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Nucleolar organizer regions in giant cell lesions of the jaws in relation to clinico-pathological parameters

Author: Balkees T. Garib
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2009 Volume: 21 Issue: 4 Pages: 59-62
Publisher: Baghdad University جامعة بغداد

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Abstract

ABSTRACT
Background: It is to clarify the proliferatiove activity of the multinucleated giant cells and cellular component in giant
cell lesions of the jaw in correlation to their clinico-pathological features.
Materials and methods: This study was carried on 23 cases diagnosed as GC lesion of the jaw. Patient's personal and
clinical information were collected from their files. H&E and sliver nitrate stains were applied on their formalin fixed
paraffin embedded tissue sections.
Results: the mean AgNOR count in MGC/cell was 49.83 and NORs/nucleus was 5.8, and 74% of them were grouped
in large clusters and 26% were scattered. In PGCG the mean AgNOR count /MGC and /nucleus were significantly
lower than that of CGCL (38.2 vs 59.5 and 4.6 vs 6.8 respectively, P<0.04). The mean AgNOR count of spindle and
mononuclear cells were 4.7 in CGC lesions and 2.5 in peripheral lesions
Conclusion: evaluation of AgNORs showed that both MGC and fraction of mononuclear cells in CGCG were
significantly higher than that in PGCG. (J Bagh Coll Dentistry 2009; 21(4): 59-62).

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