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Effect of Aspirin on Sperm Specification and Some Hematological Parameters in Male Albino White Rat
تــأثير الأسبرين على مواصفات النطف وبعض قياسات الدم في ذكور الجرذان البيضـاء

Author: Bilal S. D. Al-Taei بلال سالم داؤد الطائي
Journal: Jornal of Biotechnology Research Center مجلة مركز بحوث التقنيات الاحيائية ISSN: 18151140 Year: 2014 Volume: 8 Issue: 4 Pages: 34-38
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Thirty male albino rats were divided into three groups, the first group was given aspirin at a dose of 25 mg / kg orally and twice a day, the second group dosage was 125 mg / kg at the same way, the third set group which considered as control was treated with physiological saline, each group took 0.5 ml amount. The period of experience took four weeks at the end of the experience, in the day 29the animals were anesthetized and eradicated the epididym is and calculated the total number of sperm and percentages of viable and dead sperm as well as the percentages of motile and non-motile sperm, the blood was taken for hematological tests, results confirmed the existence of a decreased significant value (P<0.01) in the total number of sperm of the 2nd group compared with control group and the decline value was less significant (p<0.05) in the first group compared with control group. In addition a significant value (P<0.01) increased in the percentage of dead sperm and non-motile sperm, also a significant value (p <0.01) decreased in the percentage of viable sperm and motile sperm, while the results proved the existence of a significant value (p<0.05) reductions in PCV, Hb, TWBC and monocyte values compared with control group. effect of aspirin on the male reproductive system may be due to being a Prostaglandins inhibitor, and These findings probably indicate that aspirin have deleterious effect on the blood chemistry of male albino rats.

قسمت ثلاثين من ذكور الجرذان البيض البالغة الى ثلاثة مجاميع, أعطيت المجموعه الأولى الأسبرين بجرعة 25 ملغم/ كغم عن طريق الفم ولمرتين يوميا أما المجموعه الثانيه فتم تجريعها بجرعة 125 ملغم / كغم بنفس الطريقه في حين أعتبرت المجموعه الثالثه مجموعة سيطره وتم تجريعها بالمحلول الفسلجي, كان حجم المحلول المجرع هو 0.5مل لكل مجموعه. استمرت فترة التجربه على مدى أربعة أسابيع وفي نهاية التجربه , في اليوم 29 خدرت الحيوانات واستأصل البربخ و حسب العدد الكلي للنطف والنسب المئويه للنطف الحيه والميته أضافه الى النسب المئويه للنطف المتحركه وغير المتحركه , وسحب الدم لاجراء الفحوصات الهيماتولوجية. أثبتت النتائج وجود أنخفاض معنوي (P<0.01 ) في العدد الكلي للنطف في المجموعه الثانيه مقارنة مع مجموعة السيطره وكان هذا الأنخفاض أقل معنويا في المجموعه الأولى مقارنة مع مجموعة السيطره (p<0.05)أضافه الى حصول ارتفاع معنوي(P<0.01) في نسب النطف الميته وغير المتحركه وأنخفاض معنوي في نسب النطف الحيه والمتحركه , كما واثبتت النتائج وجود انخفاض معنوي (P<0.05 ) في مستوى خلايا الدم الحمراء, وخضاب الدم و كريات الدم البيضاء الكلي و احادية النواة مقارنة بمجموعة السيطرة. ربما يعود تأثير الاسبرين على الجهاز التناسلي الذكري الى كونه مثبط للبروستوكلاندين ويستدل من هذا البحث على ان الأسبرين له تأثير على كيميائية الدم.


Article
ROLE OF VITAMIN E, L-CARNITINE AND MELATONIN IN MANAGEMENT OF Β-THALASSEMIA MAJOR

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Abstract

Background:β-thalassemia major is an inherited disease resulting from decrease or total lack of β globin chains. Patients with this disease need repeated blood transfusion for survival. This may cause oxidative stress and tissue injury due to iron overload and depletion of antioxidant enzymes.Objective:Evaluation the role of vitamin E, L- carnitine and melatonin supplementation in management of β-thalassemia major patients.Methods:Forty five patients with β-thalassemia major were allocated to three groups A, B and C treated with vitamin E, L-carnitine and melatonin respectively. Serum malondialdehyde, serum reduced glutathione, serum ferritin, Hb, PCV, MCV, MCH, and MCHC levels and RBCs count were measured before and after treatment.Results:A significant decrease was observed in serum malondialdehyde and ferritin level after therapy in all treated groups; whereas, no significant (P > 0.05) changes in glutathione level after treatment in all groups. Hb level and RBC count increased significantly in group A (vitamin E), whereas, PCV, MCV, MCH and MCHC levels did not change significantly in all treated groups.Conclusion:Vitamin E, L- carnitine and melatonin have beneficial effects of in reducing lipid peroxidation and iron overload in patients with β-thalassemia major. These antioxidants may increase the life span of RBCs, which manifested by significant increase in Hb level in vitamin E treated group and significant decrease in serum ferritin level in all treated groups.Keywords:Beta-thalassemia, malondialdehyde, glutathione, ferritin, hematological parameters, vitamin E, L- carnitine, melatonin.

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