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Article
A study on the Prevalence of Dyslipidemic Disorder Among Residents of Karbala City

Authors: Hedef Dhafir El-Yassin --- Zainab Abdul Razak Al- Sharifi --- Suhair Al-Jeboori
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 3 Pages: 358-366
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Dyslipidemia is a common health problem.OBJECTIVE:The present study was to estimate the prevalence of dyslipidemia as defined by the NCEP ATP3 criteria among people living in Karbala city.SUBJECTS AND METHODS:The investigations were performed on a sample of 130 subjects selected arbitrarily from those attending the public clinic in AL- Hussainy teaching hospital in Karbala for consultation and from some subjects accompanying the patients. Fasting blood samples for routine lipid analyses from each subject were obtained after informing them about the project and having their approval.RESULTS:In this sample of subjects it was found that 72.3% of them had a plasma TC level lower than 200mg/dl. This study also determined a prevalence of hypertriglyceridemias in 23.3% of study subjects who have a borderline TG level. The prevalence of high and very high TG among them were 6.9% and 4.4% respectively. The frequency of LDL-C levels above 160 mg/dl was found to be about 1% of the sample. Borderline levels of LDL-C was found in 7.3%of the sample. In the meantime the prevalence of low HDL-C levels in this study was found to be 39.2% of the subjects who had a serum level of HDL-C less than 40mg/dl.CONCLUSION:In conclusion this study demonstrated a very high prevalence of dyslipidemia among Iraqi adult subjects living in Karbala city. A public health strategy for prevention, detection and treatment of this disorder is neede


Article
Evaluation of Changes in Levels of Serum Selenium in Diabetic Pateints and in Diabetic Pateints with Cardiovascular Disease

Author: Khawla Abdul Kareem Kasar
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2011 Volume: 14 Issue: 2 Pages: 58-66
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

AbstractSelenium, an essential micronutrient, may affect several cardiometabolic risk factors, such as glucose homeostasis and lipid concentrations. The aim of this study is to examin the relation between serum selenium concentrations with serum lipids in diabetic patients and in diabetic patients with cardiovascular diseases (CVD).A case control study conducted in the National Diabetes Center, College of Medicine at Al-Mustansiryia University. Fasting glucose, total cholesterol, high density lipoprotein–cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), and very low density lipoprotein-cholesterol (VLDL-C), HbA1c and Serum selenium were determine. Diabetes mellitus (n=256) divided into tow groups, group I (n=156) diabetic patients and group II (n=100) diabetic patients complicated with CVD. Normal healthy subjects were taken as control (n= 100).In the present study a significant decrease in selenium levels was found in patients groups compared to control also there is decrease in selenium levels of diabetic patients with CVD (group II) compared with diabetic patients (group I). These findings indicate that the decrease in serum selenium was associated with elevated serum concentrations of fasting blood glucose, total cholesterol, LDL-C, VLDL-C, triacylglycerols and duration of diabetes. In general despite their classification according to sex or diabetes type highly negative correlations (p<0.0001) were found with linear regression equations between fasting serum selenium concentration and HbA1c in patients group II. In conclusion the significant reductions in the level of selenium in diabetic patients may be response on the developing t he diabetic to anther disease like CVD.

الخلاصةالسلنيم من العناصر المهمه في عمليات الاكسدة في الجسم و من العوامل المؤدية الى أمراض اخرى عند مرضى السكري ومن اهمها امراض القلب .لذالك اجريت هذه الدراسة في المركز الوطني لمرض داء السكري في كلية الطب-الجامعة المستنصرية وقد تم قياس مستوى عنصر السلنيم في مصل الدم لمرضى السكري (156) ومجموعة اخرى من مرضى السكري مصابون بامراض قلبية (100) ومقارنتهم بمجموعه ثالثة من الاصحاء (100) مع مراعت تقارب العمر والجنس بين المجموعتين من مرضى السكري ومجموعة الاصحاء. وبلاضافة الى عنصر السلنيم قد تم قياس كل من السكر الصائم والدهون ونسبة الهيموكلوبين.وقد اضهرت النتائج نقصان في مستوى عنصر السلنيم في المجموعتين من مرضى السكري مقارنتا بالاصحاء. وقد لوحضى ان مستوى عنصر السلنيم اقل في مرضى السكري المصابون بامراض قلبية (المجموعة الثانية) مقارنتا بمرضى السكري (الجموعة الاولى). وبغض النظر عن تقسيم المرضى المصابين بداء السكري (حسب الجنس ونوع الداء، وجدت علاقة خطية سالبة الارتباط عالية الاهمية بين مستوى عنصر السلنيم ونسبة هيموكلوبين الصائم (HbA1c) عند المرضى المصابين بداء السكري وامراض قلبية (المجموعة الثانية). بلاضافة الى ذلك لقد وجدة علاقة مهم بين مستوى عنصر السلنيم و كل من السكر الصائم و الكولسترول وTG والدهون قليلة الكثافة LDL في المجموعة الاولى. اما بالنسبة للمجموعة الثانية فقد وجد علاقة مهمة بين مستوى عنصر السلنيم و كل من السكر الصائم و الكولسترول. الاستنتاج من هذه الدراسة ان النقصان الملحوض في مستى عنصر السلنيم في مرضى السكري هو من اسباب تطور المرض واصابت المرضى بامراض اخرى من اهمها امراض القلب.


Article
Effects of simvastatin on lipid profile, atherogenic index and serum transaminases in hyperlipidemic patients
آثار سيمفاستاتين على البروتين الدهني ومؤشر تصلب الشرايين و مصل transaminases في مرضى شحميات الدم

Authors: Ari Aziz Salih --- Showan D. Husain
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2011 Volume: 15 Issue: 2 Pages: 29-33
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objectives: Hyperlipidemia is characterized by increased concentrations of lipids including triglycerides, total cholesterol, low density lipoproteins, very low density lipoproteins in the blood and some times decreased high density lipoproteins .Many drugs have been used for treatment of this disorder. The present study was designed to estimate the effects of simvastatin on lipid profile, atherogenic index, transaminases, creatinine, uric acid and alkaline phosphatase.Methods: This study covered 70 subjects, they were divided into two groups, the first group included 45 hyperlipidaemic patients which were treated with 20mg simvastatin and second group included 25 normal subjects. After 12 hours fasting, serum lipid profile, transaminases; alkaline phosphatase, uric acid and creatinine were measured for the patients in 3 intervals before treatment, after 8 weeks and 16 weeks of treatment, and one time for normal subjects.Results: : After therapy, simvastatin showed a significant reduction in serum (TC, TG, LDL, VLDL and atherogenic index) and also, significant rise in HDL noticed, by performing a comparison between the group before treatment, and groups after treatment.Serum ALT, AST and ALP were significantly increased but were still within normal levels.Insignificant effect was observed from serum creatinine, uric acid and also body mass index by performing a comparison between group before treatment and groups after treatment.Conclusions:Simvastatin was effective in controlling lipid profile and atherogenic index, with no significant abnormality in liver functions.


Article
The Association Between Leptin with Lipid Profile and Troponin in Acute Myocardial Infarction Patients

Authors: lmmmA Esmaeel Ibrahim --- Hadef Dhafer EL-Yassin --- Hamid Kareem Sachit AL-Janabi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 3 Pages: 332-338
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT :BACKGROUND:Fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipose tissue also serves as an important endocrine organ by producing hormones such as leptin, resistin, and the cytokine. Leptin is a protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Acute Myocardial Infarction (AMI), is the interruption of blood supply to part of the heart, causing some heart cells to die.OBJECTIVE:To investigate the levels of leptin and its effect on lipid profile level in Acute Myocardial Infarction.SUBJECTS AND METHODS:The study included 50 patients with Acute Myocardial Infarction and forty healthy subject as control group. leptin and lipid profile levels were measured.RESULTS:The levels of leptin were significantly elevated in female patients group with(p=0.002), in male patients group(p=0.018) and in total patients group (p=0.001), cholesterol and LDL-C were significantly elevated with (p<0.001), while HDL-C was significantly lower with (p<0.001), there was positive correlation between leptin with , cholesterol LDL-C, triglyceride and VLDL, and there was negative correlation between leptin with HDL in acute myocardial infarction patients.CONCLUSION:Leptin negatively correlated with HDL and positively correlated with triglyceride and LDL this relation make this hormone act as atherosclerotic factor.


Article
Level of Resistin in Acute Myocardial Infarction Patients and its Relation to Lipid profile and Cardic Troponin I

Authors: lmmmA Esmaeel Ibrahim --- Hadef Dhafer EL-Yassin --- Hamid Kareem Sachit AL-Janabi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 4 Pages: 430-435
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Inflammatory responses are involved in the initiation and progression of atherosclerotic plaques. Myocardial Infarction (MI) is most commonly due to occlusion of a coronary artery following the rupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue may play an important role in mediating this chronic inflammatory process. Resistin is a cysteine-rich polypeptide that is expressed at relatively lower levels in human adipocytes but higher levels in macrophages. Troponin is found in cardiac muscle and used for diagnosis of AMI.OBJECTIVE:To investigate the level of resistin and its effect on lipid profile and Troponin I levels in acute myocardial infarction patients.SUBJECT AND METHODS:The study included 50 patients with AMI and forty healthy subjects as control group. In this study resistin , lipid profile and Troponin I were measured.RESULTS:The levels of resistin, cholesterol, LDL-C were significantly elevated with (p<0.001), while HDL-C was significantly lower with (p<0.001), there was positive correlation between resistin with cholesterol, LDL-C, triglyceride and VLDL, while there was negative correlation between resistin with HDL in acute myocardial infarction.CONCLUSION:There was a significant increase in resistin level, in acute myocardial infarction patients and this increase may be related to inflammation. Resistin negatively correlated with HDL and positively correlated with triglyceride and LDL this relationship makes us consider this hormone as possible atherosclerotic factor


Article
Effects of metformin on the lipid profllein polycystic ovarian syndrome patients
تاثير عقار المتفورمين على مستوى الدهون عند مرضى متلازمه تكيس المبايض

Authors: طارق ناصر موسى --- منال طه العبيدي --- قيس احمد ابراهيم
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2011 Volume: 1 Issue: 2 Pages: 13-17
Publisher: Al-Nahrain University جامعة النهرين

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Polycystic ovary syndrome (PCOS) is (be most common and prevalent endocrinopathy in women , and the most common cause of anovulatory infertility- An altered lipid profile is common in polycystic ovary syndrome (PCOS) and is usually characterized by increased total cholesterol, triglycerides, low-density lipoproteins and very low density lipoprotein levels with low high-density lipoprotein. PCOS is associated wth a higher frequency of card Avascular disease because of dyslipidemia. Which are potent markers for cardiovascular risk factors. Metformin, is a widely used antihypenglycemic agent It decreases insulin resistance and reduces hyperglycemia through a reduction of the hepaticglucose production.ObjectivesDetermine Ihe beneficial effect of metformin in PCOS paliente in reducing lipid profile and subsequently reduction incardiovasculardisease.HctbodMeasurements and anaiysis levels of total cholesterol, triglycerides, taw-density lipoproteins, very low density lipoprotein and high-density lipoprotein were samples collected at the Institute of embryo research and infertility treatment. Al-Nahnain Univereity, PCOS patients were recruited at the consultant clinic Patients: forty three women with PCOS were studied. Anthropometric data, Jipki profile, were evaluated, before oral metformffi (50Qmg'twioedaify}treatinent and aflerthree months of use.Patients with PCOS after oral metformin treatment, revealed a sign ificant lowering serum concentrations of totat cholesterol, triglyceride, taw-density lipoproteins and very low density Apoprotein and elevated high- density lipoprotein compared to before treatment.cdqcbttkmsdyslipidemia is common finding in PCOS women, in this study we found that the use of oral metformin tablets 500mg/ twioe daily fcrthree months will correct lipid profile level (cholesterol triglyceride, LDL, VLDL and HDL) which is considered as caidiovascular risk factors and this lead to reduce risk of cardiovascular diseases.


Article
Serum lipid profile in patients with primary fibromyalgia

Authors: Enas J.Kaoud ايناس جاسم --- Munaf S.Daoud مناف صالح --- Mohammed H. Alosami محمد حسن
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2011 Volume: 53 Issue: 1 Pages: 89-92
Publisher: Baghdad University جامعة بغداد

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