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Article
Effect of Volatile Oils of Some Medical Plants on the Blood Glucose and Cholesterol Levels in Mice
تأثير الزيوت الطيارة لبعض النباتات الطبية على مستوى كلوكوز الدم والكولسترول في الفئران

Author: H. K. Yaqob Al-Salman حيدر كاظم يعقوب السلمان
Journal: ANBAR JOURNAL OF AGRICULTURAL SCIENCES مجلة الأنبار للعلوم الزراعية ISSN: PISSN: 19927479 / EISSN: 26176211 Year: 2008 Volume: 6 Issue: 1 Pages: 284-295
Publisher: University of Anbar جامعة الانبار

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Abstract

The aims of This experiment were to study the effect of volatile oils from three types of plants which are: Nigella sativa, Foeniculum vulgare and Rosmarinus officinalis, They are well known medical plants and they are used commonly in traditional medicine.Volatile oils extracted by steam distillation. The biological activity studied In-vivo by oral administration of volatile oils into BALB / C male mice at doses of (0, 1, 2, 3, 4) mg / g BW for (7, 14, 21, 28) days.Serum glucose level was decreased by volatile oil of Nigella sativa at dose (2 mg/ g BW) or more. The blood glucose levels was (94.5 ± 1.24 mg/ 100 ml blood) as compared to control group (129.8 ± 0.98 mg/ 100 ml blood). No significant difference in glucose level was noticed between control group and group 3 and 4 at the treatment with volatile oil of Foeniculum vulgare and Rosmarinus officinalis respectively.The study showed that the volatile oil of Rosmarinus officinalis caused significant reduction in blood cholesterol level at dose of (3 and 4 mg/ g BW) for (14 days) or more. The cholesterol level was (134 ± 1.82 and 128.9 ± 2.32) mg/ 100 ml blood respectively as compared to control group (159.87 ± 0.91) mg/ 100 ml blood.

تهدف هذه التجربة الى معرفة تأثير الزيوت الطيارة لثلاثة أنواع من النباتات وهي نبات حبة البركة Nigella sativa ، نبات الشومر Foeniculum vulgare و نبات الحصالبان Rosmarinus officinalis وهي من النباتات الطبية المعروفة التي يشار الى امتلاكها خصائص علاجية في الطب الشعبي. استخلصت الزيوت الطيارة باستخدام طريقة التقطير البخاري. تم دراسة الفعالية البايولوجية داخل الجسم الحي In-Vivo ، عن طريق التجريع الفموي للزيوت الطيارة لذكور فئران بالب سي BALB / C male mice بالجرعات (صفر ، 1 ، 2 ، 3 ، 4) ملغم / غم من وزن الجسم لمدة (7 ، 14 ، 21 ، 28) يوما".تم تقدير مستوى الكلوكوز في مصل الدم ، ووجد أن الزيت الطيار لحبة البركة بالجرعة (2 ملغم/ غم من وزن الجسم) أو الأكثر منها أدت الى حدوث انخفاض معنوي في مستوى كلوكوز الدم (94.5±1.24 ملغم/ 100 مل من الدم) مقارنة بمجموعة السيطرة (129.8±0.98 ملغم/ 100 مل من الدم). لم تلاحظ أية اختلافات معنوية في مستويات كلوكوز الدم بين مجموعة السيطرة وبين المجموعة الثالثة والرابعة التي جرعت بزيت الشومر وزيت الحصالبان على التوالي.تم تقدير مستوى الكولسترول . أظهرت الدراسة أن الزيت الطيار للحصالبان سبب انخفاضا" معنويا في مستوى كولسترول الدم بالجرعتين (3 ، 4 ملغم/ غم من وزن الجسم) لمدة (14) يوما" أو أكثر، حيث كان مستوى الكولسترول (134±1.82 ، 128.9±2.32) ملغم/100 مل من الدم على التوالي، مقارنة بمجموعة السيطرة (159.87±0.91) ملغم/ 100 مل من الدم.


Article
Regeneration , Proliferation and Trans-differentiation of Adult Hepatic Oval Stem Cells into Functioning Beta-Cells and Exocrine Acinar Cells of the Pancreas in Diabetic Adult Rats

Authors: Maan H. AL-Khalisi --- Fadhil A. AL-Khafaji --- Zauhair A. Jaumah
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 4 Pages: 491-496
Publisher: Baghdad University جامعة بغداد

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Abstract

Back ground: Although adult stem cells possess plasticity that permit differentiation along newlineages, production of exocrine and endocrine pancreatic cells and insulin-secreting beta-cells fromadult non pancreatic stem cells has been considered controversial. We present that highly purifiedadult rat hepatic oval stem cells, which are capable of differentiation to hepatocytes and bile ductsepithelium, can also trans-differentiate into pancreatic exocrine-endocrine tissue, when homogenizedhepatic tissue is implanted into subcutaneous tissue .Methods and Materials: A total of 60 adult Swiss albino rats were divided into two groups . Group I, control group (30 animals) was injected with normal saline into the subcutaneous and pancreatictissue, group II (30 animals) has been exposed to 90% subtotal pancreatectomy with implantation ofhepatic tissue homogenate into marked areas of subcutaneous tissue .Results: During the first three weeks the animals of group II showed both high blood glucose andserum AFP levels, then gradually started to decline and became normal around the period of sixweeks and continued being normal till the end of experiment. The histological study showedregeneration and proliferation of small hepatic oval stem cells in the subcutaneous tissue around thesecond week and trans-differentiation of these cells into islet like cells and acinar like cells around thesixth week.Conclusions: Hepatic oval stem cell has multipotent character and can differentiate into new-lineagesand formation of different clonal cells, such as islet-like cells and acinar cells of the pancreas.

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