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Interleukin-6 Level in serm of Iraqi Patients on MaintenanceHemodialysis Therapy

Authors: Asma Y.AI-Tharb** --- Kismat M. Turki * --- Hind H. Abdul Wahid
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 4 Pages: 431-434
Publisher: Baghdad University جامعة بغداد

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Abstract

Back ground : Chronic renal failure (CRF) is characterized by progressive destruction of renal mass with irreversible sclerosis and loss of nephrons over a period of at least months to many years which is treated either by dialysis which includes hemodialysis (HD) and peritoneal dialysis (PD) or renal transplantation.
Objective : To document the elevation of interleukin-6 (IL-6) in Iraqi HD patients, and to what degree that elevation influences secretion of C-reactive protein (CRP), in addition to its association with other acute phase proteins and kidney function tests .
Method : A total of 75 individuals were included in the present study, 50 individuals were treated with HD compared to 25 healthy volunteers.
Result : The level of serum IL-6 showed a significant increase in HD patients , and this elevation lead to a high increase in the secretion of CRP as well as the differences in levels of other serum acute phase proteins; ferritin revealed an increase in its level , while alb shows a decrease in its level . Kidney function tests were detected in sera of all the studied groups, which showed an increase in urea and Cr with a decrease in CrCI in patients group.

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