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Article
Urine Cytology in Patients withLong Standing Dialysis

Authors: Liqaa R Mousa --- Mutaz A.Al-Qazzaz --- Yarub I Kattab
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2007 Volume: 4 Issue: 1 Pages: 1-4
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Dialysis is in common use to treat patients with end stage renal failure .However longstanding dialysis harboring some cellular changes in various body fluids. This study was conducted in order to detect these changes in urine.
Objective: The study was conducted to detect cellular changes in urine of patients with longstanding dialysis.
Method: Fifty-three urine samples were examined cytologically obtained from patients with longstanding dialysis during 6 months period. Freshly voided midstream urine samples were taken . Samples were centrifuged and 2 to 3 drops of sediments were smeared on 2 glass slides and fixed in 95% ethyl alcohol then stained with Hand E stain to be evaluated.
Results: Gross physical examination of all urine samples were neither purulent nor hemorrhagic .Microscopically there was increased exfoliation of urothelial cells except in 9 cases. No significant cytological atypia were seen in all urine samples. Excessive exfoliation in the absence of significant inflammation, hemorrhage and cytological atypia compared with control group.
Conclusion: The study revealed that some cytological changes do occur in the urothelial cells of patients with longstanding dialysis. These changes need further attention and study to disclose their causes.
Key words: Urine cytology, dialysis.

Keywords

Urine cytology --- dialysis


Article
An appraisal of urine cytology in the diagnosis of transitional cell carcinoma of the urinary bladder

Author: Tariq Mohamed Zeki * Msc (path) د. طارق محمد زكي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 2 Pages: 261-264
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:Background: Urine cytology has an acceptable sensitivity, & specificity that justifies its use in the current diagnostic protocol.In Iraq transitional cell carcinoma (TCC) constitute about 62.1 % of bladder cancer (which ranks the third according to the results of Iraqi Cancer Registry 1995-1997). Urine cytology used in the primarydiagnosis, follow up, and in the screening programs of asymptomatic but high-risk patients.Patients and methods: This study was conducted on 93 patients, diagnosed or clinically suspected to have TCC of the urinary bladder attending to the Urological department in AL- Kadhimiya Teaching Hospital, AL-Yarmouk Teaching Hospital, and Baghdad Medical City. During the period from July 2004to July 2005. 76 were males & 17 were females.Urine cytological examination was done to those patients using two types of stain (hematoxylin and eosin, and papanicoloau stain) to detect malignant cells with the identification of the degree of differentiation, if possible, the cytological findings were correlated with the histopathological findings. And the cytological findings compared regarding each type of stain.Results:. Mean age of the patients was 59 year. Male:female ratio was 4.4:1. Main clinical presentation was hematuria (45.8%) of the total.Urine cytological examination has a sensitivity of 87.7%, specificity of 100% with an overall accuracy of 78% in the detection of TCC of urinary bladder. The main chief complaint of patients with TCC was haematuriawitch constitute 45.8% of the total. The percentage of high¬grade cases in urine cytology was higher than that in histopathology.the percentage of cases of TCC diagnosed by papanicoloau stain was more than that diagnosed by H & E (73.24% by pap stain versus 70.42% by H&E).Conclusion: Urine cytology has an acceptable sensitivity, specificity and an overall accuracy in the diagnosis of TCC of urinary bladder, and it offers a good chance for determination of the grade of the tumor especially in high grade tumor. Pap stain was better in the diagnosis of TCC.Keywords: Urine cytology, bladder cancer,

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