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Article
Tumor Suppressor Gene( E-Cadherin )and Its Role in Normal and Malignant Cells

Author: Ali Hassan Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 3-4 Pages: i-xiii
Publisher: Babylon University جامعة بابل

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Abstract

Tumor suppressor genes (E-cadherin) are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact. Loss of E-cadherin-mediated-adhesion characterises the transition from benign lesions to invasive, metastatic cancer. Nevertheless, there is evidence that E-cadherins may also play a role in the wnt signal transduction pathway, together with other key molecules involved in it, such as beta-catenins and adenomatous poliposis coli gene products. The structure and function of E-cadherin, gene and protein, in normal as well as in tumor cells are reviewed in this paper.

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Article
Evaluation of Abnormal Cervical Cytology

Author: Ali Hassan Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 2 Pages: 117-123
Publisher: Babylon University جامعة بابل

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Abstract

The indicated clinicat evaluation of ar)?ical squamous cells demonstrated on papanicolaou(Pap) smear has been determined. Although several repons and opinions suggest that these cells arc ofno particular significances, other studies have noted these cetls in instances of advanceal cervicaldysplasia.The Objective of the present srudy was to determine rhe prevalence of dysptasia in106 patients withrecent Pap smear demonstrating atypical squamoxs cell . the study was conducted during the period1998-2002 in the cyne€ologic Clinic at Hilla Hospitals and Deparrnent of parhotogy, BabylonUniversity, Babylon, IRAQ.Abnomal colposopy was present in 59 (55%).ln 21 (36%) ofrhe 59 parienrs, dysplasia was confirmedhistologically. Statistical significance was presenr in each ofthe groups lvith tissue sampling (arypicaland immaturc squamous metaplasia, koilocltoric aq,pia, and dysplasia) when ages were comparedwith the palients having nomal colposcopy. . Pap smear is a significant indicalor of ceryical pathology.Altholgh this Pap smear may not be rsgarded as dysplasia" neither shouid be ignored. Cotposcopy Jndbiopsy of any abnonmlity is recommended in all these patients. Two distinct pattems of initialcletection of cenical dysplasia were apparent.It is concluded that the atpical squamous cell Pap smear is a significant jnd;cator oi.cervicalpathology. Although this atpical Pap smear may not be regarded as dysplasia, neither shoutd beignored. Colposcopy and biopsy of any abnomaliry is recommended in atl tbese patients

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Article
Study of .Focal Arteritis of the Epididymis

Author: Ali Hassan Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 2 Pages: 207-211
Publisher: Babylon University جامعة بابل

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Abstract

Necrotising ateritis apparently confined to ono organ yet showing histological fearures similarto those seen in polyarteritis nodosa is now well recognised.To report foxl cases of apparently isolated arteritis ofthe epididymis in patients who have noclinical evidence of systemic disease.The clinical. Histological, and immunohistochemical features of foxl cases of appareltlyisolated arthdtis of the epidilmis are presented. The aetiology and pathogenesis of the conditton arediscussed. Immunoglobulin and complement w€re shown in in acute arlerial lesions, but this is notconclusive evidence that isolatated arteritis is eilher an immune compiex disease or a forme liuste ofpolyarteritis nodosa,It is impodant that any patients with histological evidence of necrotizing aferitis should havefull clinical, hematological, and biochemical investigations to exclude systemic disease because oftheclinical differences between polyartedtis nodosa and isolated arteritis

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Article
Morphometric and pathological Study of Urinary Bladder Carcinomas: Significance of Schistosomal Fibrosis

Authors: Ali Hassan Al-Timimi --- Mohammad Sabri Abdu-Razak
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 3-4 Pages: 275-285
Publisher: Babylon University جامعة بابل

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Abstract

Objective measurement of microscopic features has been advocated for decades as a method to make more reproducible and "scientific" the practice of histopathology, but it is only recently that technical advances in computing have rendered this procedure suitable for diagnostic and prognostic determinations in surgical pathology. Urinary bladder cancer is the third most common malignancy in Iraq. Heavy Schistosoma haematobium infection predisposes to bladder cancer which is usually of squamous cell type and accounts for about one quarter of deaths from this infection.We investigated the extent of fibrosis in forty urinary bladder carcinomas (15 Schistosomal associated SASCC and 25 Schistosomal non-associated transitional cell carcinoma SNATCC). The cases were subjected to quantitative assessment of their fibrosis by (1) colorimetric micromethod for collagen measurement (2) morphometric assessment of collagen by use of image analyzer. The results obtained by both methods showed that SASCC were more fibrogenic than SNATCC and displaying more desmoplasia. It is concluded that the total amount of collagen in addition to the distribution pattern of the fibrotic process in schistosomal cases around the newly formed blood vessel and lymphatic both play a role in determination of the unique behavior of such neoplasm.

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Article
Acute Appendicitis Clinico - pathological Study

Authors: Ali A. Al-katib --- Ali Hassan Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 2 Pages: 162-170
Publisher: Babylon University جامعة بابل

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Abstract

Acute appendicitis is one ofthe most comnon surgical emergencies in lbe world. The aim ofthe present prcject was to study the clinical presentations, pathological features and labomtory test ofacute appendicitis in Babylon province"IRAQ.A total of 2000 patients witl susp€cted acute appendicitis who urderwent surgery were included inthis prosp€clive study. Clinjcal history , detailed physical examination, pathological f€atures andlaboratory investigations were reviewed,The results showed in this study showed that 1240 patients (62%) had appendicitis, 320 patients(16%) of them had acute appendicitis with complications , and the remainiry 440 p^ties (22%)had nomal appendicitis . Right iliac fossa pain, naus€a and vomiting were seen in 85%of cases.Tachycardia, fever seen in 95% cases.Tondemess in the dght iiiac fossa and rebound tondemess were seen in 88% . The WBC count wasover 10.000. ilr 85%.the WBC count was sensitive and valuable test. Ultrasound examination found tobe low sensitivity. ceneral urine examihation was not valuable in the diagnosis.It is concluded thar acute app€ndicitis is a condition, which requires immedjale $eatmenl. Thc use ofhighly sensitive tests favon the appropriaie diagnosis and treatment and minimizes the risk ofmissingacure infection cases

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