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Effect of chlorpromazine on intact and irradiated aliquot

Authors: Mohammad A. ALhamdany* --- Marwan S.M. Al-Nimer --- Ali M. Abbed*
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 157-161
Publisher: Baghdad University جامعة بغداد

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Abstract

Bagkground:Chlorpromazine is widely used in human medicine in the therapy of schizophrenia,organic psychosis and the manic phase of manic depressive illness. It expressed a selectivecytotoxicity and the results of genotoxicity were positive.Objectives: This study is designed to explore the effect of chlorpromazine on irradiated and nonirradiated calf thymus double strands DNA (ctdsDNA) molecule.Methods: Aliquots of irradiated (subjected to UVB light) and non-radiated ctdsDNA sampleswere incubatyed with different concentrations of chlorpromazine. Further series of experimentsstudied the simultaneous effects of chlorpromazine and UVB light on aliquots of ctdsDNA, Thechanges in optic densities of ctdsDNA aliquots were mointered and recorded bu UVspectrophotometerat 260 nm.Results: Chlorpromazine exerts dual effects on non-radiated ctdsDNA aliquots represented byhyperchromasia and hypochromasia in regard to its concentration. It potentiates the effect of UVBradiation on ctdsDNA molecules. Its effect is differed in respect to the radiation status.Conclusion: chlorpromazine exerts several effects on aliquot ctdsDNA samples which arerelated to the nature of DNA molecule as well as to the concentration of chlorpromazine.Alsochlorpromazine potentiates the hyperchromasic effect of UVB radiation on aliquot ctdsDNAsamples but it produces completely damage of DNA molecule when the aliquot ctdsDNA samplesirradiated in presence of chlorpromazine.

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