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Article
frequency and significance of antibodies to asialoglycoprotein receptor in patients with autoimmune hepatitis

Author: Eman Sh. AL-Obeidy ايمان شاكر العبيدي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 1 Pages: 89-92
Publisher: Baghdad University جامعة بغداد

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Abstract

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Article
Evaluation of T- Helper (Th-1) Cytokines during the Treatment Responses of chronic Hepatitis C Virus

Authors: Eman Sh. AL- Obeidy --- Khalid A. Al-Khazraji
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 4 Pages: 464-466
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:It is widely assumed that cellular immune response and cytokine (especially proinflammatory cytokines) production play an important role in the course and treatment effectiveness of chronic hepatitis C infection.
Aim of the study: evaluate the level of Th-1 cytokines during treatment of chronic HCV infection and their dynamic changes in response to treatment.
Patients and methods: The study was performed on sixty patients with chronic HCV infection, the patients were recruited from medical city gastroenterology and hepatology teaching hospital for the period from February 2007 till February 2008 and 50 healthy control group. Diagnosis was made using third generation ELISA-based screening test, RIBA-based test and PCR-based test. On the other hand, Cytokines (serum level) were determined by ELISA method before, during (6, 12, 24 weeks) and after the treatment.
Results: This study showed that after 6 weeks from the initiation of the treatment by pegilated interferon-α in the combination with ribavirin, concentration of serum cytokines IL-1β, TNF- α and INF- γ have significantly changed and at the end of the treatment concentration of all cytokines have decreased and this change was statistically significant for all cytokines.Conclusion: dynamic changes of some cytokines during INF- α and ribavirin treatment may be used as a predictor factor for evaluation of the therapy effectiveness.


Article
Viruses as a Trigger for autoimmune Hepatitis in susceptible Individual

Authors: Bassim A. Asker --- Aswad H. Al.Obeidy --- Eman Sh. AL- Obeidy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 4 Pages: 471-474
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Autoimmune hepatitis (AIH) is a rare chronic liver disease of known etiology, characterized by hypergammaglobulinemia, characteristic auto antibodies, and a favorable response to immunosuppressive treatment.Strong circumstantial evidences denoted that there is quite long list of environmental factors such as (food additives and drugs), viruses and toxins which play an important role in precipitating this disease.
Patients and Methods: the study was performed on 13 Iraqi patients with acute viral hepatitis, attending the Teaching Hospital for Gastroenterology and Liver Disease and Al-Khadymia Teaching Hospital in the period between November 2003 and July 2005. ANA, SMA and anti-LKM 1 were detected by immunoflurescent technique whereas SLA/LP Ab was detected by Euroline method.
Results: the thirteen patients with acute viral hepatitis were developing AIH after 3 months.Conclusion: acute viral hepatitis is a trigger of AIH.

Keywords

Viral hepatitis --- AIH


Article
Correlation between some immunological parameters and clinicalpresentation in RA patients

Authors: Samira N. AL- Naim --- Eman Sh. AL- Obeidy --- Nahida R. Abbas*
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 2 Pages: 235-240
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Complement (C) & CRP in patients with Rheumatoid arthritis
(RA)'could be trigger disease activity.
Aim: To study the correlation between C, CRP, IgM,, IgG, IgA & some clinical
presentation in RA patients.
Methods: Latex agglutination test(AG) & single radial immunoassay(SRIA) were
used to asses CRP, IgMJgGJgA,, C, in 74 patients with RA.
Results: IgA & IgG were significantly increased, while the mean ofC3, C4 were
slightly elevated in RA patients .
Conclusion: There is correlation between IgG and IgM with joint deformity and joint
swelling respectively, while C3 was showed statistically significant P<0.01 with joint
stiffness, joint swelling and Rheumatoid nodule, where as CRP was statistically
significant P<0.01withjoint swelling.. Key words : RA.C.CRP, IgM, IgG, IgA, SRI A,
AG.

Introduction:

Rheumatoid arthritis (RA) is one of the
mysterious autoimmune diseases which is still
unresolved characterized by inflammation of
synovial membrane, principally affecting
peripheral joints in a symmetric fashion,
commonly leads to cartilage destruction, bone
erosion and joint deformities; extra-articular
manifestations such as vasculitis and
subcutaneous nodules can also occur, hence
it's course is quite variable (1 -3).

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Article
Anti-Liver membrane Antibody predict outcome of Autoimmune Hepatitis

Authors: Akram A. Najeeb --- Batool A. Al-Haidary --- Eman Sh. AL- Obeidy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 3 Pages: 395-399
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Autoantibodies against liver membrane are the specific
autoantibodies found in AIH. Cytochrome P450 1A2 has been identified as the
target autoantigen for these autoantibodies
The aim of the study : is to evaluate the prevalence and clinical relevance of
LMA in AIH
Methods: The study was performed on 73 Iraqi patients with chronic active hepatitis
(CAH) of unknown cause , attending the teaching hospital for gastroenterology and
liver disease in a period between November 2003 and July 2004. Anti-liver membrane
antibodies were studied by IFA technique.
Results: LMA was detected in the sera of 28(57.14)and 3(37.5%) patients with type 1
and type 3 AIH respectively, but never in the sera of healthy group .
Conclusion: It was concluded that LMA is present in type-1 and type-3 AIH but not in
sera of patients with type-2 or in healthy control group.

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