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Laryngeal Carcinoma: Prognostic Index and Evaluation of Treatment Results

Authors: Ali Hassan Al-Timimi --- Safa Sahib Naji
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2006 Volume: 3 Issue: 1-2 Pages: 81-87
Publisher: Babylon University جامعة بابل

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Abstract

Carcinoma of the larynx Constitutes 1.5% of all cancers and 25% of head and neck cancer. It is etiologically related to tobacco smoking, alcohol overuse, nutritional deficiency, human papilloma virus infection and environmental pollution. The aims of the present research was to study the Prognostic Index in Laryngeal carcinoma including age, sex, clinical manifestation, histological types, and to evaluation and correlated with treatment results . 165 consecutive patients with laryngeal carcinoma who were diagnosed, treated, and / or followed at Hilla hospitals during the period (1990-2004) were studied. The total number of patient diagnosed with laryngeal Carcinoma were 165 during the fourteen years period, 129(78%)patients were males 36 (22%) were females . M: F ratio was 3.58:1. 52% of patients were between 50 and 60 years of age. There were 3 patients with carcinoma insitu (2%), (13%) in stage1, (35%) in stage 2,(35%) in stage 3 and (15%) stage 4 . Of 165 patients, 102 (62%) were treated surgically followed by radiotherapy (group 1), 35 patients (21%) treated surgically followed by Radiotherapy and chemotherapy (group 2), and 28 patients (17%) were treated by surgery & conservative treatment (group 3). For patient in group (1) the one year survival rate was 68%, the 3 year survival rate was 38% and the 5 year survival rate was 15%, for group 2 the survival rate was 48%, 30% and 14% respectively, and for group 3 the survival rate was 28%, 10% and 4% respectively. We concluded that Laryngeal carcinoma in Babylon occurred at younger age group than the western reported studies and had low one , three & five years survival rate . Further studies are needed to confirm the risk factors involved in laryngeal carcinoma and to improve the health education toward its early detection and treatment.

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