF-α is a cytokine had a wide range of cellular effects. In testis, “TNF-α is produced by germ cells and it has a role in the regulation of spermatogenesis”. Objective: to study the effect of biological agent on sperm quality in a group of spondyloarthritis patients Patients and Methods: A prospective study was carried out in Baghdad teaching hospital during the period starting on 1st of January 2013 till the end of October 2013 .All semen samples of (60) spondyloarthritis patients and controls (60) was collected by masturbation after (72) hour of sexual abstinence. The semen samples was examined with regard to sperm concentration, motility, and morphology, according to WHO 1999 guidelines.. Results were compared with controlsResults: According semen parameters such as Volume, PH, Count, Motility Morphology in two groups of spondyloarthritis there were no significant differences noticed between TNF blocking agents and semen parameters when compared to controls group on( baseline ) but after (40 weeks), Regarding motility and morphology significant differences (P<0.001) were found between cases and healthy controls.Conclusion: Biological agents (infliximab&enbrel) had no affect on seminal fluid parameters such as volume, PH and sperm concentration, but it decreased motility of sperm and percent of normal morphology

Keywords

Sperm --- Biological agent --- Semen --- arthritis --- TNF

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