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Article
Tumor suppressor gene( E-cadherin )and its role in normal and Malignant cells (Part Two)

Author: Ali Hassan AL-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 1 Pages: VIII-XII
Publisher: Babylon University جامعة بابل

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Abstract

Progressive accumulation of somatic mutations in a number of different genes characterizes the process of tumorigenesis. Many genes involved in the process of tumorigenesis are components of one of a great many signal transduction pathways through which signals traffic via molecular networks. It is now apparent that epithelial malignancy can in certain aspects be explained by alterations in the adhesive properties of neoplastic cells.

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Article
Study of Cytokeratins Markers in Breast Carcinomas

Author: Ali Hassan AL–Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 1 Pages: 105-113
Publisher: Babylon University جامعة بابل

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Abstract

While several prognostic factors have been identified in breast carcinoma, the clinical outcome remains hard to predict for individual patients. Better predictive markers are needed to help guide difficult treatment decisions. In previous studies of breast carcinoma specimens, an association between poor clinical outcome and the expression of cytokeratin markers 17 and/or cytokeratin 5 mRNAs was noted. Here we describe the results of immunohistochemistry studies using monoclonal antibodies against these markers to analyze 55 paraffin-embedded breast tumors. We found that expression of cytokeratin markers 17 and/or cytokeratin 5/6 in tumor cells was associated with a poor clinical outcome. Moreover, multivariate analysis showed that in node-negative breast carcinoma, expression of these cytokeratins markers were a prognostic factors independent of tumor size and tumor grade.

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Article
Immunohistochemical Detection of MDA –DNA Adducts in Oral Mucosa of Smokers and Nonsmokers

Authors: Ali Hassan AL–Timimi --- Raad Ali Jassim
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 2 Pages: 150-157
Publisher: Babylon University جامعة بابل

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Abstract

Malondialdehyde (MDA) is a major lipid peroxidation product that is mutagenic and tumorigenic. MDA-modified DNA adducts have been detected in animal and human tissues and may be a marker of human cancer risk. An immunohistochemical method, using a previously generated monoclonal antibody specific for MDA–DNA adducts, has been developed for the detection and quantification of DNA damage in human oral mucosa cells. The method was used initially on mice liver cells treated with and without MDA, and then applied to the detection of adducts in oral mucosa cells of smokers and non-smokers. Levels of DNA damage were elevated in 25 smokers (mean relative staining intensity 97 ± 41) compared with 25 age-, and sex-matched non-smokers (74 ± 17, P < 0.02). These results demonstrate that MDA–DNA adducts can be measured in single cells of human samples by an immunohistochemical method. This methodology provides a simple way to monitor MDA–DNA damage and should be useful for studies investigating the role of exogenous and endogenous agents in oxidative stress and carcinogenesis.

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Article
clinico-pathological study of leukoplakia in babylon
داء الابيضاض الفموي ( الطلوان) دراسة سريرية مرضية

Authors: Raad Ali Jassim --- Ali Hassan AL- Timimi
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2005 Volume: 10 Issue: 4 Pages: 635-642
Publisher: Babylon University جامعة بابل

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Article
Cigarette Smoking and Lung Destruction Pathology: Nicotine Induces Leukocytes Chemotaxi

Authors: Fadhil Frhood M Algbori --- Ali Hassan Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 4 Pages: 388-396
Publisher: Babylon University جامعة بابل

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Abstract

lnflamnatory cells accunrulate within lhe lungs of cigareite smokeN. Cun€nt concepls suggesllhar drese cells can induce pfotease-antiproiease aDd/o. oxidant antioxidaDt inrbalance(s). which maydamage the nor al lung alveolar and inlerslitial structurcs. Because type 1l pneumocylcs line the alveolafsDace, and because lhe inflammatory cells migrale and rcside at the alveolus, we believcd thal the type IIpneumocytes nighl felease chenrotaclic aciivity for neutrophils and monocytes in responsc. To test thhhypolhesis, type II pneumocytes cells dissected 60 rat lung were exposed to smoke exlract and thesupe.natant fluids were evaluated for the neutrophil and monocyte chemotaciic activity (NCA and MCA)by a blnrd'well chamber technique. The results demonshate that the alveolaf epithelial like cell. rcleasedNCA and MCA in response to smoke extract in a dose- and time'dependent marner (P < 0.05).Checkefboad analysis showed that the activity was chemotaclic. Lipoxygenase inhibiro$ andcyclohexinride nnribited the release of NCA and MCA. Molecul sieve colunn chromatog|aphy showcdmuhiDle peaks tor both NCA and MCA. lt is concluded that The cigarelte smoke can inactivate aDtiproteaseprotection, thus cigaretie srnoke may lnfluence both rnatrix damage and repair processes, ieading to hngdestruction by inflamnratory pfocesse

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Article
Clinical Analysis and prognostic Significance of the Methyguanine Methyltransferase in Gastric Colorectal and Breast Cancer

Authors: Ali A. Al-katib --- Ali Hassan Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 4 Pages: 444-453
Publisher: Babylon University جامعة بابل

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Abstract

Methyl guariine nethyllmnsferase (MGMT) is an enzyme that repairs methyl guanine apromutagenic base damaged by endogenous and environmental alkyl ling agents The expression ofMCMT was immunohistochemically evaluated in 62,53, and 46 paEflin-embedded sa$ples frompatienB with respected grcup 4 gastfic colorcctal and breast cancen respectively theResults showed that the exprcssion of MGMT was positive prediciive factor for overall suNival ingastfic canceE (p <.001) and fof relapse-ftee survival in brcast cancers(p< 00l)MGMTposkive gastfictumo|s (n:42) wcrc correlaled with the absonce of serial invasion (p-045)lvmph Dode meriask(p=006) intestinal type (p=018) and low pathological tumor node metastasis stage (p<001) all breasttumon that rcconed locally al1ef operation were MCMT regalive (p=004) the disease crileria's ofcolofectal canceN with rcspect 1o MGMT expression did not sigDificantly differ 'lt is conchded thatLhe expfession of MGMT is a predicrive pfognostic markef iD patients with gastric and hreastcarreen .these findings may help 10 establisfi therapeutic stmtegies for palicnts lvilh lhesetypes of solid cancer

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Article
study of malignant diseases in babylon province the period 1990-1999
دراسة الاورام الخبيثة لمرضى الاورام في الفرات الاوسط المسجلة في محافظة بابل 1990-1999

Authors: Sheriff F. AL- Alawachi --- Ali Hassan Al- Timimi
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2005 Volume: 10 Issue: 4 Pages: 658-669
Publisher: Babylon University جامعة بابل

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Article
throbocytopathic purpura associated with eosinophilia
فرفرية اعتلال الصفيحات الدموية المصاحب لكثرة الحمضيات

Authors: Ali Hassan AL- Timimi --- Abbas Naji AL- Sharifi
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2005 Volume: 10 Issue: 4 Pages: 690-698
Publisher: Babylon University جامعة بابل

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