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Article
Nucleolar organizer regions in giant cell lesions of the jaws in relation to clinico-pathological parameters

Author: Balkees T. Garib
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2008 Volume: 20 Issue: 2 Pages: 67-70
Publisher: Baghdad University جامعة بغداد

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Abstract

ABSTRACT
Background: The aim of this study was to clarify the proliferatiove activity of the multinucleated giant cells and cellular component in giant cell lesions of the jaw in correlation to their clinico-pathological features.
Materials and methods: This study was carried on 23 cases diagnosed as GC lesion of the jaw. Patient's personal and clinical information were collected from their files. H&E and sliver nitrate stains were applied on their formalin fixed paraffin embedded tissue sections.
Results: The mean AgNOR count in MGC/cell was 49.83 and NORs/nucleus was 5.8, and 74% of them were grouped in large clusters and 26% were scattered. In PGCG the mean AgNOR count /MGC and /nucleus were significantly lower than that of CGCL (38.2 vs 59.5 and 4.6 vs 6.8 respectively, P<0.04). The mean AgNOR count of spindle and mononuclear cells were 4.7 in CGC lesions and 2.5 in peripheral lesions
Conclusion: Evaluation of AgNORs showed that both MGC and fraction of mononuclear cells in CGCG were significantly higher than that in PGCG.
Key words: Giant cell lesion, nucleolar organizer. (J Bagh Coll Dentistry 2008; 20(2):67-70)

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Article
Immunohistochemical Coexpression of VEGF and CD34 in Ameloblastoma

Authors: Alaa G. Hussein* MSC (path), FICMS (path --- Balkees T.Garib --- wassan H. Younis
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2008 Volume: 50 Issue: 1 Pages: 42-49
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:Angiogenic potential m most tumors; characterized by VEGF and vascular bed densityaround tumor islands, is believed to be an important marker in predicting tumor growth,recurrence and metastasis.Materials and Methods:The study included 50 cases of ameloblastomas. From each case 4 μm sections werestained IHC with antivascular endothelial growth factor antibody- and endothelial linedvessels anti CD34 antibody to evaluate their expression and intensity in relation to theirFac Med Baghdad clinicopathological features.2008 ; Vol.50 ,No.Results:Generally, VEGF was significantly highly expressed with strong intensity in outer celllayer of tumor islands, and the newly formed blood vessels were significantlypredominantly rounded and small in size in comparison to dental folicale and papilla oftooth germ. Young aged patients (≤ 20yrs) had highest mean MvD around tumor islands(35.9). Regarding WHO classification; follicular, plexiform and lining cells in UAB hadhigher expression then acanthomatous and types, but 67% of those in plexiform were ofmoderate intensity. There was no significant differences in mean MvD in all histologicalsolid subtypes, and characterized by round and small vessels. Except those in plexiform,they were elongated and medium. UAB had significant lower microvessel count aroundlining tumor cells (but not around mural growth) and more percentage of elongated mediumsized vessels than follicular but less than plexiform. There was significant correlationbetween VEGF expression and the shape of microvessels. Considering differentmorphological cellular pattern, basal cells showed the highest VEGF positivity and intensity(87.5).1Received Sept. 2006Conclusions:The present study indicate the usefulness of the VEGF expression and MvD inexplaining the aggressive, locally invasive biological behavior of ameloblastoma. The highangiogenic potential is enhancing tumor cell survival and the increase in the production ofnew blood vessels formation is facilitating tumor growth, and by time will enhance theproliferation potential of the incompletely removed surviving tumor islands, so increasingthe chance of ameloblastoma recurrence.

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