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Article
Age Related Changes in Cardiovascular Response to Oxidative Stress Induced by

Author: Affan E. Hassen
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 4 Pages: 495-503
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: There are many circulatory changes that occur during exercise in order to supply the tremendous blood flow required by the muscles during the stimulatory effects on circulation by the mass sympathetic discharge, the increased arterial pressure and cardiac output. The metabolic effects and the oxidative stress as a result of the work load on cardiac and skeletal muscles could also show changes. Objective: This study was designed to investigate the effects of aging process on the vascular response during exercise and also in the oxidative stress according to age. Subjects and Methods:Eight healthy Iraqi subjects were enrolled in this study. Divided into three groups according to age, group I (age range 20-29), group II (age range 30-39), and group III (age range 40-49). They were asked to exercise according to modified Bruce protocol. Blood samples were taken from each subject pre and post exercise for biochemical tests. The test included were creatine kinase, uric acid, malonedialdehyde (MDA) , lipid profile (triglycerides, cholesterol, high density lipoprotein HDL). Low density lipoprotein LDL was calculated. Results: There is a statistical significance increase in heart rate and systolic blood pressure after exercise in all groups however diastolic blood pressure showed a decrease. A positive linear correlation is present. Mean serum levels of uric acid was shown to be elevated after exercise, meanwhile triglycerides levels decreased significantly in all age groups after exercise and also cholesterol. LDL on the other hand showed a decrease in the younger age group. Conclusion: The results obtained set a normative data for the studied parameters for the age group included in the study to be used in the future for the detection and differentiation of any cardiovascular abnormality from age related changes. These data have important clinical implications if we are to prevent the frailty and morbidity associated with old age.


Article
Effect of Mode of Delivery on Maternal and Umbilical Cord Serum Lipid Profile

Author: Estabraq A.R.Kwaeri
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 3 Pages: 252-255
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Limited data are available with regard to the relation between maternal and fetal serum lipid and lipoprotein levels and the mode of delivery.The aim of this study is to evaluate the effect of mode of delivery on the levels of serum lipid and lipoprotein of mothers and their umbilical cords.METHOD:This study is consisted of fourty-nine pregnant women delivered by elective caesarean(CS)and seventy-five age-and gestational age-matched pregnant women who delivered by normal vaginal delivery(NVD).Serum lipid profile parameters including; total cholesterol(Tch),triglyceride(TG),high density lipoprotein-cholesterol(HDL-C) and low density lipoprotein-cholesterol(LDL-C)were measured in the serum of these two groups of pregnant women as well as in the serum of their umbilical cords.RESULTS:The mean(±SEM) values of serum Tch,TG,and LDL-C were significantly higher in pregnant women who delivered by NVD when compared with those of pregnant women delivered by CS(all P< 0.001).With regard to serum HDL-C mean value there was no significant difference between these two groups.Similarily,the mean (±SEM) values of serum Tch,TG,LDL-C were significantly increased in umbilical cord of NVD mothers in comparison with values obtained in umbilical cord of CS mothers( all P< 0.001).There was also a significant positive relationship between mothers and umbilical cord serum Tch levels in NVD group(r=0.339, P< 0.001).CONCLUSION:This study revealed that the mode of delivery ,in particular, NVD changes significantly the concentrations of lipid parameters mainly Tch,TG,and LDL-C.Such changes require an important attention postpartumly for such mothers with respect to biochemical investigation,particularly lipid parameters.


Article
Effect of Ramadan Fasting on Clinical Biochemical and Immunological Parameters in Healthy Fasting and Type Two Diabetes Mellitus Patients

Author: Majid M. Mahmmod Al-Jewari
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 4 Pages: 272-275
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Ramadan fasting is one of the pillaris of islam. The fasting time is about 12-19 hours depending on the season in which Ramadan falls and the geographic position of the country. It is often a subject of discussion nether or not Ramadan fasting confer any harmful effect on the body.OBJECTIVES:The aim of this study was to evaluate the effect of Ramadan fasting on some clinical, biochemical and Immunological aspects of the healthy and type two Diabetes mellitus patients.METHODS:The study was performed on (30) healthy fasting and (30) patients with type two diabetes mellitus in the month of Ramadan (2005). Blood samples were obtained on the second and fourth week's of Ramadan and were analyzed for fasting blood sugar, urea, uric acid, lipid profile, Immunoglobulins and complement component concentration, in addition, lymphocyte was separated to study the lymphocyte transformation assay in vitro compared with healthy non-fasting.RESULTS:There was slight elevation in the HDL-C, B. urea, S. Triglyceride, VLDL, S. uric acid and slight reduction in LDL-C at the end of fasting. There was slight reduction but the difference was non-significant (P>0.05) in the value of immunoglobulins (IgA, IgG, IgM) and (C3, C4) also, there was no difference in the sensitization rate of lymphocyte transformation in both healthy and type two diabetic patients compared with healthy non-fasting control.CONCLUSION:Slight elevation of HDL-C and slight elevation of B. urea, S. uric acid, S. Triglyceride, VLDL and there is non significant changes in Immunoglobulins and complement concentration and sensitization rate of lymphocyte transformation. Thus, Ramadan is safe for type two diabetic patients with the proper education of diabetic management.


Article
Population distribution of lipid profile
توزيع السكان من الدهون

Author: Amina Hamed Al – Obaidy امنة العبيدي
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2007 Volume: 1 Issue: 131 Pages: 84-90
Publisher: Tikrit University جامعة تكريت

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Abstract

Risk factors for coronary artery disease are now well recognized, and modification of these factors can prevent heart attacks. Therefore, a population based screening for lipid profile was conducted to determine the lipid abnormalities. A retrospective analytical study performed to determine the level of total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), and triglycerides in population and their values in relation to age and gender. The study indicated that the mean values of total cholesterol, LDL, HDL and triglyscerides were higher in male than female. In addition, the mean values were increased with age. The upper limit for cholesterol, LDL, and triglycerides were higher in male as compared to female, While the upper limit value for HDL was higher in female than in male. Although the mean values were within the reference interval, a 7.3% of individuals in younger age group demonstrated increased level of serum cholesterol. In conclusion, age and gender influence total cholesterol, LDL, HDL, and triglycerides level in Iraqi population. Thus it is recommended to implement screening for hyperlipidemia in all person twenty years of age and older. In addition, there is a need to establish a regional and national cholesterol education programs to act for detection, evaluation and treatment of high blood cholesterol in adults

والآن عوامل الخطر لمرض الشريان التاجي معترف بها بشكل جيد، وتعديل هذه العوامل يمكن أن تمنع النوبات القلبية. ولذلك، تم إجراء فحص السكان القائمة على الدهون لتحديد التشوهات الدهون. دراسة استعادية تحليلية أجريت لتحديد مستوى الكوليسترول الكلي (TC)، منخفض الكثافة (LDL)، وارتفاع الكثافة (HDL)، والدهون الثلاثية في مجال السكان وقيمهم فيما يتعلق السن والجنس. وأشارت الدراسة إلى أن متوسط ​​قيم الكوليسترول، LDL، HDL وtriglyscerides كانت أعلى في الذكور من الإناث. وبالإضافة إلى ذلك، تمت زيادة القيم المتوسطة مع التقدم في السن. الحد الأعلى لنسبة الكولسترول، والكولسترول، والدهون الثلاثية أعلى في الذكور مقارنة مع الإناث، في حين أن قيمة الحد الأعلى للHDL كانت أعلى في الإناث عنها في الذكور. على الرغم من أن متوسط ​​قيم كانت ضمن الفاصل الزمني مرجع، أظهرت 7.3٪ من الأفراد في الفئة العمرية الأصغر سنا زيادة مستوى الكولسترول في الدم. في الكولسترول تأثير الختام، العمر والجنس المجموع، LDL، HDL، والدهون الثلاثية في مستوى الشعب العراقي. وبالتالي فمن المستحسن لتنفيذ الكشف عن الدهون في جميع السنوات العشرين شخص من العمر وكبار السن. وبالإضافة إلى ذلك، هناك حاجة لتأسيس التعليم الكولسترول الإقليمية والبرامج الوطنية للعمل من أجل تقييم والكشف والعلاج من ارتفاع الكوليسترول في الدم لدى البالغين


Article
High Density Lipoprotein Cholesterol: A New Protective Function of Cardiac Structure and Function of Idiopathic Dilated Cardiomyopathy

Author: Basil O.M. Saleh
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 1 Pages: 49-53
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:There is a suggestion that abnormal coronary physiology may be exist early in the course of idiopathic dilated cardiomyopathy (IDC), and is likely to play an important role in the pathogenesis and progression of the myopathic state in such patients. With regard to lipid profile, high-density lipoprotein cholesterol (HDL-C) particle enhances NO production and improves endothelium relaxation.METHODS:This study included 50 patients aged 19-72 years (13 females and 37 males) with IDC and 23 healthy controls aged 29 to 60 years (9 females and 14 males). Lipid profile, should be at least 12 hours fasting, including serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) were evaluated in these two groups. Measurements of some of echocardiographic parameters including left ventricular (LV) systolic and diastolic diameters, and LV ejection fraction (LVEF) in IDC patients, and correlate its values with each one of the above lipid parameters in order to define the more predictor lipid parameter in evaluating the structure and function of the heart.RESULTS:The mean values of serum total cholesterol and LDL-C were insignificantly higher in patients with IDC patients than in controls. The mean of serum HDL-C was significantly low in IDC group against controls (P< 0.001). The mean (± SEM) serum triglyceride TG levels in patients with IDC was significantly increased when they were compared to that of normal controls (P< 0.05). An important inverse relation was observed between serum levels of HDL-cholesterol and LV diastolic diameter values (r= - 0.29, P< 0.039) as well as between HDL-cholesterol levels and LV systolic diameter values (r= - 0.33, P< 0.02). A borderline significant positive correlation between serum concentrations of HDL-cholesterol and the values of EF % was also shown in the IDC patients(r= 0.28, P< 0.05).CONCLUSION:The result of this study may point to the role of HDL-C in contribution to the LVdilatation and myocardial dysfunction (heart failure) in IDC.


Article
Introduction Of Biphasic Insulin Therapy For The Poorly Controlled Type 2 Diabetics Can Help In Achieving Recommended Glycemic Targets
أدخال الأنسولين ثنائي الطور في علاج مرضى السكري نمط ۲ ضعيفي السيطرة السكرية ممكن أن يساعد في أنجاز أهداف السيطرة السكرية الموصى بها

Authors: Tawfeeq F. R. AL-Auqbi د. توفيق فاخر العقبي --- Esam N. S. Al-Kirwi د. عصام نوري سلمان الكروي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2007 Volume: 20 Issue: 2 Pages: 319-324
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:Introduction: Insulin therapy in type 2 diabetes is either delayed or is suboptimal. Achieving intensive glycemic control will have the greatest benefits in patients with less advanced disease. OBJECTIVES: To demonstrate that introduction of biphasic insulin therapy can help in achieving stringent recommended glycemic control in poorly controlled diabetics. Methods: Six months prospective study on introduction of biphasic insulin instead of variable treatment modalities was carried out on 71 poorly controlled type 2 diabetics. Patients were interviewed three times, at the begining, after three and six months each time they were examined physically and investigated thoroughly. Results: Glycemic control parameters, glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) were investigated at the baseline , after three and six months. The parameters had shown a statistical significant reduction to meet the recommended glycemic control targets of the American Diabetes Association (ADA) and very close to the International Diabetes Federation, European Diabetes Policy Group (IDF). Lipid profiles were investigated at the beginning and after three months of the study. Total cholesterol, LDL-C and non-HDL-C were achieved statistical significant reduction. The triglyceride, VLDL-C, HDL-C and atherogenic index (TC/ HDL-C ratio) were reduced but the achievements were statistically insignificant. Conclusion: Biphasic insulin aspart progressively enable the poorly controlled type 2 diabetics to achieve the recommended glycemic targets. Achievements of the recommended targets reduce and/or normalize the lipid profile elements. Excellent results obtained can break down the patients and physicians barriers against use of insulin in type2 diabetes.Key Words: type 2 diabetes mellitus, biphasic insulin, glycemic control, lipid profile

الملخص: مقدمة: غالبا ما يكون علاج مرضى السكري نمط ۲ أما متأخرا او ليس بالمستوى الأمثل. أن الحصول على سيطرة سكرية دقيقة لها أعظم الأثر في صحة المرضى . هدف الدراسة: أثبات أن أدخال الأنسولين ثنائي الطور في معالجة مرضى السكري نمط ۲ ضعيفي السيطرة السكرية يساعد في أنجاز الأهداف السكرية الموصى بها عالميا. طريقة البحث: تم تصميم دراسة مستقبلية لستة اشهر تتضمن أستبدال أنماط العلاج الفموي المختلفة لمرضى السكري نمط ۲ بالأنسولين ثنائي الطور بواقع جرعتين يوميا. وقد أشترك 71 مريض مسجلين في المركز الوطني للسكري / الجامعة المستنصرية لهذا الغرض. تم متابعة المرضى وأجراء الفحوص المختبرية في ثلاث مراحل بداية الدراسة، منتصف الدراسة (بعد ثلاث اشهر) ، في نهاية الدراسة (بعد ستة اشهر) وتم في هذه الزيارات أجراء الفحص الطبي وأخذ عينات من الدم لفحص للفحص المختبري . النتائج: كانت معايير السيطرة السكرية في بداية الدراسة مرتفعة استمرت المعايير بالهبوط بعد استعمال الأنسولين ثنائي الطور و بدلالة احصائية واضحة؛ وقد حققت النتائج الأهداف السكرية المعلنة من قبل اتحاد السكري الأمريكي وقاربت لحد كبير الأهداف المعلنة من قبل الفدرالية العالمية للسكري والتي اعتمدت نتائج دراسة المجموعة الأوربية للسكري.. تم قياس الكولسترول ، الدهون الخفيفة و الدهون غير الثقيلة في بداية الدراسة وبعد ثلاث اشهر كان الأنخفاض انجازا ذو دلالة احصائية ؛ اما الدهون الثلاثية ، الدهون الخفيفة جدا ، الدهون الثقيلة ومعيار تصلب الشرايين فقد كانت النتائج بعد ثلاث اشهر قد حققت انخفاض بنسب انجاز غير ذات دلالة احصائية. الأستنتاجات: مكن الأنسولين ثنائي الطور بصورة مطردة مرضى السكري نمط 2 ضعيفي السيطرة السكرية من بلوغ الأهداف السكرية الموصى بها عالميا. كان للأنجازات التي حققها المرضى في بلوغ أهداف السيطرة السكرية الأثر الواضح في تقليل ومنع حدوث الوقعات و المضاعفات الخاصة بجهاز القلب والدوران لدى مرضى السكري نمط 2 وعملت على اعادة معدلات الدهون في الدم الى مستوياتها الطبيعية. أن النتائج الجيدة التي حققتها الدراسة تساعد في كسر الحواجز لدى المرضى والأطباء الخاصة باستخدام الأنسولين في معالجة مرضى السكري نمط 2.

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